{"id":6507,"date":"2014-06-30T05:31:28","date_gmt":"2014-06-30T09:31:28","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/busm-pathology\/?page_id=6507"},"modified":"2022-08-24T11:16:25","modified_gmt":"2022-08-24T15:16:25","slug":"glomerular-hypertension-research","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/busm-pathology\/research\/glomerular-hypertension-research\/","title":{"rendered":"Glomerular Hypertension"},"content":{"rendered":"<p><script type=\"text\/javascript\">\/\/ <![CDATA[ function toggleOverlay(){ var overlay = document.getElementById('overlay'); var specialBox = document.getElementById('specialBox'); overlay.style.opacity = .8; if(overlay.style.display == \"block\"){ overlay.style.display = \"none\"; specialBox.style.display = \"none\"; } else { overlay.style.display = \"block\"; specialBox.style.display = \"block\"; } } \/\/ ]]><\/script><\/p>\n<p><!-- Start Overlay --><\/p>\n<div id=\"overlay\"><\/div>\n<p><!-- End Overlay --><br \/>\n<!-- Start Special Centered Box --><\/p>\n<div id=\"specialBox\">\n<p style=\"text-align: center;\"><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"\/\/www.youtube.com\/embed\/a0MjjFECzs0?rel=0;3;autohide=1;showinfo=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><br \/>\n<button onmousedown=\"toggleOverlay()\">Close Video<\/button><\/p>\n<\/div>\n<div id=\"test1\">\n<style><!-- div.img { margin: 5px; padding: 10px; border: 0px solid #FFFFFF; background:#CCCC99; height: 300px; width: 525px; float: left; text-align: center; box-shadow: 5px 5px 5px #888888;} div.img img { display: inline; margin: 5px; border: 5px solid #ffffcc; } div.img a:hover img {border: 1px solid #990000;} div.desc { text-align: left; font-weight: normal; width: 110px; margin: 5px; } --><\/style>\n<div class=\"img\"><a href=\"\/busm-pathology\/home\/people_main\/joel-m-henderson-md-phd\/\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" class=\"popup\" alt=\"Connors\" src=\"\/busm-pathology\/files\/2014\/07\/JHImage1.png\" height=\"225\" width=\"450\" \/><br \/>\n<\/a>Joel Henderson MD PhD<\/div>\n<\/div>\n<p><span style=\"color: white;\"><\/span><\/p>\n<p>&#8211;<\/p>\n<p>&#8211;<\/p>\n<p>&#8211;<\/p>\n<p>&#8211;<\/p>\n<p>&#8211;<\/p>\n<p>&#8211;<\/p>\n<p>&#8211;<\/p>\n<p>&#8211;<\/p>\n<p>&#8211;<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><button onmousedown=\"toggleOverlay()\"><a href=\"\/busm-pathology\/files\/2014\/08\/circle3.png\"><img loading=\"lazy\" src=\"\/busm-pathology\/files\/2014\/08\/circle4.png\" alt=\"play_button2\" width=\"50\" height=\"45\" class=\"aligncenter size-full wp-image-5205\" \/><\/a><\/button><\/p>\n<p>Systematic Hypertension is associated with changes in glomerular hemodynamics and progressive glomerular damage. As kidney damage progresses, glomerular perfusion pressure increases in remaining viable glomeruli, in order to drive compensatory hyperfiltration. This glomerular capillary hypertension is translated into increased mechanical stress affecting glomerular cells, including podocytes, mesangial, and endothelial cells. The <a href=\"\/busm-pathology\/home\/people_main\/joel-m-henderson-md-phd\/\">Henderson Lab<\/a> is studying how these mechanical forces can influence cell signaling and function, leading to glomerular cell injury and irreversible glomerular damage in the long term.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Close Video Joel Henderson MD PhD &#8211; &#8211; &#8211; &#8211; &#8211; &#8211; &#8211; &#8211; &#8211; &nbsp; Systematic Hypertension is associated with changes in glomerular hemodynamics and progressive glomerular damage. As kidney damage progresses, glomerular perfusion pressure increases in remaining viable glomeruli, in order to drive compensatory hyperfiltration. This glomerular capillary hypertension is translated into increased [&hellip;]<\/p>\n","protected":false},"author":1111,"featured_media":0,"parent":22,"menu_order":8,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/pages\/6507"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/users\/1111"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/comments?post=6507"}],"version-history":[{"count":44,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/pages\/6507\/revisions"}],"predecessor-version":[{"id":16344,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/pages\/6507\/revisions\/16344"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/pages\/22"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/media?parent=6507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}