{"id":48,"date":"2007-04-27T10:16:33","date_gmt":"2007-04-27T14:16:33","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/busm-pathology\/busm-faculty-profiles\/m-obrien-md-mph\/"},"modified":"2019-06-07T14:44:19","modified_gmt":"2019-06-07T18:44:19","slug":"m-obrien-md-mph","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/busm-pathology\/home\/people_main\/m-obrien-md-mph\/","title":{"rendered":"Michael J O&#8217;Brien, MD, MPH"},"content":{"rendered":"<p><img loading=\"lazy\" src=\"https:\/\/www.bumc.bu.edu\/busm-pathology\/files\/Images\/portraits\/mob.jpg\" alt=\"\" width=\"134\" height=\"144\" \/><\/p>\n<h3><strong>Academic Title &#8211;<\/strong> Emeritus Professor<\/h3>\n<h3><strong>Education &#8211;<\/strong><\/h3>\n<ul>\n<li>1971 M.B., B.ch. (MD Equivalent), National University of Ireland , Galway .<\/li>\n<li>1992 M.P.H. (Quantitative Methods), Harvard University , School of Public Health<\/li>\n<\/ul>\n<h3><strong>\u00a0<\/strong><strong>Professional Qualifications and Diplomas &#8211;<\/strong><\/h3>\n<ul>\n<li>Membership of the Royal College of Pathologists, ( UK ), 1977<\/li>\n<li>American Board of Pathology, Certification in Anatomic Pathology, 1984<\/li>\n<li>American Board of Pathology, Special Competency in Cytopathology, 1994<\/li>\n<\/ul>\n<h3><strong>\u00a0<\/strong><strong>Major Administrative Responsibilities:<\/strong><\/h3>\n<ul>\n<li>1996 &#8211; \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Chief, Department of Anatomic Pathology, Boston Medical Center<\/li>\n<li>2003 \u2013 06 \u00a0 \u00a0 \u00a0Chairman, ad interim, Dept. of Pathology and Lab Medicine, BUSM<\/li>\n<li>1991 \u2013 03 \u00a0 \u00a0 \u00a0 Vice-chairman for Anatomic Pathology, Department of Pathology and Laboratory Medicine, Boston University School of Medicine (BUSM), Boston, MA<\/li>\n<\/ul>\n<h3><strong>Academic Appointments:<\/strong><\/h3>\n<ul>\n<li>1994-present\u00a0\u00a0 Professor of Public Health (Epidemiology and Biostatistics), BUSPH<\/li>\n<li>1988-present\u00a0\u00a0 Professor of Pathology and Laboratory Medicine, BUSM<\/li>\n<li>1986-87\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Lecturer on Pathology, University College, Dublin, Ireland<\/li>\n<li>1982-86 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Associate Professor of Pathology, Boston University School of Medicine<\/li>\n<li>1980-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Faculty Member, Division of Graduate Medical &amp; Dental Sciences, BU<\/li>\n<li>1980-84\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Lecturer on Medicine, Harvard Medical School<\/li>\n<li>1978-82 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Assistant Professor of Pathology, BUSM<\/li>\n<li>1976-78\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Teaching Fellow, BUSM<strong>\u00a0<\/strong><\/li>\n<\/ul>\n<h3><strong>Hospital Appointments:<\/strong><\/h3>\n<ul>\n<li>1996 \u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0 Chief of Anatomic Pathology, Boston Medical Center<\/li>\n<li>1991-1996\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Chief, Department of Anatomic Pathology, The University Hospital and Boston \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 City Hospital<strong>\u00a0<\/strong><\/li>\n<\/ul>\n<h3><strong>Professional Societies, Honors and\u00a0 Committees:<\/strong><\/h3>\n<ul>\n<li>1989-2012. Fellow of the Royal College of Pathologists (UK)<\/li>\n<li>1981-91\u00a0\u00a0\u00a0\u00a0\u00a0 Consultant Pathologist, National Polyp Study<\/li>\n<li>1988-98\u00a0\u00a0\u00a0\u00a0\u00a0 Advisory Board, World Health Organization Collaborating Center for Prevention of Colorectal Cancer<\/li>\n<li>1992\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Consultant to Committee on Practice Guidelines, Management of Colon Polyps, American College of Gastroenterology<\/li>\n<li>1992 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Committee on Guidelines for colorectal cancer screening and surveillance, WHO.