{"id":9455,"date":"2014-09-02T14:29:37","date_gmt":"2014-09-02T18:29:37","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/busm-pathology\/?p=9455"},"modified":"2014-09-02T14:46:08","modified_gmt":"2014-09-02T18:46:08","slug":"august-2014-2","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/busm-pathology\/2014\/09\/02\/august-2014-2\/","title":{"rendered":"August 2014"},"content":{"rendered":"<p align=\"center\"><b><span style=\"text-decoration: underline;\">\u00a0<\/span><\/b><\/p>\n<h3><b><span style=\"text-decoration: underline;\">Pathology &amp; Laboratory Medicine News Items<\/span><\/b><\/h3>\n<p><strong>Announcements:<\/strong><\/p>\n<ul>\n<li>New Grant Funding in Pathology:<\/li>\n<\/ul>\n<p>The Department of Pathology and Laboratory Medicine had a 52% increase in grant funding for the<\/p>\n<p>period July 2013 to June 2014. This is an exceptional accomplishment on the part of our Department<\/p>\n<p>and it would be appropriate to share the specifics of these new grants.<\/p>\n<table border=\"1\" cellpadding=\"0\" cellspacing=\"0\">\n<tbody>\n<tr>\n<td valign=\"top\" width=\"108\">PI<\/td>\n<td valign=\"top\" width=\"564\">Alpaslan Dedeoglu<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Co-Investigator<\/td>\n<td valign=\"top\" width=\"564\"><b><span style=\"text-decoration: underline;\">Jan Krzysztof Blusztajn<\/span><\/b><\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Number<\/td>\n<td valign=\"top\" width=\"564\">1 I01 BX001875-01<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Title<\/td>\n<td valign=\"top\" width=\"564\">Cholinergic neurons and memory in GFP-AD mouse: a novel neurotrophic therapy<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Description<\/td>\n<td valign=\"top\" width=\"564\">The goal of these studies is to evaluate the efficacy of 7,8-dihydroxyflavone as a treatment of Alzheimer\u2019s disease in a mouse model.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table border=\"1\" cellpadding=\"0\" cellspacing=\"0\">\n<tbody>\n<tr>\n<td valign=\"top\" width=\"108\">PI<\/td>\n<td valign=\"top\" width=\"564\">Alpaslan Dedeoglu<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Co-Investigator<\/td>\n<td valign=\"top\" width=\"564\"><b><span style=\"text-decoration: underline;\">Jan Krzysztof Blusztajn<\/span><\/b><\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Number<\/td>\n<td valign=\"top\" width=\"564\">1 I01 BX002468-01<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Title<\/td>\n<td valign=\"top\" width=\"564\">Novel neurotrophic therapies in an optimized mouse model of GWVI<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Description<\/td>\n<td valign=\"top\" width=\"564\">The goal of these studies is to evaluate the efficacy of 7,8-dihydroxyflavone and exercise as a treatment of Gulf War Veterans\u2019 Illness in a mouse model.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table border=\"1\" cellpadding=\"0\" cellspacing=\"0\">\n<tbody>\n<tr>\n<td valign=\"top\" width=\"108\">PI<\/td>\n<td valign=\"top\" width=\"564\"><b><span style=\"text-decoration: underline;\">Jan Krzysztof Blusztajn<\/span><\/b><\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Co-Investigator<\/td>\n<td valign=\"top\" width=\"564\"><b><span style=\"text-decoration: underline;\">Tiffany Mellott, Barbara Slack, Ivana Delalle<\/span><\/b><\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Number<\/td>\n<td valign=\"top\" width=\"564\">R01 AG045031-01A1<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Title<\/td>\n<td valign=\"top\" width=\"564\">BMP9 as a juvenile protective factor in cognitive aging<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Description<\/td>\n<td valign=\"top\" width=\"564\">The goal of these studies is to determine the physiological functions of BMP9 and the potential of BMP9 as a trophic factor for aging brain and a therapeutic target in Alzheimer\u2019s disease.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table border=\"1\" cellpadding=\"0\" cellspacing=\"0\">\n<tbody>\n<tr>\n<td valign=\"top\" width=\"108\">PI<\/td>\n<td valign=\"top\" width=\"564\"><b><span style=\"text-decoration: underline;\">Shinichiro Kurosawa<\/span><\/b><\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Co-Investigator<\/td>\n<td valign=\"top\" width=\"564\"><b><span style=\"text-decoration: underline;\">D.J. Stearns-Kurosawa<\/span><\/b><\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Number<\/td>\n<td valign=\"top\" width=\"564\">R01 AI102931<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Title<\/td>\n<td valign=\"top\" width=\"564\">Development and Treatment of Pre-Clinical EHEC Models with HUS<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Description<\/td>\n<td valign=\"top\" width=\"564\">Hemolytic Uremic Syndrome (HUS) is a potentially lethal complication associated with enterohemorrhagic <i>E. coli<\/i> (EHEC) infection, mostly seen in children.\u00a0 There is no treatment available, other than supportive care.