{"id":14077,"date":"2018-10-05T07:52:45","date_gmt":"2018-10-05T11:52:45","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/?p=14077"},"modified":"2026-01-07T15:14:27","modified_gmt":"2026-01-07T20:14:27","slug":"new-research-discoveries-prions","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/2018\/10\/05\/new-research-discoveries-prions\/","title":{"rendered":"New Research Discoveries: Prions and Synaptic Toxicity"},"content":{"rendered":"<p><a href=\"https:\/\/www.bumc.bu.edu\/biochemcellbio\/2018\/10\/05\/new-research-discoveries-actin-and-prions\/synapse-2\/\" rel=\"attachment wp-att-14079\"><img loading=\"lazy\" src=\"\/biochemcellbio\/files\/2018\/10\/synapse-300x300.png\" alt=\"\" width=\"300\" height=\"300\" class=\"alignright size-medium wp-image-14079\" srcset=\"https:\/\/www.bumc.bu.edu\/biochemcellbio\/files\/2018\/10\/synapse-300x300.png 300w, https:\/\/www.bumc.bu.edu\/biochemcellbio\/files\/2018\/10\/synapse-150x150.png 150w, https:\/\/www.bumc.bu.edu\/biochemcellbio\/files\/2018\/10\/synapse-100x100.png 100w, https:\/\/www.bumc.bu.edu\/biochemcellbio\/files\/2018\/10\/synapse.png 320w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a>In a new research study from the Harris laboratory in\u00a0<a href=\"https:\/\/journals.plos.org\/plospathogens\/article?id=10.1371\/journal.ppat.1007283\" target=\"_blank\" rel=\"noopener\">PLOS pathogens<\/a>, first author Cheng Feng and collaborators defined a new pathway mediated by the p38 MAPK signaling pathway that was important for prion synaptic toxicity. Furthermore this research identified that perturbations in the actin cytoskeleton within dendritic spines resulted in deficits in synaptic transmission.<\/p>\n<p><span><\/span><\/p>\n<p>This study has received significant press coverage and appeared on the cover of\u00a0<a href=\"https:\/\/journals.plos.org\/plospathogens\/issue?id=10.1371\/issue.ppat.v14.i09\">PLOS pathogens<\/a>.<\/p>\n<p>Congratulations Harris lab.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a new research study from the Harris laboratory in\u00a0PLOS pathogens, first author Cheng Feng and collaborators defined a new [&hellip;]<\/p>\n","protected":false},"author":1191,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[104,4658,100],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/14077"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/users\/1191"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/comments?post=14077"}],"version-history":[{"count":8,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/14077\/revisions"}],"predecessor-version":[{"id":14091,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/14077\/revisions\/14091"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/media?parent=14077"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/categories?post=14077"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/tags?post=14077"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}