<\/li>\n<li>1992-\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Editorial Board, American Journal of Surgical Pathology<\/li>\n<li>1997\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Chairman, Task Force on Digital Imaging, International Academy of Cytology<\/li>\n<li>2001- 06 \u00a0\u00a0\u00a0 Member, Surgical Pathology Committee, College of American Pathologists<\/li>\n<li>2003 &#8211; \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Fellow, American College of Gastroenterology<\/li>\n<li>2004\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Member, US National Taskforce on Colon Cancer<\/li>\n<li>2006-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Fellow, Faculty of Pathology (Hon), Royal College of Physicians of Ireland<\/li>\n<li>2006 -11\u00a0\u00a0\u00a0\u00a0 Consultant, Cancer Research Ireland, Irish Cancer Society<\/li>\n<li>2008\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Member, International Validation Panel, Irish National Cancer Screening Service.<\/li>\n<li>2009 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 President, New England Society of Pathologists.<\/li>\n<li>2009\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Medtronic Distinguished Alumnus Award, National University of Ireland, Galway.<\/li>\n<li>2010\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Committee on Real Time Histological Methods in Clinical Practice. ASGE.<\/li>\n<li>2010\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 NIH Consensus Conference, Exploring Serrated Polyps of the Colon, Cleveland Clinic.<\/li>\n<\/ul>\n<p><strong>Research<\/strong>: Colorectal cancer and precursors: epidemiology, prevention, biomarkers &amp; molecular pathology.<strong>\u00a0<\/strong><\/p>\n<p><a href=\"https:\/\/scholar.google.com\/citations?user=89U1_hgAAAAJ&amp;hl=en\">Google Scholar Profile link<\/a><strong>\u00a0<\/strong><\/p>\n<h3><strong>Selected Publications <\/strong>(from a total of ~160)<strong>\u00a0<\/strong><\/h3>\n<ol>\n<li><span style=\"text-decoration: underline;\">O&#8217;Brien MJ<\/span>, Winawer SJ, Gottlieb LS, Sternberg S, Zauber A, Diaz B, Dickersin GR, Ewing S, Geller S, Kasimian D, Komorowski R, Szporn A\u00a0 and the National Polyp Study Workgroup.\u00a0 The National Polyp Study: Determinants of High Grade Dysplasia in Colorectal Adenomas.\u00a0\u00a0 Gastroenterology, 98:371-379, 1990. PMID: 2403953<\/li>\n<li>Winawer S J, Zauber A J, Ho M N, <span style=\"text-decoration: underline;\">O\u2019Brien, M J<\/span>, Gottlieb L S et al. Prevention of Colorectal Cancer by Colonoscopic Polypectomy. NEJM, 329:1977-81, 1993. PMID: 8247072<\/li>\n<li><span style=\"text-decoration: underline;\">O&#8217;Brien MJ<\/span>, Yang S, Clebanoff JL, Mulcahy E, Farraye FA, Amorosino M, Swan N.Hyperplastic (Serrated) Polyps of the Colorectum: Relationship of CpG- Island Methylator Phenotype and K-ras Mutation to Location and Histologic Subtype. Am J Surg Pathol, 2004, 28:423-434. PMID: 15087661<\/li>\n<li><span style=\"text-decoration: