{"id":715,"date":"2009-01-07T17:12:39","date_gmt":"2009-01-07T21:12:39","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/busm-pathology\/?p=715"},"modified":"2009-01-08T11:25:46","modified_gmt":"2009-01-08T15:25:46","slug":"january-2009","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/busm-pathology\/2009\/01\/07\/january-2009\/","title":{"rendered":"January 2009"},"content":{"rendered":"<p class=\"MsoNormal\" style=\"text-align: left\"><strong><span style=\"text-decoration: underline\"><span style=\"font-size: 16pt\">Pathology &amp; Laboratory Medicine News Items <\/span><\/span><\/strong><\/p>\n<p class=\"MsoNormal\" style=\"text-align: left\"><strong><span style=\"text-decoration: underline\"><\/span><\/strong><strong><span style=\"text-decoration: underline\"><span style=\"font-size: 16pt;font-family: &quot;Comic Sans MS&amp;quot\">Happy New Year!<\/span><\/span><\/strong><\/p>\n<p class=\"MsoNormal\" style=\"text-align: left\"><strong><span style=\"text-decoration: underline\">Announcements:<\/span><\/strong><\/p>\n<p class=\"MsoNormal\">BU Bridge, the Boston University Clinical and Translational Science Institute, is delighted to announce the awardees of its 2008-2009 Pilot Project and Methods Project Grants and K12 Fellowship.<span> <\/span>These awardees were chosen after reviewing many outstanding applications.<span> <\/span>One of the PILOT PROJECT GRANTS was awarded to <span style=\"text-decoration: underline\">Nader Rahimi, PhD<\/span>: <strong>Identification of Novel Anti-Angiogenesis Agent for Treatment of Angiogenesis-associated Eye Diseases<\/strong>. The goal of this project is to study the efficacy and pharmacokinetics of PLC\u00e31 peptide inhibitor conjugated with two different carriers (PLCI-I and PLCI-II fusion octamer PLC\u00e31 peptides) in inhibiting choroidal neovascularization (CNV) in an animal model. Dr. Rahimi&#8217;s group has shown that PLCI-I and PLCI-II fusion octamer PLC\u00e31 peptides are cell membrane permeable and inhibit endothelial cell proliferation and angiogenesis in vitro.<span> <\/span><\/p>\n<p class=\"MsoNormal\"><span style=\"text-decoration: underline\">Dr. Kazem Azadzoi<\/span> has been appointed to the Surgery Scientific Merit Review board of the Department of Veterans Affairs (V A) Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development for a term ending 2012<strong><\/strong><\/p>\n<p class=\"MsoNormal\">Recent updates to the Pathology Resident Curriculum includes a Molecular Pathology rotation. The molecular pathology rotation includes exposure to testing performed in anatomic pathology and microbiology. In addition a\u00a06 lecture introductory series was created to provide background knowledge. Attendings: Nancy Miller and Karen Quillen; Faculty Member: Shi Yang; Residents: John Lee and Bethany Tierno, and technical support staff Beverly Orr, Audrey Quinn, and Charline Mack were involved in creating this new curriculum<span style=\"font-size: 10pt;font-family: Arial\">.<\/span><strong><\/strong><\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 36pt;text-indent: -18pt\"><strong><span style=\"text-decoration: underline\">Basic Life Support Certification<\/span><\/strong> Renewed for:<strong><\/strong><\/p>\n<ul>\n<li>\n<div class=\"MsoNormal\" style=\"margin-left: 54pt;text-indent: -18pt\">Dr. Steven Bogen<\/div>\n<\/li>\n<\/ul>\n<p class=\"MsoNormal\" style=\"margin-left: 36pt;text-indent: -18pt\"><strong><span style=\"text-decoration: underline\">Grants<\/span><\/strong><\/p>\n<ul>\n<li>\n<div class=\"MsoNormal\" style=\"margin-left: 54pt;text-indent: -18pt\">Grant awarded from the DoD PCRP for 3 years to Steve Bogen\u2019s group.