{"id":19668,"date":"2026-02-13T09:55:04","date_gmt":"2026-02-13T14:55:04","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/?p=19668"},"modified":"2026-02-13T09:55:04","modified_gmt":"2026-02-13T14:55:04","slug":"new-publication-from-the-garcia-marcos-lab-inhibitory-probes-for-spatiotemporal-analysis-of-g%ce%b1s-protein-signaling","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/2026\/02\/13\/new-publication-from-the-garcia-marcos-lab-inhibitory-probes-for-spatiotemporal-analysis-of-g%ce%b1s-protein-signaling\/","title":{"rendered":"New publication from the Garcia-Marcos Lab: Inhibitory probes for spatiotemporal analysis of G\u03b1s protein signaling"},"content":{"rendered":"<p><strong>NEW PUBLICATION BY THE GARCIA-MARCOS LAB<\/strong><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41589-025-02138-1\"><img loading=\"lazy\" src=\"\/biochemcellbio\/files\/2026\/02\/Graph-Abstract_biochem-web.png\" alt=\"\" width=\"132\" height=\"129\" class=\"alignleft  wp-image-19669\" srcset=\"https:\/\/www.bumc.bu.edu\/biochemcellbio\/files\/2026\/02\/Graph-Abstract_biochem-web.png 596w, https:\/\/www.bumc.bu.edu\/biochemcellbio\/files\/2026\/02\/Graph-Abstract_biochem-web-310x300.png 310w\" sizes=\"(max-width: 132px) 100vw, 132px\" \/><\/a><\/p>\n<p>A recent publication in <em>Nature Chemical Biology<\/em> (<a href=\"https:\/\/www.nature.com\/articles\/s41589-025-02138-1\">https:\/\/www.nature.com\/articles\/s41589-025-02138-1<\/a>) led by Jingyi Zhao in the Garcia-Marcos Lab describes the discovery and optimization of broadly applicable genetically-encoded probes and peptide-based compounds specifically inhibit G\u03b1s, the prototypical signal transducer of G protein-coupled receptors (GPCRs). These tools were leveraged to provide new mechanistic insights into GPCR signaling at the subcellular scale by revealing definitive evidence for G protein signaling at endosomes. The newly developed peptide-based compound named \u03b1-sintide allowed the inhibition signaling in multiple contexts: blocking an oncogenic G protein mutant, inhibiting heart cell responses to adrenaline, or preventing T cell exhaustion.<\/p>\n<p>&nbsp;<\/p>\n<p>This work was done in collaboration with the Varelas Lab in our Department and with the Irannejad Lab and Vilardaga Lab at UCSF and U of Pittsburgh, respectively.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>NEW PUBLICATION BY THE GARCIA-MARCOS LAB A recent publication in Nature Chemical Biology (https:\/\/www.nature.com\/articles\/s41589-025-02138-1) led by Jingyi Zhao in the [&hellip;]<\/p>\n","protected":false},"author":8106,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[104,4654],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/19668"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/users\/8106"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/comments?post=19668"}],"version-history":[{"count":2,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/19668\/revisions"}],"predecessor-version":[{"id":19671,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/19668\/revisions\/19671"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/media?parent=19668"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/categories?post=19668"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/tags?post=19668"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}