underline;\">O\u2019Brien MJ<\/span>, Winawer SJ, Zauber AG, Bushey MT, Sternberg SS, Gottlieb LS, Bond JH, Waye JD, Schapiro M for the National Polyp Study Workgroup. Flat Adenomas in the National Polyp Study (NPS): is there an increased risk of high grade dysplasia initially or during surveillance? Clin Gastro Hepatol 2004 2(10): 905-911. PMID: 15476154<\/li>\n<li><span style=\"text-decoration: underline;\">O\u2019Brien MJ<\/span>, Yang S, Mack C, Xu H, Huang CS, Mulcahy E, Amorosino M,<sup> <\/sup>Farraye F. Comparison of Microsatellite Instability, CpG-Island Methylation Phenotype, BRAF and KRAS Status in Serrated Polyps and Traditional Adenomas Indicates Separate Pathways to Distinct Colorectal Carcinoma Endpoints. Am J Surg Pathol 2006;30:1491-1501. PMID: 17122504<\/li>\n<li>Rosenberg DW, Yang S, Pleau DC, Greenspan EJ, Stevens RG, Rajan TV, Heinen CD, Levine J, Zhou Y, <span style=\"text-decoration: underline;\">O&#8217;Brien MJ<\/span>. Mutations in BRAF and KRAS Differentially Distinguish Serrated versus Non-Serrated Hyperplastic Aberrant Crypt Foci in Humans. Cancer Res. 2007,67(8):3551-4. PMID: 17440063<\/li>\n<li>Hetzel JT, Huang CS, Coukos JA, Omstead K, Cerda SR, Yang S, <span style=\"text-decoration: underline;\">O&#8217;Brien MJ<\/span>, Farraye FA. Variation in the Detection of Serrated Polyps in an Average Risk Colorectal Cancer Screening Cohort. Am J Gastroenterol. 2010 Dec;105(12):2656-64 PMID: 20717107<\/li>\n<li>Zauber AG, Winawer SJ,\u00a0<span style=\"text-decoration: underline;\">O&#8217;Brien MJ<\/span>, et al. Colonoscopic Polypectomy and Longterm Prevention of Colorectal Cancer Deaths. <span>N Engl J Med<\/span>.<span><\/span>2012<span>\u00a0<\/span>Feb 23;366(8):687-96. PMID: 22356322<\/li>\n<li>Qazi TM, <span style=\"text-decoration: underline;\">O&#8217;Brien MJ<\/span>, Farraye FA, Gould RW, Chen CA, Schroy PC 3rd. Epidemiology of goblet cell and microvesicular hyperplastic polyps. Am J Gastroenterol. 2014 Dec;109(12):1922-32.PMID: 25350766.<\/li>\n<li><span style=\"text-decoration: underline;\">MJ O&#8217;Brien<\/span>, Q Zhao, S Yang. Colorectal serrated pathway cancers and precursors.\u00a0Histopathology 66 (1), 49-65, 2015. PMID: 25263173<\/li>\n<\/ol>\n<ul><\/ul>\n<h3>Contact Information<\/h3>\n<ul>\n<li>Email \u2013 carasdad@bu.edu<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Academic Title &#8211; Emeritus Professor Education &#8211; 1971 M.B., B.ch. (MD Equivalent), National University of Ireland , Galway . 1992 M.P.H. (Quantitative Methods), Harvard University , School of Public Health \u00a0Professional Qualifications and Diplomas &#8211; Membership of the Royal College of Pathologists, ( UK ), 1977 American Board of Pathology, Certification in Anatomic Pathology, 1984 [&hellip;]<\/p>\n","protected":false},"author":1131,"featured_media":0,"parent":3281,"menu_order":33,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/pages\/48"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/users\/1131"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/comments?post=48"}],"version-history":[{"count":9,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/pages\/48\/revisions"}],"predecessor-version":[{"id":15585,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/pages\/48\/revisions\/15585"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/pages\/3281"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/busm-pathology\/wp-json\/wp\/v2\/media?parent=48"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}