Department of Pathology & Laboratory Medicine: New News SUMMER 2021

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August 6th, 2021

Department of Pathology & Laboratory Medicine: New News SUMMER 2021

Announcements

  • Tiffany Mellott, PhD has been appointed as the Nancy L.R. Bucher, MD Assistant Professor in the Department of Pathology & Laboratory Medicine at BUSM. 
    • Dr Mellott served as a Research Assistant Professor in the Department of Pathology and Laboratory Medicine at Boston University School of Medicine (BUSM) since 2010 and was recently promoted to Assistant Professor.  Dr Mellott completed her PhD at BUSM in Dr Krzysztof Blusztajn’s laboratory in 2005 and has maintained her research program and active scholarly collaborations with our neuroscience group since then
    • Dr Mellott is an active research scientist with expertise in neuroscience and the mechanisms and role of dietary choline in cognitive enhancement and disease prevention. Dr Mellott has also contributed significantly to the department and BUSM, with a strong record of research, scholarship, “good citizenship”, mentorship and as an educational leader. We are fortunate to have Dr Mellott in the department and I anticipate that she will continue to advance her academic career at BUSM
    • The professorship is named for Dr. Nancy Bucher, a long time faculty member in our department, who made significant scientific contributions to the understanding of liver regeneration and the cholesterol synthesis pathway.  Dr Bucher was a ground-breaking, female, physician-scientist. Dr Bucher was a fellow of the American Association for the Advancement of Science as well as the American Academy of Arts and Sciences and has received the Distinguished Scientific Achievement Award from the American Liver Foundation. She was named as a significant contributor to her field in two Nobel Prize awardee speeches
  • Yachana Kataria, PhD, DABCC gave the Annual Stanley L. Robbins Lecture to the New England Society of Pathologists on January 26, 2021. Her talk was “Seroprevalence of SARS-CoV-2 IgG Antibodies and Risk Factors in Health Care Workers at Boston Medical Center”
  • Daniel Remick, M.D., has been appointed as the Editor-in-Chief for the scientific journal Shock®Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches. Dr. Remick is a Professor of Pathology & Laboratory Medicine at Boston University School of Medicine and former Department Chair. SHOCK® publishes papers detailing novel therapeutic approaches including immunomodulation, gene therapy, nutrition, and others. The journal’s mission fosters and promotes multidisciplinary studies that critically examine the etiology, mechanisms and novel therapeutics of shock-related pathophysiology. The journal excels as a vehicle for timely publication in the areas of basic and clinical studies of shock, trauma, sepsis, inflammation, ischemia, and related states. Papers in Shock® emphasize biologic mechanisms that determine the response to injury since this information ultimately facilitates improved care of the traumatized or septic individual
    • Shock® is The Official Journal of the Shock Society, the European Shock Society, the Indonesian Shock Society, the International Federation of Shock Societies, and the Official and International Journal of the Japan Shock Society.
