{"id":17778,"date":"2022-06-06T10:13:42","date_gmt":"2022-06-06T14:13:42","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/?post_type=profile&p=17778"},"modified":"2026-04-21T09:47:28","modified_gmt":"2026-04-21T13:47:28","slug":"cheyanne-frosti","status":"publish","type":"profile","link":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/profiles\/cheyanne-frosti\/","title":{"rendered":"Cheyanne Frosti"},"content":{"rendered":"

My research career began at Loyola University of Chicago where I majored in biochemistry. As a Women in Science Engaging Research (WISER) fellow, I worked in the lab of Dr. Ken Olsen researching hemoglobin based blood substitutes. After my undergraduate degree, I pursed a master’s degree in kinesiology from the University of Central Florida researching the role of IL-6 on the AKT pathways in rotentone models of Parkinson\u2019s disease.<\/span>

My goal as a researcher has always been to integrate basic and applied science to better serve the ideas of exercise\/nutritional interventions while developing preventative approaches to human disease. With my goals in mind, I joined the lab of Dr. Matt Layne as a Ph.D. student in the summer of 2022 where I focus on fibrosis, mechanical stiffness, and intracellular signaling of adipose tissue.<\/span><\/p>\n

Publications<\/h4>
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  1. Frosti CL<\/strong>, Yeritsyan D, Layne MD. Aortic carboxypeptidase-like protein potentiates \u03b21 integrin signaling in mesenchymal progenitors. Life Science Alliance, 2026 Apr8;9(6):e202503600.\u00a0<\/a><\/li>\n
  2. Frosti CL<\/strong>, Connelly SP, Layne MD. Mechanobiology of Adipose Tissue Remodeling. Tissue Engineering, Part A. 2025. in press.<\/li>\n
  3. Seibel AJ,\u00a0<\/span>Frosti CL<\/strong>, Tlemcani AR, Lahiri N, Brammer-DePuy JA,\u00a0Layne MD, Tien J. Obesity-Associated Conditions Hinder Solute Drainage Function of Engineered Human Lymphatic Vessels. Cell Mol Bioeng. 2025 Jan 23;18(1):53-69. doi: 10.1007\/s12195-024-00840-z.<\/span><\/li>\n
  4. Wells AJ, Varanoske AN, Coker NA, Kozlowski GJ, Gepner Y, Frosti CL<\/strong>, Boffey D, Harat I, Hoffman JR. (2020). Changes in cognition during a 24-h simulated military operation. Role of classical monocytes and beta- alanine. Medicine & Science in Sports and Exercise. 52(5): S522. DOI: 10.1249\/01.mss.0000682348.93835.38<\/li>\n
  5. Wells AJ, Varanoske AN, Kozlowski G, Frosti CL<\/strong>, Boffey D, Coker NA, Harat I, Jahani S, Gepner Y, Hoffman JR. (2020). The effect of \u03b2-alanine supplementation on monocyte recruitment and cognition during a 24-h simulated military operation (SUSOP). Journal of Strength & Conditioning Research. DOI: 10.1519\/JSC.0000000000003809<\/li>\n
  6. Varanoske, A.N., Wells, A.J., Boffey, D., Harat, I., Frosti, C.L., Kozlowski, G., Gepner, Y. & Hoffman, J.R. (2020). The effects of high-dose, short-duration \u03b2-alanine supplementation on cognitive function, mood, and circulating brain-derived neurotropic factor (BDNF) in recreationally active males before military operational stress. Journal of Dietary Supplements. 6:1-22. DOI: 10.1080\/19390211.2020.1733730.<\/li>\n
  7. Varanoske, A.N., Wells, A.J., Kozlowski, G.J., Gepner, Y., Frosti, C.L., Boffey, D., Coker, N.A., Harat, I., & Hoffman, J.R. (2018). Effects of \u03b2-alanine supplementation on physical performance, cognition, endocrine function, and inflammation during a 24-hr simulated military operation. Physiology Reports. 6(24): e13938. DOI: 10.14814\/phy2.13938.<\/li>\n
  8. David Boffey, Idan Harat, Cheyanne L Frosti, Yftach Gepner, Shany Funk, Jay R. Hoffman. (2018). The Physiology and Biomechanics of Load Carriage Performance. Military Medicine. 184(1-2): e83-e90. DOI: 10.1093\/milmed\/usy218.<\/li>\n
  9. Webster, K. D., Dahhan, D., Otto, A. M., Frosti, C.L., Dean, W. L., Chaires, J. B. and Olsen, K. W. (2017). \u201cInside-Out\u201d PEGylation of Bovine \u03b2-Cross-Linked Hemoglobin. Artificial Organs. 41(4):351-358. DOI: 10.1111\/aor.12928.<\/li>\n<\/ol>\n

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