{"id":13710,"date":"2018-06-01T08:40:43","date_gmt":"2018-06-01T12:40:43","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/?p=13710"},"modified":"2026-01-07T15:14:36","modified_gmt":"2026-01-07T20:14:36","slug":"research-discoveries-jello-in-your-fat","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/2018\/06\/01\/research-discoveries-jello-in-your-fat\/","title":{"rendered":"Research Discoveries: Jello in Your Fat"},"content":{"rendered":"<p>A new\u00a0study from the Layne lab &#8220;Aortic carboxypeptidase-like protein enhances adipose tissue stromal progenitor differentiation into myofibroblasts and is upregulated in fibrotic white adipose tissue<a href=\"https:\/\/www.bumc.bu.edu\/biochemcellbio\/2018\/06\/01\/research-discoveries-jello-in-your-fat\/picrofat\/\" rel=\"attachment wp-att-13711\"><img loading=\"lazy\" src=\"\/biochemcellbio\/files\/2018\/06\/picrofat-150x150.png\" alt=\"picrofat\" width=\"150\" height=\"150\" class=\"alignright size-thumbnail wp-image-13711\" srcset=\"https:\/\/www.bumc.bu.edu\/biochemcellbio\/files\/2018\/06\/picrofat-150x150.png 150w, https:\/\/www.bumc.bu.edu\/biochemcellbio\/files\/2018\/06\/picrofat-100x100.png 100w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/><\/a>&#8221; was recently published in <a href=\"http:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0197777\">PLoS One<\/a>. This research\u00a0identified a new pathway regulating of adipose tissue differentiation and fibrotic remodeling. First author and graduate student Mike Jager, along with collaborators in the Farmer and Fried labs determimed that the secreted protein Aortic Carboxypeptidase-like Protein (ACLP) repressed the differentiation of mouse and human adipocyte progenitors and was upregulated in fibrotic adipose tissue. ACLP was co-expressed with collagens in the adipose tissue and indicate that ACLP is a novel regulator of adipose progenitors and fibrosis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new\u00a0study from the Layne lab &#8220;Aortic carboxypeptidase-like protein enhances adipose tissue stromal progenitor differentiation into myofibroblasts and is upregulated [&hellip;]<\/p>\n","protected":false},"author":1191,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[104,101,100],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/13710"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/users\/1191"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/comments?post=13710"}],"version-history":[{"count":6,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/13710\/revisions"}],"predecessor-version":[{"id":13717,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/13710\/revisions\/13717"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/media?parent=13710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/categories?post=13710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/tags?post=13710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}