<strong><span style=\"text-decoration: underline\"> <\/span><\/strong>The project is to study peripheral leukocytes in patients with elevated PSA levels.<strong><span style=\"text-decoration: underline\"> <\/span><\/strong>The goal is to identify an adjunct biomarker that could increase the specificity of the PSA test, thereby reducing the need for prostate biopsy<strong><\/strong><\/div>\n<\/li>\n<\/ul>\n<p class=\"MsoNormal\" style=\"margin-left: 36pt;text-indent: -18pt\"><strong><span style=\"text-decoration: underline\">Publications:<\/span><\/strong><\/p>\n<ul>\n<li>\n<div class=\"MsoNormal\" style=\"margin-left: 54pt;text-indent: -18pt\">Hyunjin Shin, Yue Zhang, <span style=\"text-decoration: underline\">Madhumita Jagannathan<\/span>, Hatice Hasturk, Alpdogan Kantarci, Honsgheng Liu, Thomas Van Dyke, Lisa Ganley-Leal, and <span style=\"text-decoration: underline\">Barbara Nikolajczyk<\/span>, <strong>&#8220;B cells from periodontal disease patients express surface Toll-like Receptor 4&#8221;<\/strong> in the\u00a0Journal of Leukocyte Biology. Accepted on Dec 5 2008.<br \/>\n<strong><\/strong><\/div>\n<\/li>\n<li>\n<div class=\"MsoNormal\" style=\"margin-left: 54pt;text-indent: -18pt\">Dr. Rosana Meyer&#8217;s manuscript entitled <strong>&#8220;Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1\/FLT-1 in leukemic cancer Cells&#8221;<\/strong> (Rosana D Meyer, Todd Golde and Nader Rahimi) is\u00a0accepted for publication in the Cancer Research Journal.\u00a0This is Dr. Meyer&#8217;s second paper accepted for publication\u00a0within less than two months.<br \/>\n<strong><\/strong><\/div>\n<\/li>\n<li>\n<div class=\"MsoNormal\" style=\"margin-left: 54pt;text-indent: -18pt\"><span style=\"font-size: 11pt;font-family: Arial\">Finnerty CC, Jeschke MG, Herndon DN, Gamelli R, Gibran N, Klein M, Silver G, Arnoldo B, <span style=\"text-decoration: underline\"><span>Remick D<\/span><\/span>, Tompkins RG: <strong>Temporal Cytokine Profiles In Severely Burned Patients: A Comparison Of Adults And Children<\/strong>, Mol Med 2008, <\/span>1076-1551<br \/>\n<strong><\/strong><\/div>\n<\/li>\n<li>\n<div class=\"MsoNormal\" style=\"margin-left: 54pt;text-indent: -18pt\">Sperry JL, Friese RS, Frankel HL, West MA, Cuschieri J, Moore EE, Harbrecht BG, Peitzman AB, Billiar TR, Maier RV, <span style=\"text-decoration: underline\"><span>Remick DG<\/span><\/span>, Minei JP: <strong>Male gender is associated with excessive IL-6 expression following severe injury<\/strong>, J Trauma 2008, 64:572-5<span style=\"font-size: 11pt;font-family: Arial\">78<br \/>\n<\/span><strong><\/strong><\/div>\n<\/li>\n<li>\n<div class=\"MsoNormal\" style=\"margin-left: 54pt;text-indent: -18pt\"><span style=\"text-decoration: underline\">Natarajan S, Kim J, <span>Remick DG<\/span><\/span>: <strong>Acute pulmonary lipopolysaccharide tolerance decreases TNF-alpha without reducing neutrophil recruitment<\/strong>. <em>J Immunol <\/em>2008, 181:8402-8408.<br \/>\n<strong><\/strong><\/div>\n<\/li>\n<li>\n<div class=\"MsoNormal\" style=\"margin-left: 54pt;text-indent: -18pt\">Minter RM, Bi X, Ben-Josef G, Wang T, Hu B, Arbabi S, Hemmila MR, Wang SC, <span style=\"text-decoration: underline\"><span>Remick DG<\/span><\/span>, Su GL: <strong>LPS-binding protein mediates LPS-induced liver injury and mortality in the setting of biliary obstruction<\/strong>. <em>Am J Physiol Gastrointest Liver Physiol <\/em>2009, 296:G45-54<br \/>\n<strong><\/strong><\/div>\n<\/li>\n<li>\n<div class=\"MsoNormal\" style=\"margin-left: 54pt;text-indent: -18pt\">Merritt, W., Y. G. Lin, L. Y. Han, A. A. Kamat, W. A. Spannuth, R.<span> <\/span>Schmandt, D. Urbauer, L. A. Pennacchio, J-F Cheng, A. Zeidan, H. Wang, P. Mueller, <span style=\"text-decoration: underline\">M.. E. Lenburg<\/span>, J. W. Gray, S. Mok, M. J. Birrer, G. Lopez- Berestein, R. L. Coleman, M. Bar-Eli, A. K. Sood.