{"id":13090,"date":"2017-02-14T08:30:13","date_gmt":"2017-02-14T13:30:13","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/?p=13090"},"modified":"2026-01-07T15:14:58","modified_gmt":"2026-01-07T20:14:58","slug":"new-research-from-perissi-lab-gps2-and-insulin-signaling","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/2017\/02\/14\/new-research-from-perissi-lab-gps2-and-insulin-signaling\/","title":{"rendered":"New Research from Perissi Lab: GPS2 and insulin signaling"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">A new study from the Perissi lab has revealed an unexpected\u00a0layer of regulation in the insulin signaling cascade\u00a0based on the opposing actions of the ubiquitin conjugating enzyme Ubc13 and its\u00a0inhibitor GPS2. The work,\u00a0recently published in <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28123943\">Molecular Metabolism<\/a>, shows that\u00a0<\/span>Ubc13-mediated ubiquitination of\u00a0the\u00a0AKT\/PKB kinase is required for its phosphorylation and activation in the insulin signaling cascade. Conversely, loss of GPS2-mediated inhibition of Ubc13 activity promotes\u00a0<span class=\"s1\">sustained insulin signaling<\/span>\u00a0both\u00a0<i>in vitro<\/i>, in 3T3-L1 adipocytes, and\u00a0<i>in vivo<\/i>\u00a0in the adipose tissue of GPS2-AKO\u00a0mice. Dr. Valentina Perissi and Carly Cederquist, the graduate student who led the project, discuss their finding in the 60 Second Metabolist video (below)<\/p>\n<p><iframe loading=\"lazy\" width=\"260px\" height=\"176px\" src=\"\/\/player.vimeo.com\/video\/201807563?color=D43F37\" frameborder=\"0\" webkitallowfullscreen=\"webkitallowfullscreen\" mozallowfullscreen=\"mozallowfullscreen\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study from the Perissi lab has revealed an unexpected\u00a0layer of regulation in the insulin signaling cascade\u00a0based on the [&hellip;]<\/p>\n","protected":false},"author":1191,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[104,100],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/13090"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/users\/1191"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/comments?post=13090"}],"version-history":[{"count":6,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/13090\/revisions"}],"predecessor-version":[{"id":13098,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/posts\/13090\/revisions\/13098"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/media?parent=13090"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/categories?post=13090"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/tags?post=13090"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}