{"id":15220,"date":"2020-03-19T04:41:46","date_gmt":"2020-03-19T08:41:46","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/?p=15220"},"modified":"2026-01-07T15:14:00","modified_gmt":"2026-01-07T20:14:00","slug":"new-research-discoveries-a-microrna-451-makes-blood","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/2020\/03\/19\/new-research-discoveries-a-microrna-451-makes-blood\/","title":{"rendered":"New research discoveries: A small RNA makes blood"},"content":{"rendered":"<p>Recent research from the Cifuentes laboratory that describes the functional role of a non-canonical microRNA-processing pathway has been published in Molecular Cell: <strong><a href=\"https:\/\/www.cell.com\/molecular-cell\/fulltext\/S1097-2765(20)30113-1\">Ago2-Dependent Processing Allows miR-451 to Evade the Global MicroRNA Turnover Elicited during Erythropoiesis<\/a><a href=\"https:\/\/www.bumc.bu.edu\/biochemcellbio\/2020\/03\/19\/new-research-discoveries-a-microrna-451-makes-blood\/figure-blood\/\" rel=\"attachment wp-att-15224\"><img loading=\"lazy\" src=\"\/biochemcellbio\/files\/2020\/03\/Figure-blood-344x300.png\" alt=\"\" width=\"344\" height=\"300\" class=\"alignright size-medium wp-image-15224\" srcset=\"https:\/\/www.bumc.bu.edu\/biochemcellbio\/files\/2020\/03\/Figure-blood-344x300.png 344w, https:\/\/www.bumc.bu.edu\/biochemcellbio\/files\/2020\/03\/Figure-blood.png 607w\" sizes=\"(max-width: 344px) 100vw, 344px\" \/><\/a><a href=\"https:\/\/www.cell.com\/molecular-cell\/fulltext\/S1097-2765(20)30113-1\"><\/a><\/strong><\/p>\n<p>The work spearheaded by the Cifuentes\u2019 laboratory postdoc Dmitry Kretov addresses a long-standing question that has puzzled developmental biologists beyond microRNA aficionados:\u00a0 Why miR-451, a vertebrate-specific microRNA expressed in red blood cells, uses an alternative processing pathway that bypasses Dicer but instead relies on the slicer activity of Ago2?<\/p>\n<p>Kretov <em>et al.,<\/em> report that miR-451 uses this non-canonical processing pathway to escape the global downregulation of microRNAs and Dicer that occurs during erythropoiesis, triggered in part by a negative-feedback loop between miR-144 and Dicer.<\/p>\n<p>Overall, this study uncovers the evolutionary relevance of the non-canonical processing of miR-451 and it highlights a novel physiological role of miR-144, with important clinical implications for the study of anemia and the differentiation of red blood cells.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Recent research from the Cifuentes laboratory that describes the functional role of a non-canonical microRNA-processing pathway has been published in [&hellip;]<\/p>\n","protected":false},"author":1191,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[104,100],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/15220"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/users\/1191"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/comments?post=15220"}],"version-history":[{"count":6,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/15220\/revisions"}],"predecessor-version":[{"id":15230,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/15220\/revisions\/15230"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/media?parent=15220"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/categories?post=15220"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/tags?post=15220"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}