<span> <\/span>2008.<span> <\/span><strong>Decreased expression of RNA interference machinery, Dicer and Drosha, is associated with poor outcome in ovarian cancer patients<\/strong>.<span> <\/span>New England Journal of Medicine.<span> <\/span>359:2641-2650.<br \/>\n<strong><\/strong><\/div>\n<\/li>\n<li>\n<div class=\"MsoNormal\" style=\"margin-left: 54pt;text-indent: -18pt\"><span lang=\"ES-MX\">Schembri, F., S. Sridhar, C. Perdomo, A. Gustafson, X. Zhang, A.<span> <\/span><\/span>Ergun, J. Lu, G. Liu, X. Zhang, J. Bowers, K. Sensinger, J.J. Collins, J. Brody, R. Getts, <span style=\"text-decoration: underline\">M.E. Lenburg<\/span>, A. Spira.<span> <\/span><strong>MicroRNAs as modulators of smoking-induced gene-expression changes in human airway epithelium<\/strong>.<span> <\/span>Proceedings of the National Academy of Sciences.<span> <\/span>In Press.<br \/>\n<strong><\/strong><\/div>\n<\/li>\n<li>\n<div class=\"MsoNormal\" style=\"margin-left: 54pt;text-indent: -18pt\">Ibifiri Wilcox,1 Kevin Boettger,1 Lance Greene,1 Anita Malek,1 Lance Davis,1<strong><span style=\"text-decoration: underline\"> <\/span><\/strong>Martin H. Steinberg,2,3 Hong-Yuan Luo,1,2 and <span style=\"text-decoration: underline\">David H.K. Chui<\/span> <strong>Hemoglobin Kenya composed of a- and (Agb)-fusion-globin chains,<span style=\"text-decoration: underline\"> <\/span>associated with hereditary persistence of fetal hemoglobin.<\/strong> American Journal of Hematology <em><span lang=\"EN-GB\">84: 55-58, January 2009<br \/>\n<\/span><\/em><strong><\/strong><\/div>\n<\/li>\n<li>\n<div class=\"MsoNormal\" style=\"margin-left: 54pt;text-indent: -18pt\">Jozef Bartunek, MD, PHD,*,\u2020 Leen Delrue, PHD,*,\u2020 Frederik Van Durme, MD,*Olivier Muller, MD, PHD,* Filip Casselman, MD, PHD,\u2021 Bart De Wiest, RN,* Romaric Croes, MD,\u00a7<strong><span style=\"text-decoration: underline\"> <\/span><\/strong>Sofie Verstreken, MD,* Marc Goethals, MD,* Herbert de Raedt, MD,* Jaydeep Sarma, MD, PHD,<strong><span style=\"text-decoration: underline\"> <\/span><\/strong><span style=\"text-decoration: underline\">Lija Joseph, MD<\/span>,_ Marc Vanderheyden, MD,*,\u2020 Ellen O. Weinberg, PHD <strong>Nonmyocardial Production of ST2 Protein in Human<span style=\"text-decoration: underline\"> <\/span>Hypertrophy and Failure Is Related to Diastolic Load. <\/strong>Journal of the American College of Cardiology Vol. xx, No. x, 2008<strong><\/strong><\/div>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Pathology &amp; Laboratory Medicine News Items Happy New Year! Announcements: BU Bridge, the Boston University Clinical and Translational Science Institute, is delighted to announce the awardees of its 2008-2009 Pilot Project and Methods Project Grants and K12 Fellowship. These awardees were chosen after reviewing many outstanding applications. One of the PILOT PROJECT GRANTS was awarded [&hellip;]<\/p>\n","protected":false},"author":1131,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/posts\/715"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/users\/1131"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/comments?post=715"}],"version-history":[{"count":5,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/posts\/715\/revisions"}],"predecessor-version":[{"id":717,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/posts\/715\/revisions\/717"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/media?parent=715"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/categories?post=715"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/tags?post=715"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}