{"id":19253,"date":"2025-08-06T08:59:25","date_gmt":"2025-08-06T12:59:25","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/?p=19253"},"modified":"2026-01-07T15:12:14","modified_gmt":"2026-01-07T20:12:14","slug":"new-research-from-the-layne-lab-mechanisms-of-adipose-tissue-fibrosis","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/2025\/08\/06\/new-research-from-the-layne-lab-mechanisms-of-adipose-tissue-fibrosis\/","title":{"rendered":"New Research from the Layne Lab: mechanisms of adipose tissue fibrosis"},"content":{"rendered":"<p>A new study from the Layne laboratory identified a function for the transcription factor FOXS1 in regulating TGFb-dependent changes in adipogenic differentiation: <a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(25)02414-7\/fulltext\">JBC in press.\u00a0<\/a><\/p>\n<p><span>White adipose tissue (WAT) fibrosis is a major determinant of obesity-induced dysfunction and is characterized by excessive extracellular matrix deposition and myofibroblast activation. In this study, first author Alexander Tavares and co-authors identified FOXS1, a member of the forkhead box transcription factor superfamily, as a transcriptional target of TGF-\u03b21 signaling in primary human adipocyte stem cells. \u00a0FOXS1 also attenuated the induction of several adipogenic factors and sensitized cells to the anti-adipogenic effects of TGF-\u03b21. Furthermore, loss of endogenous FOXS1 improved adipogenic permissiveness and activated proadipogenic gene programs in progenitors, even after TGF-\u03b21 stimulation. These results indicate that FOXS1 is a positive regulator of profibrotic TGF-\u03b21-dependent cellular responses, orchestrating the regulation of molecular phenotypes that promote myofibroblast activation and block adipogenesis. Co-authors in this study from the Layne lab include Scott Connelly, Daryn Maksat, Jane Zheng and Nabil Rabhi from the Farmer lab.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study from the Layne laboratory identified a function for the transcription factor FOXS1 in regulating TGFb-dependent changes in [&hellip;]<\/p>\n","protected":false},"author":1191,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[104,100],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/19253"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/users\/1191"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/comments?post=19253"}],"version-history":[{"count":4,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/19253\/revisions"}],"predecessor-version":[{"id":19255,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/19253\/revisions\/19255"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/media?parent=19253"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/categories?post=19253"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/tags?post=19253"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}