I am currently a Postdoctoral Associate in the laboratory of Dr. Mohsan Saeed at the Department of Biochemistry and the National Emerging Infectious Diseases Laboratories (NEIDL) of Boston University.<\/p>\n
For my Ph.D. degree in Preventive Veterinary Medicine at Huazhong Agricultural University, I studied the molecular details of how animal coronaviruses, such as porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV) evade host innate immune responses. In addition, I employed proteomics, RNA sequencing, and advanced molecular biology approaches to probe the mechanisms through which gastrointestinal coronaviruses caused severe inflammation.<\/p>\n
I joined the Saeed lab in September 2022. One of my ongoing projects is to explore the function of SARS-CoV2 ORF9b in virus infected cells. Both host and viral targets of ORF9b were identified by employing proximity-based protein labeling and immunoprecipitation coupled with Mass spectrometry. I am deciphering the mechanism and contribution of ORF9b to pathogenesis by employing molecular biology approaches, based on the targets interacted with ORF9b. This research will provide a mechanistic basis for SARS-CoV-2 pathogenesis.<\/p>\n
Another project is focus on dissecting the ways in which 2A protease of enteroviruses, such as coxsackieviruses, blunt the interferon response pathway in virus-infected cells. To answer this question, my research is utilizing systems-level strategies, including degradomics and proximity-based protein labeling. These studies are expected to provide unparalleled insights into the enterovirus biology.<\/p>\n","protected":false},"author":8106,"template":"","tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/profile\/18041"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/profile"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/types\/profile"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/users\/8106"}],"version-history":[{"count":3,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/profile\/18041\/revisions"}],"predecessor-version":[{"id":18986,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/profile\/18041\/revisions\/18986"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/media?parent=18041"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/tags?post=18041"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}