{"id":14415,"date":"2019-05-14T10:12:57","date_gmt":"2019-05-14T14:12:57","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/?p=14415"},"modified":"2026-01-07T15:14:17","modified_gmt":"2026-01-07T20:14:17","slug":"research-discoveries-new-ways-of-activating-g-proteins-during-embryonic-development","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/2019\/05\/14\/research-discoveries-new-ways-of-activating-g-proteins-during-embryonic-development\/","title":{"rendered":"Research Discoveries: New ways of activating G-proteins during embryonic development"},"content":{"rendered":"<p class=\"p1\">Heterotrimeric G proteins are signaling switches that control cellular communication <a href=\"https:\/\/www.bumc.bu.edu\/biochemcellbio\/2019\/05\/14\/research-discoveries-new-ways-of-activating-g-proteins-during-embryonic-development\/arthurweb\/\" rel=\"attachment wp-att-14417\"><img loading=\"lazy\" src=\"\/biochemcellbio\/files\/2019\/05\/ArthurWeb-579x300.jpg\" alt=\"\" width=\"389\" height=\"205\" class=\"alignright wp-image-14417\" \/><\/a>across metazoans. From a traditional standpoint, these G-proteins are activated by G-protein-coupled receptors (GPCRs). However, a recent paper published in the <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30948426\"><i>Journal of Cell Biology<\/i> <\/a>by Arthur Marivin and colleagues provides direct evidence that heterotrimeric G-proteins can be activated <i>in vivo<\/i> by a cytoplasmic factor instead of by a GPCR. Specifically, DAPLE, a non-receptor protein bearing an evolutionarily conserved G-protein activating motif, triggers apical cell constriction during neurulation in <i>Xenopus<\/i> and zebrafish embryos via G-protein dependent signaling. This project of the Garcia-Marcos Lab was carried out in collaboration with the Dominguez Lab (Dept. of Medicine) and the Cifuentes Lab (Dept. of Biochemistry) at BU.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Heterotrimeric G proteins are signaling switches that control cellular communication across metazoans. From a traditional standpoint, these G-proteins are activated [&hellip;]<\/p>\n","protected":false},"author":1191,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[104,4654,100],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/14415"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/users\/1191"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/comments?post=14415"}],"version-history":[{"count":3,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/14415\/revisions"}],"predecessor-version":[{"id":14423,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/14415\/revisions\/14423"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/media?parent=14415"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/categories?post=14415"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/tags?post=14415"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}