{"id":13727,"date":"2016-02-03T13:37:57","date_gmt":"2016-02-03T18:37:57","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/busm-pathology\/?p=13727"},"modified":"2016-02-03T13:37:57","modified_gmt":"2016-02-03T18:37:57","slug":"pathology-laboratory-medicine-news-items-december-2015-january-2016","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/busm-pathology\/2016\/02\/03\/pathology-laboratory-medicine-news-items-december-2015-january-2016\/","title":{"rendered":"Pathology &#038; Laboratory Medicine News Items December 2015 &#8211; January 2016"},"content":{"rendered":"<ul>\n<li><strong><span style=\"text-decoration: underline;\">Announcements:<\/span><\/strong>\n<ul>\n<li>Congratulations are in order to the following Department of Pathology members: BRAVO!\n<ul>\n<li><strong><span style=\"text-decoration: underline;\">Chris Andry, MPhil, PhD<\/span><\/strong>; for being appointed Chair of the Boston University Research and Clinical Connection Subcommittee until December 2017, BRAVO!<\/li>\n<li><strong><span style=\"text-decoration: underline;\">Abigail Brown, MFS, MLS (ASCP):<\/span><\/strong> for being appointed a Voting Member of the Boston University Research and Clinical Connection Subcommittee until December 2017, BRAVO!<\/li>\n<li><strong><span style=\"text-decoration: underline;\">Shinichiro Kurosawa, MD, PhD<\/span><\/strong>; for being appointed a Voting Member to the Boston University Laboratory Safety Committee Space \/ Infrastructure Subcommittee until December 2017, BRAVO!<\/li>\n<\/ul>\n<\/li>\n<li>On December 3, 2015 <strong><span style=\"text-decoration: underline;\">Daniel Remick, MD<\/span><\/strong> gave a talk <em>\u201cMild Traumatic Brain Injury Augments Host Defenses against Pathogens\u201d <\/em>at the Institute of Neuroscience and Physiology at Sahlgrenska Academy at the University of Gothenburg<\/li>\n<li><strong><span style=\"text-decoration: underline;\">Daniel Remick, MD<\/span><\/strong> was invited to serve as the opponent for Sara Svahn at the University of Gothenburg in Sweden on December 4, 2015. The title of Sara\u2019s thesis was <em>\u201cEffects of dietary fatty acids on the immune system\u201d. <\/em>Scandinavian countries have a tradition of bringing in an outside expert to ensure that the thesis work has sufficient rigor and depth. This outside member of the committee has the title of opponent. At the two hour defense, the opponent presents background information about the topic of the thesis, in this case sepsis. The student then presents for about 40 minutes, which is then followed by an hour of questioning by the opponent. Sara Syahn, PhD, successfully Defended<\/li>\n<li><strong><span style=\"text-decoration: underline;\">Chloe Habib<\/span><\/strong> and <strong><span style=\"text-decoration: underline;\">Leah Persky<\/span><\/strong>, both students in the Masters in Nutrition Program, joined the <strong><span style=\"text-decoration: underline;\">Nikolajczyk Lab<\/span><\/strong> as of January 2016<\/li>\n<li>The Residency Program had an <span style=\"text-decoration: underline;\">ACGME Site Visit<\/span> in January to review our program. The Department has been working diligently since last spring to increase the teaching curriculum for the residents. One of the issues identified through the survey in 2015 was lack of scholarly opportunities. The Department will be launching a series of paper writing workshops this spring and all the residents will be invited.