{"id":61,"date":"2007-06-12T14:15:00","date_gmt":"2007-06-12T18:15:00","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/busm-pathology\/busm-faculty-profiles\/s-yang-md\/"},"modified":"2024-05-30T13:54:25","modified_gmt":"2024-05-30T17:54:25","slug":"s-yang-md","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/busm-pathology\/home\/people_main\/s-yang-md\/","title":{"rendered":"Shi Yang, MD, MSc."},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><a href=\"\/busm-pathology\/files\/2009\/04\/yang.jpg\"><img loading=\"lazy\" class=\"alignnone size-medium wp-image-1087\" src=\"\/busm-pathology\/files\/2009\/04\/yang.jpg\" alt=\"yang\" width=\"207\" height=\"192\" \/><\/a><\/p>\n<p>Clinical Professor<br \/>\nDepartment of Pathology and Laboratory Medicine<br \/>\nBoston University School of Medicine<br \/>\nDirector, Diagnostic Molecular Pathology Lab<br \/>\nDivision of Anatomic Pathology<br \/>\nBoston Medical Center<\/p>\n<h3>Degree(s):<\/h3>\n<p>MB (MD equivalent), Hebei Medical College, ShijiaZhuang, China. 1978-1983. Medicine<br \/>\nMSc, Chinese Academy of Medical Sciences, Beijing, China. 1983-1986. Etiology,<br \/>\nCarcinogenesis &amp; Experimental Cancer Pathology.<\/p>\n<h3>ACADEMIC APPOINTMENTS:<\/h3>\n<ul><\/ul>\n<ul>\n<li>1990-1992:\u00a0 Research Associate\n<ul>\n<li>Mallory Institute of Pathology, Boston University Medical Center, Boston MA.<\/li>\n<\/ul>\n<\/li>\n<li>1993-2011: \u00a0Assistant Professor\n<ul>\n<li>Department of Pathology and Laboratory Medicine Boston University School of Medicine, Boston MA.<\/li>\n<\/ul>\n<\/li>\n<li>2008 Assistant Professor and Faculty Member\n<ul>\n<li>Division of Graduate Medical Science Boston University Medical Campus, Boston MA<\/li>\n<\/ul>\n<\/li>\n<li>2011 Associate Professor\n<ul>\n<li>Department of Pathology and Laboratory Medicine Boston University School of Medicine, Boston MA<\/li>\n<\/ul>\n<\/li>\n<li>2011\u00a0 Research Faculty, Cytology Fellowship Program\n<ul>\n<li>Department of Anatomic Pathology, Boston Medical Center.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul><\/ul>\n<h3>MEMBERSHIP IN PROFESSIONAL SOCIETIES &amp; INTEREST GROUPS:<\/h3>\n<ul><\/ul>\n<ul>\n<li>10\/1991- American Society for Cell Biology (ASCB).<\/li>\n<li>03\/2008- Association for Molecular Pathology (AMP-ASIP)<\/li>\n<li>2009-\u00a0\u00a0\u00a0\u00a0\u00a0 Member, United States and Canadian Academy of Pathology (USCAP)<\/li>\n<li>1993-\u00a0\u00a0\u00a0\u00a0\u00a0 Member, Breast Cancer Research Program, BUSM<\/li>\n<li>2005-\u00a0\u00a0\u00a0\u00a0\u00a0 Member, Cancer Research Center, BUSM.<\/li>\n<li>2006-\u00a0\u00a0\u00a0\u00a0\u00a0 Member, Women\u2019s Health Interdisciplinary Research Center (WHIRC), BUMC.<\/li>\n<li>2008-\u00a0\u00a0\u00a0\u00a0\u00a0 Founding member, Genomic Science Institute (GSI), Boston University<\/li>\n<\/ul>\n<ul><\/ul>\n<h3>MAJOR RESEARCH INTERESTS:<\/h3>\n<ol>\n<li>In-vitro studies of genetic and epigenetic changes in colorectal polyps, on \u201cSerrated Polyp Neoplasia pathway\u201d.<\/li>\n<li>Breast cancer carcinogenesis and dietary prevention in animal models (green tea).<\/li>\n<li>Molecular diagnosis of hematology disorders, solid tumor and infectious diseases.<\/li>\n<li>Molecular pathways to melanoma.<\/li>\n<\/ol>\n<h3>RECENT PUBLICATIONS:<\/h3>\n<ol><\/ol>\n<ol>\n<li>MJ O&#8217;Brien, <strong>S Yang<\/strong>, JL Clebanoff, E Mulcahy, FA Farraye, M Amorosino, N Swan. Hyperplastic (serrated) Polyps of the Colorectal: Relationship of CpG &#8211; Island Methylation Phenotype and K-ras Mutation to Location and Histologic Subtype. AJSP 28(4): 423-434, 2004.<\/li>\n<li>Christopher S Huang, Michael J O&#8217;Brien, <strong>Shi Yang<\/strong> and Francis A Farraye. Hyperplastic polyps, Serrated Adenomas and the Serrated Neoplasia Pathway. Am J Gastroenterol. 