\u00a0 Using our (only) pre-clinical animal model of HUS, we will examine and optimize treatment with 1) passive immunity, using anti-Shiga toxin antibody, 2) a novel cell-permeable peptide-based therapeutic.\u00a0 The antibody will neutralize extracellular toxin, while the cell-permeable compound will neutralize toxin that is already intracellular.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table border=\"1\" cellpadding=\"0\" cellspacing=\"0\">\n<tbody>\n<tr>\n<td valign=\"top\" width=\"108\">PI<\/td>\n<td valign=\"top\" width=\"564\">Vipul Chitalia<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Co-investigator<\/td>\n<td valign=\"top\" width=\"564\"><b><span style=\"text-decoration: underline;\">Nader Rahimi<\/span><\/b><\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Number<\/td>\n<td valign=\"top\" width=\"564\">R01 CA175382<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Title<\/td>\n<td valign=\"top\" width=\"564\">Role of c-Cbl in Colon cancer<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Description<\/td>\n<td valign=\"top\" width=\"564\">The goal of these studies is to examine role of c-Cbl ubiquitin E3 ligase The goal of these studies is to examine role of c-Cbl ubiquitin E3 ligase<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table border=\"1\" cellpadding=\"0\" cellspacing=\"0\">\n<tbody>\n<tr>\n<td valign=\"top\" width=\"108\">PI<\/td>\n<td valign=\"top\" width=\"564\"><b><span style=\"text-decoration: underline;\">Daniel Remick<\/span><\/b><\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Co-Investigator<\/td>\n<td valign=\"top\" width=\"564\"><b><span style=\"text-decoration: underline;\">Nader Rahimi<\/span><\/b><\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Number<\/td>\n<td valign=\"top\" width=\"564\">R21 AI112887-01<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Title<\/td>\n<td valign=\"top\" width=\"564\">Mechanisms of phagocytic cell defects induced by inhibitory IgG<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Description<\/td>\n<td valign=\"top\" width=\"564\">We use an animal model of sepsis with 50% mortality over 28 days. We have been interested why half of the mice die when subjected to the same septic insult. Our preliminary work showed that antibodies present prior to the start of sepsis dictate if the mouse will live or die. It is not the antibody response to the septic challenge, it is the antibodies already present which determine survival. This grant will examine how these antibodies provide protection.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table border=\"1\" cellpadding=\"0\" cellspacing=\"0\">\n<tbody>\n<tr>\n<td valign=\"top\" width=\"108\">PI<\/td>\n<td valign=\"top\" width=\"564\"><b><span style=\"text-decoration: underline;\">Daniel Remick<\/span><\/b><\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Number<\/td>\n<td valign=\"top\" width=\"564\">R21 AA022122-01<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Title<\/td>\n<td valign=\"top\" width=\"564\">Alcohol Triggered Asthma: Mechanisms of Neuronal Control<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Description<\/td>\n<td valign=\"top\" width=\"564\">The major cause of asthma among inner city children are allergies to cockroach allergens. We have developed a murine model of asthma based on exposure to cockroach allergens. In the past few years there has been an increase in binge drinking among teenagers, as well as an increase in asthma. Our work shows that acute alcohol intoxication will trigger an asthma attack in mice that have been sensitized to cockroach allergens. This grant will study how the ethanol triggers the asthma attack.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table border=\"1\" cellpadding=\"0\" cellspacing=\"0\">\n<tbody>\n<tr>\n<td valign=\"top\" width=\"108\">PI<\/td>\n<td valign=\"top\" width=\"564\"><b><span style=\"text-decoration: underline;\">Susan Winandy<\/span><\/b><\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Number<\/td>\n<td valign=\"top\" width=\"564\">R21 CA176811-01<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Title<\/td>\n<td valign=\"top\" width=\"564\">Mechanism of Notch-induced leukemogenesis in lymphocytes<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"108\">Description<\/td>\n<td valign=\"top\" width=\"564\">Greater than 50% of T-acute lymphoblastic leukemia (T-ALL) display oncogenic activation of Notch. Understanding how Notch activation results in aggressive leukemia is of utmost importance to defining new targets for therapeutic intervention.\u00a0 This grant is aimed at defining novel nuclear and extranuclear roles for Notch in maintaining proliferation of leukemia cells.