Walther M. Pfeifer, MD
Adjunct Assistant Professor
Pathology & Laboratory Medicine
Boston University School of Medicine
Lab Director, East Side Clinical Laboratory
Sonic Healthcare
East Providence, RI
Education/Training –
1994 – 1995 | Internal Medicine, Medizinische Poliklinik, University of Wuerzburg, Germany |
1996 – 1997 | Anatomic Pathology, Medizinische Hochschule Hannover, Germany |
1997 – 1999 | Research Fellow, Experimental Pathology, Beth Israel Hospital, Boston, MA |
1999 – 2001 | Anatomic Pathology, University of Wuerzburg, Germany |
2002 – 2005 | Residency in Anatomic and Clinical Pathology, Beth Israel Deaconess Medical Center, Boston, MA |
2006 – 2006 | Clinical Fellow in Pediatric Pathology, Children’s Hospital, Boston, MA |
2006 – 2007 | Clinical Fellow in Hematopathology, Beth Israel Deaconess Medical Center, Boston, MA |
Board Certifications –
Anatomic and Clinical Pathology, 2007
Hematopathology, 2008
American Board of Pathology
Membership in Professional Societies –
- 2003 United States and Canadian Academy of Pathology
- 2003 American Society of Clinical Pathologists
- 2004 College of American Pathologists
- 2007 Massachusetts Medical Society
Research Interests –
- Hematopathology
- Vascular Pathology
Recent Publications –
- Pfeifer W, Levi E, Petrogiannis-Haliotis T, Lehmann L, Wang Z, Kadin ME. A murine xenograft model for human CD30+ anaplastic large cell lymphoma – successful growth inhibition with an anti-CD30 antibody (HeFi-1). Am J Pathol 1999; 155(4):1353-9.
- Schiemann WP, Pfeifer WM, Levi E, Kadin ME, Lodish HF. A deletion in the gene for transforming growth factor beta in a cutaneous T-cell lymphoma. Blood 1999; 15;94(8):2854-61.
- Levi E, Wang Z, Petrogiannis-Haliotis T, Pfeifer WM, Kempf W, Drews R, Kadin ME. Distinct effects of CD30 and Fas signalling in cutaneous anaplastic lymphomas: a possible mechanism for disease progression. J Invest Dermatol 2000; 115(6):1034-40.
- Mueller-Hermelink HK, Zettl A, Pfeifer W, Ott G. Pathology of lymphoma progression. Histopathology 2001; 38(4):285-306.
- Griesser H, Rauschert C, Pfeifer W, Monir H, Renner TJ, Embaye U, Neumann M. Different cell reactions upon stimulation of similar surface receptors: CD30 signaling in neoplastic T cell lines. Verh Dtsch Ges Zyt 2001; 22:114-122.
- Levi E, Pfeifer WM, Kadin ME. CD30-activation-mediated growth inhibition of anaplastic large-cell lymphoma cell lines: apoptosis or cell cycle arrest? Blood (letter) 2001; 98(5).
- Kempf W, Levi E, Kamarashev J, Kutzner H, Pfeifer W, Petrogiannis-Haliotis T, Burg G, Kadin ME. Fascin expression in CD30-positive cutaneous lymphoproliferative disorders. J Cutan Pathol 2002 May;29(5):295-300.
- Schiemann WP, Rotzer D, Pfeifer WM, Levi E, Rai KR, Knaus P, Kadin ME. Transforming growth factor-beta (TGF-beta)-resistant B cells from chronic lymphocytic leukemia patients contain recurrent mutations in the signal sequence of the type I TGF-beta receptor. Cancer Detect Prev 2004;28(1):57-64.
- Horn T, Kremer M, Dechow T, Pfeifer WM, Geist B, Perker M, Duyster J, Quintilla-Martinez L, Fend F. Detection of the activating JAK2 V617F mutation in paraffin-embedded trephine bone marrow biopsies of patients with chronic myeloproliferative diseases. J Mol Diagn. 2006 July;8(3):299-304.
- Maithel SK, Pratt W, Kelleher T, Avigan D, Goldman H, Pfeifer W, Pihan GA. Autoimmune pancreatitis in the setting of Castleman’s disease. Pancreas 2007 Nov:(35(4):384-7.
- Kremer M, Horn T, Koch I, Dechow T, Gattenloehner S, Pfeifer W, Quintanilla-Martinez L, Fend F. Qantitation of the JAK2V617F mutation in microdissected bone marrow trephines: equal mutational load in myeloid lineages and rare involvement of lymphoid cells. Am J Surg Pathol 2008 Jun;32(6):928-35.
Selected Abstracts –
- Pfeifer W, Levi E, Petrogiannis-Haliotis T, Zhenxi W, Kadin ME. Cytokine expression of CD30+ anaplastic large cell lymphoma cell lines – comparison of nodal versus cutaneous ALCL. United States and Canadian Academy of Pathology, San Francisco, 1999. Poster presentation.
- Pfeifer W, Levi E, Petrogiannis-Haliotis T, Zhenxi W, Kadin ME. Ki 1+ anaplastic large cell lymphoma expressing the t(2;5) translocation in triple immuno-deficient (SCID BEIGE) mice. German Society of Pathology, Jena, 1999. Platform presentation.
- Pfeifer W, Monir M, Neumann M, Berberich H, Griesser H. CD30 mutations and abnormal signal transduction in Hodgkin`s disease (HD)- and large cell anaplastic lymphoma (LCAL)-related cell lines. European Association of Hematopathology, London, 2000. Poster presentation.
- Pfeifer W, Vogel P, Griesser H. Analysis of cytokeratin 20 as a potential marker of malignancy. German Society of Pathology, Kiel, 2000. Platform presentation.
- Pfeifer W, Bryan B, Avigan D, Pihan G. Osteosclerotic/ myelofibrotic chronic myelogenous leukemia (CML) at presentation: A rare and possibly unique subset of CML. International Academy of Pathology, Athens, 2008, Poster presentation.
- Pfeifer W, Vakil H, Kurrer M, Levi E. Phosphorylation Status of retinoblastoma protein predicts survival in rituxan-treated follicular lymphomas. International Academy of Pathology, Athens, 2008, Poster presentation.