99: 2242-2255, 2004.<strong> <\/strong><\/li>\n<li><strong>Shi Yang<\/strong>, Francis A. Farraye, Charline Mack, Oksana Posnik and Michael J. O&#8217;Brien. BRAF and KRAS Mutations in Hyperplastic Polyps and Serrated Adenomas of the Colorectum. AJSP 28(11): 1452-1459, 2004.<\/li>\n<li>Stephen A Murray, <strong>Shi Yang<\/strong>, Elizabeth Demicco, Haoqiang Ying, David H Sherr, Laurie J Hafer, Adrianne E Rogers, Gail Sonenshein and ZhiXiong Jim Xiao. Increased expression of MDM2, cyclin D1, and p27Kip1 in carcinogen-induced rat mammary tumors. J Cell Biochem. 2005 Aug.1;95(5):875-84.<\/li>\n<li>Michael J O\u2019Brien, <strong>Shi Yang<\/strong>,\u00a0 Charline Mack, Huihong Xu, Christopher S Huang, Elizabeth Mulcahy, Mark Amorosino, Francis A Farraye.\u00a0 Comparison of Microsatellite Instability, CpG Island Methylation Phenotype, BRAF and KRAS Status in Serrated Polyps and Traditional Adenomas Indicates Separate Pathways to Distinct Colorectal Carcinoma Endpoints. AJSP 30: 1491-1501, 2006<\/li>\n<li>Daniel W. Rosenberg, <strong>Shi Yang<\/strong>, Devon C. Pleau, Emily J. Greenspan, Richard G. Stevens, Thiruchandurai V. Rajan, Christopher D. Heinen, Joel Levine, Yijian Zhou, and Michael J. O&#8217;Brien.\u00a0 Mutations in <em>BRAF<\/em> and <em>KRAS<\/em> Differentially Distinguish Serrated versus Non-Serrated Hyperplastic Aberrant Crypt Foci in Humans.<strong> <\/strong>Cancer Res 2007; 67(8): 3551-3554.<\/li>\n<li>Karine Belguise, Shangqin Guo, <strong>Shi Yang<\/strong>, Adrianne E. Rogers, David C. Seldin, David H. Sherr, and Gail E. Sonenshein. Green Tea Polyphenols Reverse Cooperation between c-Rel and CK2 that Induces the Aryl Hydrocarbon Receptor, Slug, and an Invasive Phenotype. Cancer Res 2007;67(24):11742-50.<\/li>\n<li>Michael J O\u2019Brien, <strong>Shi Yang<\/strong>, Christopher S Huang, Courtney Shepherd, Sandra Cerda, Francis A Farraye. The Serrated Polyp Pathway to Colorectal Carcinoma. Diagnostic Histopathology. 2008;14(2):78-93.<\/li>\n<li>O.E. Dadzie, <strong>S. Yang, <\/strong>A. Emley, M. Keady, J. Bhawan and M. Mahalingam. RAS and RAF mutations in banal melanocytic aggregates contiguous with primary cutaneous melanoma: clues to melanomagenesis. BJD, 2009;160:368-375.<\/li>\n<li>Jeremy T. Hetzel, Christopher S. Huang, Jennifer A. Coukos, Kelsey Omstead, Sandra R. \u00a0Cerda, <strong><span style=\"text-decoration: underline;\">Shi Yang<\/span><\/strong>, Michael J. O\u2019Brien, Francis A. Farraye. <sup> <\/sup>Variation in the detection of serrated polyps in an average risk colorectal cancer screening cohort.\u00a0 <em>Am J Gastroenterol <\/em>2010;105:2656\u20132664.<\/li>\n<li>Andrew Emley, Lisa Nguyen, \u00a0<strong><span style=\"text-decoration: underline;\">Shi Yang<\/span><\/strong>, Meera Mahalingam. Somatic mutations in GNAQ in amelanotic\/hypomelanotic blue nevi. (Human Pathology 2010 Nov. 5, e-pub).<\/li>\n<li>Christopher S. Huang, Francis A. Farraye, <strong><span style=\"text-decoration: underline;\">Shi Yang<\/span><\/strong>, Michael J. O\u2019Brien. The Clinical \u00a0\u00a0Significance of Serrated Polyps. <em>Am J Gastroenterol <\/em>advance online publication, 2 November 2010; doi: 10.1038\/ajg.2010.429<\/li>\n<li>Brahmbhatt M, <strong><span style=\"text-decoration: underline;\">Yang S<\/span><\/strong>, Mahalingam M (2010). Proliferative Nodules in Congenital Nevi &#8211; A Histopathologic, Genetic and Immunohistochemical Reappraisal. J Clin Exp Dermatol Res 1:105. doi:10.4172\/2155-9554.1000105 (<a href=\"http:\/\/www.omicsonline.org\/2155-9554\/2155-9554-1-105.digital\/fscommand\/2155-9554-1-105.pdf\">http:\/\/www.omicsonline.org\/2155-9554\/2155-9554-1-105.digital\/fscommand\/2155-9554-1-105.pdf<\/a>).