• Title Professor of Biochemistry and Biology
    Director, Center for Network Systems Biology
  • Education PhD: Molecular Biology, University of Toronto
  • Office K3
  • Phone 617-358-4511
  • Area of Interest Molecular Interaction Networks, Precision Mass Spectrometry, Proteomics, Functional Genomics, Bioinformatics, Systems Biology

Charting the molecular networks of cells and tissues
My laboratory develops and applies advanced proteomic, molecular genetic, genomic and bioinformatic technologies to investigate the molecular associations and biological roles of the many varied macromolecules present in different cells, tissues and organisms. Our research team has outstanding skills in state-of-the-art protein mass spectrometry and other high-throughput techniques for investigating molecular interaction networks in a global systems-wide manner. Our group aims to generate comprehensive maps of the physical and functional “interactomes” of informative models, ranging from unicellular microbes like yeast or the bacterium E. coli to more complex metazoans such as worm, mouse and (increasingly) human. We expect these maps will lead to breakthrough mechanistic understanding of how cells and tissues function at a fundamental molecular level, and serve as valuable resources for the broader research community. Ultimately, our team aims to translate this basic knowledge into novel diagnostic and therapeutic tools, with an emphasis on cancer, cardiovascular disease and neurodegenerative disorders.

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