{"id":18557,"date":"2024-02-12T13:22:33","date_gmt":"2024-02-12T18:22:33","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/?post_type=profile&#038;p=18557"},"modified":"2024-02-12T13:22:33","modified_gmt":"2024-02-12T18:22:33","slug":"akshay-sharma","status":"publish","type":"profile","link":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/profiles\/akshay-sharma\/","title":{"rendered":"Akshay Sharma"},"content":{"rendered":"<p>I am currently working as a postdoctoral associate in the laboratory of Dr. Mikel Garcia-Marcos. My current research in the lab focused on two aspects, firstly to generate new tools to study G protein activation and signalling. My second aim is to identify of novel G protein binding peptides to leverage them as tools for studying G protein function.<\/p>\n<p>My previous postdoctoral research experience has been in the field of calcium signalling in the context of skin pigmentation, where I helped identify the key melanogenic protein MITF as the transcriptional regulator of the ER calcium sensor STIM1. I also looked at the role of mitochondrial calcium homeostatsis in regulating pigmentation.<\/p>\n<p>My Ph.D. research focused on studying the transcriptional regulation of E3 ubiquitin ligases in the context of breast cancer and identified SOX4 as novel regulator of the tumor suppressor E3 ligase FBXW7.<\/p>\n","protected":false},"author":8106,"template":"","tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/profile\/18557"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/profile"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/types\/profile"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/users\/8106"}],"version-history":[{"count":1,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/profile\/18557\/revisions"}],"predecessor-version":[{"id":18559,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/profile\/18557\/revisions\/18559"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/media?parent=18557"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/tags?post=18557"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}