{"id":25,"date":"2008-08-11T11:47:30","date_gmt":"2008-08-11T15:47:30","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/busm-pathology\/busm-faculty-profiles\/k-azadzoi-md-ma\/"},"modified":"2017-04-26T11:21:36","modified_gmt":"2017-04-26T15:21:36","slug":"k-azadzoi-md-ma","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/busm-pathology\/home\/people_main\/k-azadzoi-md-ma\/","title":{"rendered":"Kazem Azadzoi, M.D, M.A."},"content":{"rendered":"

\"www.image-size.com\"<\/a><\/p>\n

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Current Positions:<\/span><\/strong>
\nProfessor of Pathology (Boston University Medical School)
\nProfessor of Urology (Boston University Medical School)
\nDirector of Urology Research (Boston University & VA Boston)
\nSenior Health Scientist (VA Boston Healthcare System)<\/p>\n

Contact information:<\/span><\/strong>
\nBuilding 1A, Room 317
\n150 S. Huntington Ave
\nBoston, MA 01230
\nPhone: (857)-364-5602
\nFax: (857)-364-4540
\nEmail: kazadzoi@bu.edu<\/a><\/p>\n

Membership in Professional Organizations <\/span><\/strong>
\nAmerican Urological Association (AUA), 1991\u2013present
\nInternational Continence Society (ICS), 1995\u2013present
\nSociety of Urodynamics and Female Urology (SUFU), 2010\u2013present
\nInternational Society for Sexual Medicine (ISSM), 1992\u2013present
\nSexual Medicine Society of North America (SMS), 2015\u2013present
\nOxygen Club of California, 2011\u2013present
\nNorth-East Smooth Muscle Society, 2000\u2013present
\nSociety of Basic Urology Research (SBUR), 2005\u20132008
\nNational Bladder Foundation (NBF), 1999\u2013 2005<\/p>\n

Awards and Honors<\/span><\/strong>
\nJean-Francois Ginesti\u00e9<\/em> Prize<\/em><\/strong> for best research in Erectile Dysfunction, 1990.
\nEndourological Society Prize<\/em> <\/strong>for best research in Endourology, 1993.
\nJean-Francois Ginesti\u00e9<\/em> Prize<\/em><\/strong> for best research in Female Sexual Health, 1996.
\nJack Lapides<\/em> Prize<\/em> <\/strong>for best research in Neurourology, 1988.
\nAmerican Urological Association CIRCON<\/em> Prize<\/em> <\/strong>for best research in Prostate Disorders, 2000.
\nHall of Fame, <\/em><\/strong>Appointed to the International Continence Society Hall of Fame in 2005.
\nNational Register\u2019s Who\u2019s who in Executives and Professionals,<\/em><\/strong> included since 2005.
\nVIP, global Who\u2019s Who,<\/em><\/strong> included since 2007.
\nWho\u2019s Who in America, <\/em><\/strong>included since 2008.
\nThe Journal of Urology Best reviewer<\/em> Award<\/em><\/strong>, AUA 2012.
\nCertificate of Appreciation, <\/em><\/strong>Merit Review Program – VA Central Office, 2012.
\nThe Journal of Urology Best reviewer Award<\/em><\/strong>, AUA 2014.<\/p>\n

Editor and Editorial Boards<\/span><\/strong>
\nSection Editor, <\/em><\/strong>Oxidants and Antioxidants, 2012 – present
\nSection Editor,<\/em><\/strong> Journal of Biochemical and Pharmacological Research, 2012-present
\nSection Editor, <\/em><\/strong>BioMed Research International, 2013-present
\nEditorial Board<\/em><\/strong>, British Journal of Urology, \u201cInvestigative Urology\u201d, 2004-present
\nEditorial Board, <\/em><\/strong>World J. Clinical Urology (WJCU), 2011-present
\nEditorial Board, <\/em><\/strong>Austin Journal of Urology, <\/strong>2014-present
\nEditorial Board, <\/em><\/strong>SM Urology, <\/em><\/strong>2015\u2013present
\nEditorial Board,<\/em><\/strong> Int. J. Gynecol. Obst. Res, 2013-present
\nEditorial Board, <\/em><\/strong>The Scientific World Journal (TSWJ), 2011-present
\nEditorial Board, <\/em><\/strong>Open Access Journal of Urology, 2008-present
\nEditorial Board, <\/em><\/strong>Open Access Journal of Andrology, 2008-present
\nEditorial Board, <\/em><\/strong>Scientifica, 2012-present<\/p>\n

Institutional Committees & Peer Review Boards <\/span><\/strong>
\nChairman<\/em><\/strong>, VA Boston Health Care System IACUC, 06-08
\nChair Elect<\/em><\/strong>, VA Boston Health Care System IACUC, 2005
\nMember <\/em><\/strong>of Boston University Faculty Council, 2013-present
\nMember <\/em><\/strong>of Boston University Council, 2013-present
\nReview board member, <\/em><\/strong>VA Surgery Study Section, 08-11
\nReview board member,<\/em><\/strong> VA Middleton & Barnwell Awards for clinical & basic research, 2012
\nReview board member<\/em><\/strong>, NIH, NIDDK, Diabetes, Digestive, Kidney and Urology, 2014
\nReview board member<\/em><\/strong>, NIH, NIDDK, Diabetes, Digestive, Kidney and Urology, 2015
\nMember <\/em><\/strong>of VA Boston Healthcare System Steering Committee, 06-08
\nMember<\/em><\/strong> of Chief of Urology Search Committee, VA Boston Healthcare System, 2012
\nAd hoc reviewer<\/em><\/strong>, NIH, Clinical Sciences Special Emphasis Panel, Urology Section, 1999
\nAd hoc reviewer<\/em><\/strong>, NIH, Surgery, Anesthesiology and Trauma (SAT) study section, 1995
\nMember<\/em><\/strong> of Boston University Promotion Committee, 2007
\nMember <\/em><\/strong>of Boston University faculty network for studies of sexual dysfunction, 2008-present
\nMember<\/em><\/strong> of Boston University Promotion Committee, 2005<\/p>\n

