{"id":17761,"date":"2022-06-03T11:23:17","date_gmt":"2022-06-03T15:23:17","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/?post_type=profile&#038;p=17761"},"modified":"2025-12-23T10:28:44","modified_gmt":"2025-12-23T15:28:44","slug":"emily-sparago","status":"publish","type":"profile","link":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/profiles\/emily-sparago\/","title":{"rendered":"Emily Sparago"},"content":{"rendered":"<p><span>I am a graduate student in Dr. Mike Blower&#8217;s lab. My research focuses on the stability of Xist, the long non-coding RNA which inactivates one X chromosome in XX (female) cells, throughout the cell cycle.<\/span><\/p>\n<p>I graduated from Quinnipiac University in 2020 with a degree in Biology and Chemistry. From 2018-2020, I interned at Yale University School of Medicine, where I was afforded the opportunity to join the lab of Dr. W. Mark Saltzman to study the biodistribution of PLGA nanoparticles in a mouse model. Later, I researched in Dr. Peter Glazer&#8217;s lab utilizing PNA\/DNA-loaded nanoparticles to correct Sickle Cell Disease. I am eager to learn more at Boston University School of Medicine as I pursue my PhD.<\/p>\n<p><span class=\"s1\"><div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h4 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Publications<\/h4><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/span><\/p>\n<ul>\n<li>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublication_ctl03_lblPublication\">Sharp JA, Sparago E, Thomas R, Alimenti K, Wang W, Blower MD. Role of the SAF-A\/HNRNPU SAP domain in X chromosome inactivation, nuclear dynamics, transcription, splicing, and cell proliferation. PLoS Genet. 2025 Jun; 21(6):e1011719. PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/40493679\" target=\"_blank\" rel=\"noopener\">40493679<\/a>; PMCID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12176297\" target=\"_blank\" rel=\"noopener\">PMC12176297<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1371\/journal.pgen.1011719\" target=\"_blank\" rel=\"noopener\">10.1371\/journal.pgen.1011719<\/a><\/span><\/div>\n<\/li>\n<li><span>Mandl HK, Quijano E, Suh HW, Sparago E, Oeck S, Grun M, Glazer PM, Saltzman WM. Optimizing biodegradable nanoparticle size for tissue-specific delivery. J Control Release. 2019 Nov 28;314:92-101. doi: 10.1016\/j.jconrel.2019.09.020. Epub 2019 Oct 22. PMID: 31654688; PMCID: PMC6909251.<\/span><\/li>\n<\/ul>\n<p><span class=\"s1\"><\/div>\n<\/div>\n<\/span><\/p>\n","protected":false},"author":17297,"template":"","tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/profile\/17761"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/profile"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/types\/profile"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/users\/17297"}],"version-history":[{"count":3,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/profile\/17761\/revisions"}],"predecessor-version":[{"id":19557,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/profile\/17761\/revisions\/19557"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/media?parent=17761"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/tags?post=17761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}