<\/li>\n<li>Elizabeth Park, <strong><span style=\"text-decoration: underline;\">Shi Yang<\/span><\/strong>, Andrew Emley, Kristen Decarlo, Joanna Richards and Meera Mahalingam. Lack of correlation between immunohistochemical expression of CKIT and KIT mutations in atypical acral nevi. (AJD-D-11-00065R1) Am J Derm. (Accept for publication; April 1, 2011).<strong><\/strong><\/li>\n<li><strong>Michael H. A. Roehrl, Marier Hernandez, <span style=\"text-decoration: underline;\">Shi Yang<\/span>, <\/strong><strong>Thomas G. Christensen<\/strong><strong>,<\/strong> Claudio Morera, and Julia Y. Wang \u201cHelicobacter Heilmannii Gastritis in a Young Patient with Pets\u201d Gastrointestinal Endoscopy (2011, in press)<\/li>\n<li>Feller K, <strong><span style=\"text-decoration: underline;\">Yang S<\/span><\/strong>, Tung N, Lee JE, Mahalingam M. c-myc in Kaposi\u2019s sarcoma \u2013 Incidental or causative. Abstract # 491(poster session March 20 AM) USCAP 2012 Annual Meeting, March 17-23, 2012, Vancouver, BC, Canada.<\/li>\n<li>Miller DD, Emley A, <strong><span style=\"text-decoration: underline;\">Yang S<\/span><\/strong>, Richards JE, Lee JE, Deng A, Hoang MP, Mahalingam M. Mixed versus pure variants of desmoplastic melanoma: a genetic and immunohistochemical appraisal. Mod Pathol. 2011 Dec 9. doi: 10.1038\/modpathol.2011.196. [Epub ahead of print] PMID: 22157936.<\/li>\n<li>Michael J O&#8217;Brien, Robert D Odze, Sandra Cerda, Huihong Xu, Katherine Downey, Bohdana Burke, Christopher S Huang, Francis A Farraye, <strong><span style=\"text-decoration: underline;\">Shi Yang<\/span><\/strong>. \u00a0Ectopic Crypt Formation and Other Histological Parameters in Relation to BRAF and KRAS Mutation Status of Dysplastic Serrated and Non-Serrated Colorectal Polyps. \u00a0USCAP 2012 Annual Meeting Abstract#717, Tuesday AM 3\/20\/12, Vancouver \u00a0BC, Canada.<\/li>\n<\/ol>\n<ol><\/ol>\n<h3>CURRENT FOUNDING:<\/h3>\n<ol>\n<li>NIH\/NIEHS: PO1 ES 11624-05 (PI, G. Sonenshein); Signaling Pathways in Stages of Mammary Tumorigenesis. Dr. Yang is a Co-Investigator in the Animal Bio-model Core.<\/li>\n<li>ACS seed grant through Cancer center in BUSM- Human papillomavirus Vaccination in Boston University Medical Center Patients (Dr. Yang is a member of this study in charge if molecular tests).<\/li>\n<\/ol>\n<h3>CONTACT INFO:<\/h3>\n<p style=\"padding-left: 30px;\">E-mail, <a href=\"mailto:shiyang@bu.edu\">shiyang@bu.edu<\/a>; shi.yang@BMC.org<br \/>\nTel: \u00a0\u00a0617-414-5057<br \/>\nLab: \u00a0617-414-7916<br \/>\nFax: \u00a0\u00a0617-414-5315<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Clinical Professor Department of Pathology and Laboratory Medicine Boston University School of Medicine Director, Diagnostic Molecular Pathology Lab Division of Anatomic Pathology Boston Medical Center Degree(s): MB (MD equivalent), Hebei Medical College, ShijiaZhuang, China. 1978-1983. Medicine MSc, Chinese Academy of Medical Sciences, Beijing, China. 1983-1986. Etiology, Carcinogenesis &amp; Experimental Cancer Pathology. ACADEMIC APPOINTMENTS: 1990-1992:\u00a0 [&hellip;]<\/p>\n","protected":false},"author":1131,"featured_media":0,"parent":3281,"menu_order":51,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/pages\/61"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/users\/1131"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/comments?post=61"}],"version-history":[{"count":10,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/pages\/61\/revisions"}],"predecessor-version":[{"id":16947,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/pages\/61\/revisions\/16947"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/pages\/3281"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/media?parent=61"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}