  • CONGRATULATIONS!! We want to celebrate the recognition of our very own Microbiology Labas the Recipient of a BMC 2021 Be Exceptional Award! There was a virtual celebration on Wednesday, June 23 from 12-1 hosted by BMC President Kate Walsh and SVP Lisa Kelly-Croswell. Many went on and supported their fellow laboratorians who could not have done it without the support from the entire Clinical Lab and AP team.  I am so very proud of everyone!  We made it through COVID-19 (so far!). Congratulations, Bev Orr
    • From BMC Communications: This past year was a truly exceptional year, as our personal and professional lives were upended by the pandemic. While the year brought out the best in everyone at BMC, on June 23 we will be celebrating a special group of 31 colleagues who were chosen as truly exceptional by their peers
    • The winners were nominated by employees and providers, who were invited to submit nominations for individuals and teams who demonstrate exceptional performance in the areas of core valuesand priority goals. This year, a record-breaking 248 individual and team nominations were submitted – a testament to what an exceptional year it was and to the incredible admiration and respect BMC colleagues have for each other. A hospital-wide selection committee then chose the final 2021 Be Exceptional Award recipients based on their extraordinary performance, initiative, and teamwork.
    • Congratulations to all our 2021 Be Exceptional Award winners!
  • Nick Crossland was the recipient of a CTSI pilot award for the proposal entitled “Multimodal Microscopic Characterization of Novel Humanized Mouse Models of COVID-19″. In collaboration with fellow BUSM faculty members including Drs. Douam, Emili, and Connor and external collaborator Dr. Ploss (Princeton), this project will provide unprecedented insights into the cellular and molecular mechanisms that define SARS-CoV-2 immunopathogenesis and severe COVID-19 disease. Importantly, findings will be integrated with transcriptomics and proteomics datasets to elucidate specific biological pathways driving morphomolecular outcomes of disease and aims to identify novel therapeutic pathways to prevent or ameliorate outcomes of severe COVID-19
  • Several Resident Awards were given at the Residency Program Graduation on June 11th:
    •  Ilyas Yambayev, MD won this year 2021 Robert Foley MBA Award, The Academic Excellence Award at graduation ceremony on Friday, June 11, 2021.
      • Yambayev also received the Early Career Award for his abstract submission for the IASLC 2021
    •  Michael Kritselis, DO won the 2021 Vernon S. Truell Autopsy Award
    •  Lubna Suaiti M.B. B.Ch. – 2021 Leo Goodman Photomicrography Award
    •  Lina Ma, M.D. – 2021 Leo Goodman Gross Photography Award
  • Lina Ma will have a poster presentation at ASC’s 69th Annual Scientific Meeting being held in Las Vegas, November 11-14, 2021.  Lina Ma, MD, and Sandra Cerda, MDEvaluation of Malignant Cytologic Parameters to Distinguish Hürthle Cell Carcinoma (HCC) from Hürthle Cell Adenoma (HCA) in Thyroid Fine Needle Aspirate (FNA) with Hürthle Cell Lesion (HCL)
  • BUSM Faculty Promotions to Associate Professor
    •  Thor Stein, Pathology & Laboratory Medicine, is a neuropathologist who focuses on understanding the role of age, trauma and genetics on the development of multiple types of neurodegenerative disease. He is associate director of the Neuropathology Core for BU Alzheimer’s Disease & CTE Center and a site PI and neuropathologist for a number of brain biorepositories.