<\/li>\n<li>The <span style=\"text-decoration: underline;\">College of American Pathologists (CAP)<\/span> performed their unannounced Site Visit on January 27, 2016. Seventeen inspectors from the Lifespan System in Rhode Island spent the day thoroughly reviewing both Anatomic Pathology and Laboratory Medicine. The lab inspection went very well with only a few deficiencies identified. This outstanding inspection result was due to the hard work by the pathology faculty and staff in the months leading up to the preparation. BRAVO<\/li>\n<\/ul>\n<\/li>\n<li><strong><span style=\"text-decoration: underline;\">PUBLICATIONS ACCEPTED<\/span><\/strong>:\n<ul>\n<li>Thurmond P, Yang JH and <strong><span style=\"text-decoration: underline;\">Azadzoi KM<\/span> <\/strong>entitled &#8220;LUTS in pelvic ischemia: A new concept in voiding dysfunction&#8221; &#8212; <em>Accepted for publication in\u00a0AJP \u2013 Renal Physiol<\/em><\/li>\n<li><strong><span style=\"text-decoration: underline;\">Ding Y<\/span><\/strong>, Francis J, Kalish J, <strong><span style=\"text-decoration: underline;\">Deshpande A<\/span><\/strong>, <strong><span style=\"text-decoration: underline;\">Quillen K<\/span><\/strong>. Recurrent focal segmental glomerulosclerosis resistant to plasma exchange, and improvement after surgical repair of arteriovenous fistula aneurysms. <em>Clinical Kidney Journal [in press]<\/em><\/li>\n<\/ul>\n<\/li>\n<li><strong><span style=\"text-decoration: underline;\">PUBLICATIONS PUBLISHED<\/span><\/strong>:\n<ul>\n<li>Zhifeng Huang, William M. Marsiglia, Upal Basu Roy, <strong><span style=\"text-decoration: underline;\">Nader Rahimi<\/span><\/strong>, Dariush Ilghari, Huiyan Wang, Huaibin Chen, Weiming Gai, Steven Blais, Thomas A. Neubert, Alka Mansukhani, Nathaniel J. Traaseth, Xiaokun Li, \u00a0Moosa Mohammadi. Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C\u03b3. <em>Molecular Cell, December 10, 2015. <a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1097276515009028\">http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1097276515009028<\/a><\/em><\/li>\n<li><strong><span style=\"text-decoration: underline;\">Lawreen Connors, PhD<\/span><\/strong> and Colleagues Publish Findings in <em>ATTRwt Amyloidosis Cohort<\/em><a href=\"http:\/\/www.bu.edu\/amyloid\/2016\/01\/22\/connors-and-colleagues-publish-findings-in-attrwt-amyloidosis-cohort\/\">http:\/\/www.bu.edu\/amyloid\/2016\/01\/22\/connors-and-colleagues-publish-findings-in-attrwt-amyloidosis-cohort\/<\/a>\n<ul>\n<li>Data on the largest cohort of ATTRwt amyloidosis patients yet reported (n=121), referred to our institution over a 20-year observational period, were recently reported in the prestigious heart journal, <em>Circulation<\/em>.\u00a0 The publication, entitled\u00a0\u201cHeart failure due to age-related cardiac amyloid disease associated with wild-type transthyretin:\u00a0 a prospective, observational cohort study,\u201d was authored by Dr. Lawreen H. Connors and colleagues from the Amyloidosis Center at Boston University. \u00a0These data establish the natural history of ATTRwt, provide statistical basis for the design of future\u00a0interventional clinical trials, and highlight the need for more sensitive diagnostic tests and disease-specific treatments for this disease. \u00a0For more information, see\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26660282\"><em>Circulation<\/em>, 133:282-290, 2016.<\/a><\/li>\n<\/ul>\n<\/li>\n<li>Ozturk S, Papageorgis P, Lambert AW, Wong CK, Thiagalingam A, Abdolmaleky HM, Cohen HT, and <strong><span style=\"text-decoration: underline;\">Thiagalingam S<\/span><\/strong>, 2016. SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. Proc. Natl. Acad. Sci. USA. 113(3): 638-643. <a href=\"https:\/\/urldefense.proofpoint.com\/v2\/url?u=http-3A__www.pnas.org_content_113_3_638.full.pdf-3Fwith-2Dds-3Dyes&amp;d=CwMFAg&amp;c=2rxEOw2KLbNB-I14iNYDhE3HM0YslhWt2FDmep0EPOI&amp;r=wXf9IMKUcD0GxK0qDtR-eMBPxD9t9uZWl7ma9NGVY7g&amp;m=fBIhHq86eq4VDZ2DCLZKhfrK_veBA6s_v0nPlT-9Hp0&amp;s=4VFlHxLsXtZodpbkkGETguEQ8tk-4anMYkHo1Q5_c8o&amp;e=\">http:\/\/www.pnas.org\/content\/113\/3\/638.full.pdf?with-ds=yes<\/a>\n<ul>\n<li>Metastatic dissemination of cancer cells represents a significant clinical obstacle to curative therapy and it is the major cause of death of patients affected by cancers. Despite the advent of advanced technologies, the discovery of new metastasis suppressor genes that prevent the spread of breast cancer to distal sites using genomic efforts has been slow potentially due to their primary mode of regulation by epigenetic mechanisms. The team led by Dr. Sam Thiagalingam reveals that the protein serum deprivation response (SDPR) is regulated by epigenetic rather than genetic mechanisms enabling the cancer cells to readily adapt to new microenvironments at distal sites away from the initial sites at which the cancer cells formed.