Journals Reviewer<\/span><\/strong>
\nAmerican Journal of Urology, 1990-present
\nInternational J. of Impotence Research.<\/em> 1990-present
\nAmerican Journal of Physiology, 1997-present
\nUrology (The Gold Journal), 1992-present
\nJournal of Neurourology and Urodynamic, 1992-present
\nJournal of Andrology, 03-present
\nEuropean Urology, 03-present
\nAsian J. of Andrology, 03-present
\nMolecular and Cellular Biochemistry, 07-present
\nJournal of Sexual Medicine, 07-present
\nEuropean Surgical Research, 08-present
\nEuropean Journal of Obstetrics & Gynecology 2010-present
\nOxidants and Antioxidants in Medicine, 2011-present<\/p>\n

Research Areas<\/span><\/strong><\/p>\n

Dr. Azadzoi and colleagues were one of the earliest to introduce the concept of pelvic ischemia in the pathophysiology of lower urinary tract symptoms (LUTS) and erectile dysfunction (ED). Dr. Azadzoi is the developer of unique experimental model systems for studies of ischemia-associated LUTS and ED. His published work introduced a new concept suggesting that pelvic ischemia may be an independent factor in simultaneous development of LUTS and ED in the elderly patients. This concept received worldwide attention and led to multi-center clinical trials concerning pelvic ischemia and the incidence of LUTS and ED in the aging population.<\/p>\n

In clinical studies, Dr. Azadzoi and colleagues documented decreased bladder and prostate blood flow with aging and reported a close correlation between pelvic ischemia and the development of LUTS and ED in the male patients. His follow up studies with cell culture and experimental models revealed cellular and subcellular mechanisms underlying ischemic injury in the bladder, prostate and penile erectile tissues. In another clinical study, a close correlation between nocturia and sleep disordered breathing was documented. Follow up studies with oxycycler models showed that conditions simulating sleep apnea contributes to nocturia via mechanisms involving bladder oxidative stress and detrusor instability. These observations suggested that LUTS, ED and nocturia may be indicators of impending cardiovascular, respiratory and sleep disorders that should be further investigated.<\/p>\n

In basic research, Dr. Azadzoi and colleagues documented a number of signaling pathways and molecular mechanisms in lower urinary tract ischemia including RNA modifications, DNA damage, cell survival signaling, and altered protein expression. These changes in conjunction with lipid peroxidation and protein oxidation activated downstream pathways involving growth factors such as HIF, TGF-beta, VEGF and NGF and led to microvasculature damage, neurodegeneration, receptor modifications and fibrosis. Cultured cells exhibited differential reactions to hypoxia and oxidative stress conditions. Cellular reactions to hypoxia were associated with thickened deformed cell membrane, swollen mitochondria and enlarged endoplasmic reticulum (ER). Cellular reactions to oxidative stress were associated with partial loss of cell membrane, increased caveolae, swollen mitochondria with degraded cristae, splintered ER, and increased lysosomes. Reactions to hypoxia were consistent with activation of survival signaling, possibly to cope with lack of oxygen and energy demand. Changes in oxidative stress involved extensive cell damage and deterioration of the subcellular elements, suggesting a degenerative process. Mitochondria, ER and lysosomes mediated cultured cells reactions to disturbed oxygen tension. Cumulatively, these observations suggest leading roles of interrupted blood flow and disturbed oxygen tension in aging-associated LUTS and ED.\u00a0 Further research into the role of pelvic ischemia in LUTS-associated ED may lead to more effective diagnosis and better management of these problems.<\/p>\n

Dr. Azadzoi collaborates with other researchers in the national and international organizations. His research laboratories provide a conductive environment for productive research, teaching, training, scientific communication and collaboration.<\/p>\n

Research Team:<\/span><\/strong>
\nKazem Azadzoi, M.D., M.A. (Director)
\nJinghua Yang, Ph.D. (Investigator)
\nKimberly Leite-Morris, Ph.D. (Investigator)
\nMike Siroky, M.D. (Investigator)
\nLori Lerner, M.D. (Collaborator)
\nSubbaroa Yalla, M.D. (Collaborator)
\nMaryrose Sullivan, Ph.D. (Collaborator)
\nVivian Cristofaro, Ph.D. (Collaborator)
\nAbdulmaged Traish, Ph.D. (Consultant)
\nHan-Pil Choi (Collaborator)
\nYedan Li (Research Assistant)<\/p>\n

Positions available:<\/span><\/strong><\/p>\n

Doctoral and master degree candidates and post-doctoral fellows are welcomed to apply for training positions. We are seeking research associates and research assistants to join our investigators at the VA Boston Healthcare System research laboratories. Applicants should email their CVs to Dr. Azadzoi (kazadzoi@bu.edu<\/a>).<\/p>\n

Selected Publications:<\/span><\/strong><\/p>\n

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