  • Ilyas Yambayev’s was accepted at IASLC 2021 WCLC and he received an Early Career Award for his work: Novel Low Malignant Potential/Vascular Invasive (LMPVI) Grade is Superior to WHO 2015 and IASLC 2020 Adenocarcinoma Grade; Ilyas Yambayev1, M.D., Travis B. Sullivan2, M.S., Kei Suzuki3, M.D., Virginia R. Litle3, M.D. Elliot L. Servais4, M.D., Cameron T. Stock4, M.D., Syed M. Quadri4, M.D., Kimberly M. Rieger-Christ2, Ph.D., Eric J. Burks1, M.D.
  • Eric Burks is on another abstract which was accepted for an oral presentation at the New England Section American Urological Association 90th Annual Meeting, Burlington, VT on Oct. 14, 2021: Urine miRNA Biomarkers that are Differentially Expressed in Lichen Sclerosus Induced and Non-Lichen Sclerosus Induced Urethral Stricture Disease
    • Additional presentations by Eric Burks:
    • 26, 2021 Fatal Consequences of COVID-19: Case studies from the Boston Medical Center autopsy experience
    • * SARS-CoV-2 Associated Hemophagocytic Lymphohistiocytosis: Charitha Vadlamudi, MD & Eric J. Burks, MD
    • * SARS-CoV-2 Associated Coagulopahty: Sanket Choksi, MD & Eric J. Burks, MD
    • * SARS-CoV-2 Post-Viral Pulmonary Inflammatory Reactions: Eric J. Burks, MD
      New England Society of Pathologists, Case Presentations, Boston, MA
    • 22, 2021 Pleomorphic Mantle Cell Lymphoma; New England Lymphoma Rounds, Boston, MA
    • 23, 2021 Immunopathology of SARS-CoV-2 Associated Diffuse Alveolar Damage: A case-control autopsy study using multiplex immunohistochemistry; Inaugural Mallory Alumni Rounds, Boston, USA & Dublin, Ireland
    • 13, 2021 Pulmonary Adenocarcinoma of Low Malignant Potential: An indolent lesion of epithelial origin? Early Detection Research Network Lung Collaborative Group, National Cancer Institute/National Institutes of Health
  • Burks also is a co-investigator on a BU CTSI grant that was funded:
    Highly Multiplexed Immunophenotyping of Aggressive Histologic Patterns of Early-Stage Lung Adenocarcinomas https://www.bumc.bu.edu/compbiomed/2021/06/15/cbm-faculty-members-awarded-ctsi-2021-integrated-pilot-grants/
  • Dennis Jones is lead and co-corresponding author on a study published in Nature Biomedical Engineering; https://www.nature.com/articles/s41551-021-00766-1
    • Zixiong (Mervin) Wang, an incoming Master’s student in the department, is 2ndauthor; https://www.nature.com/articles/s41551-021-00766-1
  • Jones was selected for the NIH Early Career Reviewer Program and will participate in the Tumor Progression and Metastasis study section in October
  • Nick Crossland gave a talk on Thursday, July 22nd at the ASV Conference Viral Pathogenesis Segment entitled “Fatal neuroinvasion of SARS-CoV-2 in K18-hACE2 mice is partially independent on hACE2 expression”
  • Pathology PhD Candidate, Razie Amraei, successfully completed her Qualifying Exams! Razie is completing her thesis work in Dr.Richard Wainford’s Lab
  • Welcome New Residents!!
    •  Dr. Isa Jacoba
    •  Soo Hyun Lee
    •  Ramya Narasimhan
    •  Adeyemi Sofoluwe
  • Welcome Incoming PhD/Masters Graduate Students:
    •  Samantha Calderazzo – MD/PhD
    •  Samantha Boyd – Masters Candidate
    •  Frankie Cervone-Maffa – Masters Candidate
      •  Farimah Ghorbani – Masters Candidate
      •  Tyler Lebner – Masters Candidate
      •  Yunqi Lu – Masters Candidate
      •  Kavya Menon – Masters Candidate
      •  Thea Nalan – Masters Candidate
      •  Melissa Pesta – Masters Candidate
      •  Egbe Tambe-Sangaya – Masters Candidate
      •  Wongel Zerihan – Masters Candidate
      •  Zixiong “Mervin” Wang – Masters Candidate