\u00a0 Interestingly, analysis of gene expression data sets indicated a loss of SDPR in multiple tumor types including breast, bladder, colorectal, kidney, lung, pancreatic and ovarian cancers as well as in sarcomas. Follow up studies of this research may help with better prognosis and in the development of precision cancer therapies of metastatic cancer.<\/li>\n<li>Editor\u2019s choice: Science\u00a0 22 Jan 2016:Vol. 351, Issue 6271, pp. 351. <a href=\"https:\/\/urldefense.proofpoint.com\/v2\/url?u=http-3A__science.sciencemag.org_content_351_6271_twil&amp;d=CwMFAg&amp;c=2rxEOw2KLbNB-I14iNYDhE3HM0YslhWt2FDmep0EPOI&amp;r=wXf9IMKUcD0GxK0qDtR-eMBPxD9t9uZWl7ma9NGVY7g&amp;m=fBIhHq86eq4VDZ2DCLZKhfrK_veBA6s_v0nPlT-9Hp0&amp;s=SfJAyNAQErpUCUqI4zeYrZQggP21QRIppJuJrQsEoqY&amp;e=\">http:\/\/science.sciencemag.org\/content\/351\/6271\/twil<\/a><\/li>\n<li><a href=\"https:\/\/urldefense.proofpoint.com\/v2\/url?u=http-3A__www.bumc.bu.edu_busm_2016_01_08_epigenetic-2Dregulation-2Dof-2Dmetastatic-2Dbreast-2Dcancer-2Dprogression-2Dcould-2Dguide-2Dprognosis-2Dand-2Dfuture-2Dtherapies_&amp;d=CwMFAg&amp;c=2rxEOw2KLbNB-I14iNYDhE3HM0YslhWt2FDmep0EPOI&amp;r=wXf9IMKUcD0GxK0qDtR-eMBPxD9t9uZWl7ma9NGVY7g&amp;m=fBIhHq86eq4VDZ2DCLZKhfrK_veBA6s_v0nPlT-9Hp0&amp;s=9w-2lp0LE9X_khTf6nr-cLO-dKlQaG2CTmSVDO5ma8g&amp;e=\">http:\/\/www.bumc.bu.edu\/busm\/2016\/01\/08\/epigenetic-regulation-of-metastatic-breast-cancer-progression-could-guide-prognosis-and-future-therapies\/<\/a><\/li>\n<li><a href=\"https:\/\/urldefense.proofpoint.com\/v2\/url?u=http-3A__medicalxpress.com_news_2016-2D01-2Depigenetic-2Dmetastatic-2Dbreast-2Dcancer-2Dprognosis.html&amp;d=CwMFAg&amp;c=2rxEOw2KLbNB-I14iNYDhE3HM0YslhWt2FDmep0EPOI&amp;r=wXf9IMKUcD0GxK0qDtR-eMBPxD9t9uZWl7ma9NGVY7g&amp;m=fBIhHq86eq4VDZ2DCLZKhfrK_veBA6s_v0nPlT-9Hp0&amp;s=VH7ZxXiyKV2KK56AQnxlQd8Kv4tmcZd29RKTktd-A0U&amp;e=\">http:\/\/medicalxpress.com\/news\/2016-01-epigenetic-metastatic-breast-cancer-prognosis.html<\/a><\/li>\n<li><a href=\"https:\/\/urldefense.proofpoint.com\/v2\/url?u=http-3A__health-2Dinnovations.org_2016_01_11_major-2Depigenetic-2Dmetastasis-2Dsupressor-2Didentified-2Dfor-2Dbreast-2Dcancer_&amp;d=CwMFAg&amp;c=2rxEOw2KLbNB-I14iNYDhE3HM0YslhWt2FDmep0EPOI&amp;r=wXf9IMKUcD0GxK0qDtR-eMBPxD9t9uZWl7ma9NGVY7g&amp;m=fBIhHq86eq4VDZ2DCLZKhfrK_veBA6s_v0nPlT-9Hp0&amp;s=fhHUm6J1mtOG11NYdgMwHcMqyT_SHG2LPrAXuyUczms&amp;e=\">http:\/\/health-innovations.org\/2016\/01\/11\/major-epigenetic-metastasis-supressor-identified-for-breast-cancer\/<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Announcements: Congratulations are in order to the following Department of Pathology members: BRAVO! Chris Andry, MPhil, PhD; for being appointed Chair of the Boston University Research and Clinical Connection Subcommittee until December 2017, BRAVO! Abigail Brown, MFS, MLS (ASCP): for being appointed a Voting Member of the Boston University Research and Clinical Connection Subcommittee until [&hellip;]<\/p>\n","protected":false},"author":939,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/posts\/13727"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/users\/939"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/comments?post=13727"}],"version-history":[{"count":1,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/posts\/13727\/revisions"}],"predecessor-version":[{"id":13728,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/posts\/13727\/revisions\/13728"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/media?parent=13727"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/categories?post=13727"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/tags?post=13727"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}