{"id":18571,"date":"2024-03-01T13:39:21","date_gmt":"2024-03-01T18:39:21","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/?post_type=profile&p=18571"},"modified":"2026-05-29T14:23:13","modified_gmt":"2026-05-29T18:23:13","slug":"sahana-mitra","status":"publish","type":"profile","link":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/profiles\/sahana-mitra\/","title":{"rendered":"Sahana Mitra"},"content":{"rendered":"

I did my Ph.D. in Biochemistry at Bose Institute, India. During my Ph.D., I explored the role of heat shock protein 90 in regulating MAPK signaling. Subsequently, I joined as a postdoc at New York University (NYU) to pursue my research work to understand Unfolded Protein Response (UPR) in controlling the transcriptional dynamics during age-related eye disorders using genetics and molecular biology in fruit flies and human cell lines respectively.<\/p>\n

At present, in Dr. Perissi’s lab, I am exploring the principles governing the translocation of mitochondria-based transcription factors from mitochondria to the nucleus during retrograde stress signaling. The current project also focuses on the landscape study of chromatin remodeling during mitochondrial stress signaling. In a parallel project, I am also trying to uncover the role of stress-induced PARylation activity in neurogenesis and age-related neurodegeneration using fruit flies and human iPSC cells as a model system.<\/p>\n

Mentoring is my second favorite thing in Science, doing Science itself being the first.<\/p>\n

Representative Publications<\/h4>
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  1. Sahana Mitra# and Hyung Don Ryoo. The Role of Ire1 in Drosophila Eye Pigmentation Revealed by an RNase Dead Allele (Developmental Biology, doi: 10.1016\/j.ydbio.2021.07.008<\/li>\n
  2. Brian Brown#, Sahana Mitra#, Finnegan D. Roach, Deepika Vasudevan and Hyung Don Ryoo. The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila (Elife, doi: 10.7554\/eLife.74047, # Equal contribution)<\/li>\n
  3. Sahana Mitra#, Shanmugapriya Shanmugapriya#, Eveline Santos and Mojgan Naghavi. HIV-1 exploits CLASP2 to induce microtubule stabilization and facilitate virus trafficking to the nucleus (Journal of Virology, doi:10.1128\/JVI.00404-20, # Equal contribution)<\/li>\n
  4. Sahana Mitra# and Hyung Don Ryoo. The unfolded protein response in metazoan development (Journal of Cell Science, doi: 10.1242\/jcs.217216)<\/li>\n
  5. Shahana Mitra#, Baijayanti Ghosh, Nilanjan Gayen, Joydeep Roy and Atin Kumar Mandal, Bipartite role of Hsp90 keeps CRAF kinase poised for activation (Journal Biological Chemistry, doi: 10.1074\/jbc.M116.746420)<\/li>\n
  6. Nilanjan Gayen#, Sahana Mitra#, Somesh Roy and Atin Kumar Mandal. Hsp70\/Hsp90 organizing protein (HOP) maintains CRAF activity and regulates MAPK signaling by enhancing Hsp90-CRAF association(bioRxiv 2023.02.17.528950; doi: https:\/\/doi.org\/10.1101\/2023.02.17.52<\/a> 8950, Manuscript in communication, # Equal contribution)<\/li>\n
  7. Joydeep Roy, Sahana Mitra# and Atin Kumar Mandal. Hsp70 clears misfolded kinases that are partitioned into distinct quality-control compartments (Molecular Biology of Cell, 26(9): p. 1583-1600,)<\/li>\n<\/ol>\n

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