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"text-decoration: underline;\">\u00a0<\/span><b><span style=\"text-decoration: underline;\">Welcome to our New Graduate Students:<\/span><\/b><span style=\"text-decoration: underline;\"><\/span><\/p>\n<ul>\n<ul>\n<li><em><span style=\"text-decoration: underline;\">Stephanie Adams<\/span><span style=\"text-decoration: underline;\">, OD\/PhD<\/span><\/em><\/li>\n<li><em><span style=\"text-decoration: underline;\">Lois Bayigga, Masters<\/span><\/em><\/li>\n<li><em><span style=\"text-decoration: underline;\">Evan Catudal, Masters<\/span><\/em><\/li>\n<li><em><span style=\"text-decoration: underline;\">Junbo Chen, Masters<\/span><\/em><\/li>\n<li><em><span style=\"text-decoration: underline;\">Yuri Kim, PhD<\/span><\/em><\/li>\n<li><em><span style=\"text-decoration: underline;\">Asha Melo, Masters<\/span><\/em><\/li>\n<li><em><span style=\"text-decoration: underline;\">Tim Norman, PhD<\/span><\/em><\/li>\n<li><em><span style=\"text-decoration: underline;\">Ruoyu Tian, Masters<\/span><\/em><\/li>\n<li><em><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\">BJ Varian, Masters<\/span><\/span><\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><em>\u00a0<\/em><\/p>\n<ul>\n<li>From <b><span style=\"text-decoration: underline;\">Dr. David Sherr;<\/span><\/b> The Immunology Training Program (ITP) T32 Grant was renewed for 5 more years<\/li>\n<li><b><span style=\"text-decoration: underline;\">Dr. Ivana Delalle<\/span><\/b> will be presenting novel data at the XVIII International Congress of Neuropathology in Rio de Janeiro, Brazil, September 14-18, 2014: <b>Protein Expression of Alzheimer\u2019s disease- and Reduced Hippocampal Volume- Risk Genetic Loci in Human Hippocampus.<\/b> <i>Stephanie Adams<\/i><i><sup> 1<\/sup>, Tim Norman<sup>1<\/sup>, Kathy Tilton<sup>1<\/sup>, Sudha Seshadri<sup>2<\/sup>, and Ivana Delalle<sup>1<\/sup><\/i><\/li>\n<li><b><span style=\"text-decoration: underline;\">Daniel Remick, MD<\/span><\/b> was invited to discuss the creation of a physician scientist pathway at the American Board of Pathology Annual Retreat in Santa Fe, New Mexico in late July. The proposal would establish a board sanctioned physician scientist pathway in pathology, similar to pathways in other disciplines such as Internal Medicine and Pediatrics. The Association of Pathology Chairs has been advocating for this pathway for more than 10 years. The Trustees of the American Board of Pathology voted to approve the pathway.<\/li>\n<\/ul>\n<p><b><span style=\"text-decoration: underline;\">Publications: ACCEPTED<\/span>:<\/b><\/p>\n<ul>\n<li><b><span style=\"text-decoration: underline;\">Rahimi Nader<\/span><\/b> &amp; Catherine E Costello. Emerging Roles of Posttranslational Modifications in Signal Transduction and Angiogenesis. <i>PROTEOMICS, 2014<\/i><\/li>\n<li>Mathew H., Dittus C., <b><span style=\"text-decoration: underline;\">Malek A<\/span><\/b>., Negroiu A. \u201cBone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma.\u201d <i>Journal of Gastrointestinal Oncology; (accepted for publication August 2014)<\/i><\/li>\n<\/ul>\n<p><b><span style=\"text-decoration: underline;\">Publications: PUBLISHED<\/span>:<\/b><\/p>\n<ul>\n<li>Recent publication from <b><span style=\"text-decoration: underline;\">Panchenko Lab<\/span><\/b> (by <b><span style=\"text-decoration: underline;\">Siriwardana et al<\/span><\/b>, \u201cCell cycle-dependent chromatin shuttling of HBO1\u2013JADE1 histone acetyl transferase (HAT) complex\u201d\u00a0\u00a0<a href=\"https:\/\/www.landesbioscience.com\/journals\/cc\/article\/28759\/\">https:\/\/www.landesbioscience.com\/journals\/cc\/article\/28759\/<\/a>) has been featured in the <i>News &amp; Views section of the Journal<\/i>:<b> <\/b>\u201cHBO1:JADE1 at the cell cycle chromatin crossroads\u201d<b> <\/b>Comment on: Siriwardana NS, et al. Cell Cycle 2014; 13: 1885-1901; PMID: 24739512; by Brian R Calvi; Department of Biology; Indiana University; Bloomington, IN USA;\u00a0<a href=\"https:\/\/www.landesbioscience.com\/journals\/cc\/article\/29832\/\">https:\/\/www.landesbioscience.com\/journals\/cc\/article\/29832\/<\/a><b><i><span style=\"text-decoration: underline;\">\u00a0<\/span><\/i><\/b><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u00a0 Pathology &amp; Laboratory Medicine News Items Announcements: New Grant Funding in Pathology: The Department of Pathology and Laboratory Medicine had a 52% increase in grant funding for the period July 2013 to June 2014. This is an exceptional accomplishment on the part of our Department and it would be appropriate to share the specifics [&hellip;]<\/p>\n","protected":false},"author":938,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/posts\/9455"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/users\/938"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/comments?post=9455"}],"version-history":[{"count":20,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/posts\/9455\/revisions"}],"predecessor-version":[{"id":9480,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/posts\/9455\/revisions\/9480"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/media?parent=9455"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/categories?post=9455"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/tags?post=9455"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}