{"id":12096,"date":"2020-07-30T16:58:43","date_gmt":"2020-07-30T20:58:43","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/?p=12096"},"modified":"2026-01-07T15:13:52","modified_gmt":"2026-01-07T20:13:52","slug":"postdoctoral-position-garcia-marcos-lab","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/2020\/07\/30\/postdoctoral-position-garcia-marcos-lab\/","title":{"rendered":"Garcia-Marcos Laboratory"},"content":{"rendered":"

POSTDOCTORAL POSITION, CELL BIOLOGY\/ SIGNALING
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Our laboratory investigates signal transduction mechanisms with the ultimate goal of elucidating the molecular basis of human diseases and developing novel therapeutic approaches. Our main interest is in heterotrimeric G proteins, which are molecular switches primarily activated by G protein-coupled receptors (GPCRs) located at the plasma membrane. In the recent years, we have pioneered the characterization of novel mechanisms of G protein regulation that deviate from the canon and that have important implications in cancer, embryonic development, and neurotransmission. Our multidisciplinary approach includes\u00a0<\/span>in vitro<\/em>\u00a0<\/span>biochemistry to characterize protein complexes, culture cells and model organisms (yeast, frog embryos) for functional studies and synthetic biology tools to manipulate and monitor signaling with exquisite spatiotemporal resolution and fidelity.<\/p>\n

There are several open projects in the laboratory that could accommodate new postdoctoral fellows. These involve the study of spatiotemporal control of\u00a0<\/span>GPCR<\/span>\/ G protein signaling with live-cell biosensors and other synthetic biology tools, and investigating the role of\u00a0<\/span>GPCR<\/span>-independent G protein signaling in epithelial tissues\u00a0<\/span>in vitro<\/em>\u00a0<\/span>and vertebrate embryos (zebrafish,\u00a0<\/span>Xenopus<\/em>)\u00a0<\/span>in vivo<\/em>. It is also expected that the applicant will be engaged in related secondary projects and collaborative efforts within and\/or outside our laboratory.<\/p>\n

QUALIFICATIONS<\/span>\u00a0<\/span>REQUIRED<\/span>–<\/strong>\u00a0<\/span>We are looking for candidates with a recent Ph.D. and experience in\u00a0<\/span>Cell Biology and Biochemistry<\/strong>, as demonstrated by a strong publication record. Prior knowledge of\u00a0<\/span>GPCR<\/span>\/G protein signal transduction is preferred but not essential. We are looking for\u00a0<\/span>motivated<\/strong>\u00a0<\/span>and\u00a0<\/span>creative<\/strong>\u00a0<\/span>individuals with a commitment to academic research who can work\u00a0<\/span>independently<\/strong>\u00a0<\/span>as well as in\u00a0<\/span>team-based<\/strong>\u00a0<\/span>projects. Good oral and written communication skill are a must.<\/p>\n

The atmosphere in the laboratory is\u00a0<\/span>collaborative\u00a0<\/span><\/strong>and\u00a0<\/span>multidisciplinary<\/strong>. The successful candidate will interact on a daily basis with colleagues carrying out studies on different areas of research (cancer, development, neurobiology) and approaches (purified proteins, structural biology, primary and cell line cultures,\u00a0<\/span>BRET<\/span>, mice, frogs, etc). Our laboratory is highly committed to the career development of trainees.<\/p>\n

The Department of Biochemistry at Boston University offers a highly collegial atmosphere and a first rate research environment.<\/p>\n

Skills:<\/strong>\u00a0<\/span>Experience with several of the techniques listed below is required:<\/p>\n