Area of Interest Molecular Interaction Networks, Precision Mass Spectrometry, Proteomics, Systems Biology
Charting the molecular networks of cells and tissues
My laboratory develops and applies advanced proteomic, molecular genetic, genomic and bioinformatic technologies to investigate the molecular associations and biological roles of the many varied macromolecules present in different cells, tissues and organisms. Our research team has outstanding skills in state-of-the-art protein mass spectrometry and other high-throughput techniques for investigating molecular interaction networks in a global systems-wide manner. Our group aims to generate comprehensive maps of the physical and functional “interactomes” of informative models, ranging from unicellular microbes like yeast or the bacterium E. coli to more complex metazoans such as worm, mouse and (increasingly) human. We expect these maps will lead to breakthrough mechanistic understanding of how cells and tissues function at a fundamental molecular level, and serve as valuable resources for the broader research community. Ultimately, our team aims to translate this basic knowledge into novel diagnostic and therapeutic tools, with an emphasis on cancer, cardiovascular disease and neurodegenerative disorders.
Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2021 Jan 07; 81(1):212.PMID:33417854
Paul I, White C, Turcinovic I, Emili A. Imaging the future: the emerging era of single-cell spatial proteomics. FEBS J. 2020 Dec 22. PMID:33351222
Basu A, Ash PE, Wolozin B, Emili A. Protein Interaction Network Biology in Neuroscience. Proteomics. 2020 Dec 14; e1900311. PMID: 33314619
Lee ES, Wolf EJ, Ihn SSJ, Smith HW, Emili A, Palazzo AF. TPR is required for the efficient nuclear export of mRNAs and lncRNAs from short and intron-poor genes. Nucleic Acids Res. 2020 11 18; 48(20):11645-11663. PMID:33091126
Pourhaghighi R, Ash PEA, Phanse S, Goebels F, Hu LZM, Chen S, Zhang Y, Wierbowski SD, Boudeau S, Moutaoufik MT, Malty RH, Malolepsza E, Tsafou K, Nathan A, Cromar G, Guo H, Al Abdullatif A, Apicco DJ, Becker LA, Gitler AD, Pulst SM, Youssef A, Hekman R, Havugimana PC, White CA, Blum BC, Ratti A, Bryant CD, Parkinson J, Lage K, Babu M, Yu H, Bader GD, Wolozin B, Emili A. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Cell Syst. 2020 Aug 26; 11(2):208. PMID:32853540
Kuzmanov U, Wang EY, Vanderlaan R, Kim DH, Lee SH, Hadipour-Lakmehsari S, Guo H, Zhao Y, McFadden M, Sharma P, Billia F, Radisic M, Gramolini A, Emili A. Mapping signalling perturbations in myocardial fibrosis via the integrative phosphoproteomic profiling of tissue from diverse sources. Nat Biomed Eng. 2020 09; 4(9):889-900. PMID:32661320