{"id":13184,"date":"2015-09-24T09:33:18","date_gmt":"2015-09-24T13:33:18","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/busm-pathology\/?p=13184"},"modified":"2015-09-28T00:31:24","modified_gmt":"2015-09-28T04:31:24","slug":"departmental-seminar-friday-september-25","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/busm-pathology\/2015\/09\/24\/departmental-seminar-friday-september-25\/","title":{"rendered":"Departmental Seminar &#8211; Friday October 2"},"content":{"rendered":"<h2 style=\"text-align: left;\">October 2\u00a0\u2013 Friday @ 2:00<\/h2>\n<h2 style=\"text-align: center;\"><\/h2>\n<h2 style=\"text-align: center;\">\u201cHow Presenilin Mutations Cause Alzheimer\u2019s Disease\u201d<\/h2>\n<h3 style=\"text-align: center;\"><strong><b><span>Raymond Kelleher III, MD, Ph<\/span><\/b>D<\/strong><\/h3>\n<p style=\"text-align: center;\">Associate Professor of Neurology<br \/>\n<span>Principal Investigator, Center for Human Genetic Research<br \/>\n<\/span>Massachusetts General Hospital; Harvard Medical School<\/p>\n<p style=\"text-align: center;\">Refreshments at 1:45 p.m.<\/p>\n<h2 style=\"text-align: center;\"><span style=\"font-size: 13px;\">\u000b670 Albany Street \u2013 Lobby Level #107\/108<\/span><\/h2>\n<p>Contact:<\/p>\n<p>Program Director, Barbara Slack, PhD<br \/>\nProgram Coordinator: Debra Kiley, 414-7914<\/p>\n<p><strong>Target Audience: <\/strong>Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT\u2019s Bulletin).<\/p>\n<p><strong>At the conclusion of this activity participants will be able to<\/strong>: 1)\u00a0<span>) state that mutations in the Presenilin-1 (PSEN1) gene are the major cause of familial Alzheimer\u2019s disease (FAD); 2) report that Presenilins play essential roles in memory formation,\u00a0 \u00a0 \u00a0synaptic function, and neuronal survival and 3) recognize that how PSEN1 mutations cause\u00a0 FAD is unclear, and pathogenic\u00a0 mechanisms based on gain or loss of function have been proposed.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>October 2\u00a0\u2013 Friday @ 2:00 \u201cHow Presenilin Mutations Cause Alzheimer\u2019s Disease\u201d Raymond Kelleher III, MD, PhD Associate Professor of Neurology Principal Investigator, Center for Human Genetic Research Massachusetts General Hospital; Harvard Medical School Refreshments at 1:45 p.m. \u000b670 Albany Street \u2013 Lobby Level #107\/108 Contact: Program Director, Barbara Slack, PhD Program Coordinator: Debra Kiley, 414-7914 [&hellip;]<\/p>\n","protected":false},"author":9112,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[16418],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/posts\/13184"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/users\/9112"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/comments?post=13184"}],"version-history":[{"count":3,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/posts\/13184\/revisions"}],"predecessor-version":[{"id":13188,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/posts\/13184\/revisions\/13188"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/media?parent=13184"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/categories?post=13184"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/tags?post=13184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}