 

 

 

 

 

 

Publications Accepted:

Publications Published:

  • Brosnan-Cashman JA, Davis CM, Diplas BH, Meeker AK, Rodriguez FJ, Heaphy CM.; SMARCAL1 loss and alternative lengthening of telomeres (ALT) are enriched in giant cell glioblastoma. Modern Pathology. 2021 Jun 8. doi: 10.1038/s41379-021-00841-7.
  • Kang HJ, Oh JH, Kim YW, Kim W, An J, Sung CO, Kim J, Shim JH, Hwang S, Yu E, Heaphy CM*, Hong SM*. *Co-senior authors; Clinicopathological and molecular characterization of chromophobe hepatocellular carcinoma. Liver International. 2021 May 25. doi: 10.1111/liv.14975
  • Barker KA, Etesami NS, Shenoy AT, Arafa EI, Lyon de Ana C, Smith NM, Martin IM, Goltry WN, Barron AM, Browning JL, Kathuria H, Belkina AC, Guillon A, Zhong X, Crossland NA, Jones MR, Quinton LJ, Mizgerd JPLung-resident memory B cells protect against bacterial pneumonia. J Clin Invest. 2021 Jun 1;131(11). doi: 10.1172/JCI141810. PubMed PMID: 34060477; PubMed Central PMCID: PMC8159694
  • Kritselis M, Yambayev I, Prilutskiy A, Shevtsov A, Vadlamudi C, Zheng H, Elsadwai M, Ma L, Aniskovich E, Kataria Y, Higgins S, Sarita-Reyes C, Zuo T, Zhao Q, Quillen KBurks EJ.; Distinctive Pseudopalisaded Histiocytic Hyperplasia Characterizes the Transition of Exudative to Proliferative Phase of Diffuse Alveolar Damage in Patients Dying of COVID-19. Hum Pathol 2021 Jul 14;S0046-8177(21)00122-2. doi:10.1016/j.humpath.2021.06.008
  • Dennis JonesZixiong WangIvy X. ChenSue ZhangRohin BanerjiPin-Ji LeiHengbo ZhouVictoria XiaoCecilia KwongJan Willem M. van WijnbergenEthel R. PereiraBenjamin J. VakocPeigen HuangHadi T. NiaTimothy P. Padera: Solid stress impairs lymphocyte infiltration into lymph-node metastases: Nature Biomedical Engineering (2021)
  • Nick Crossland, et al; SARS-CoV-2 disrupts proximal elements in the JAK-STAT pathway. J Virol. PMID: 34260266
  • Sham Nambulli, Yufei Xiang, Natasha L Tilston-Lunel, Linda J Rennick, Zhe Sang, William B Klimstra, Douglas S Reed, Nicholas A Crossland, Yi Shi, W Paul Duprex. Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses. Sci Adv. 2021. PMID: 34039613
  • Kimberly A Barker, Neelou S Etesami, Anukul T Shenoy, Emad I Arafa, Carolina Lydon de Ana, Nichole Ms Smith, Ian Mc Martin, Wesley N Goltry, Alexander Ms Barron, Jeffrey L Browning, Hasmeena Kathuria, Anna C Belkina, Antoine Guillon, Xuemei Zhong, Nicholas A Crossland, Matthew R Jones, Lee J Quinton, Joseph P Mizgerd. Lung-resident memory B cells protect against bacterial pneumonia. J Clin Invest. 2021. PMID: 34060477
  • Zaroug Jaleel, Elizabeth Blasberg, Chelsea Troiano, Paige Montanaro, Sarah Mazzilli, Hans P Gertje, Nicholas A Crossland, Michael Platt, Jeffrey Spiegel. Association of Vaping with Decreased Vascular Endothelial Growth Factor Expression and Decreased Microvessel Density in Cutaneous Wound Healing Tissue in Rats. Wound Repair and Regen. PMID: 34129265
  • Da-Yuan Chen, Nazimuddin Khan, Brianna J Close, Raghuveera K Goel, Benjamin Blum, Alexander H Tavares, Devin Kenney, Hasahn L Conway, Jourdan K Ewoldt, Vipul C Chitalia,Nicholas A Crossland, Christopher S Chen, Darrell N Kotton, Susan C Baker, Serge Y Fuchs, John H Connor, Florian Douam, Andrew Emili, Mohsan Saeed SARS-CoV-2 disrupts proximal elements in the JAK-STAT pathway. J Vir.  2021. PMID: 34260266
  • Yuen RR, Steiner D, Pihl RMF, Chavez E, Olson A, Smith EL, Baird LA, Korkmaz F, Urick P, Sagar M, Berrigan JL, Gummuluru S, Corley RB, Quillen KBelkina AC, Mostoslavsky G, Rifkin IR, Kataria Y, Cappione AJ 3rd, Gao W, Lin NH, Bhadelia N, Snyder-Cappione JE. Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 viaMulti-Parameter Detection. Front Immunol. 2021;12:614676. doi: 10.3389/fimmu.2021.614676. eCollection 2021. PubMed PMID: 33897682; PubMed Central PMCID: PMC8062931