{"id":376,"date":"2016-07-13T12:34:48","date_gmt":"2016-07-13T16:34:48","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/?page_id=376"},"modified":"2024-08-30T12:31:08","modified_gmt":"2024-08-30T16:31:08","slug":"cellbiology","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/research\/cellbiology\/","title":{"rendered":"Cell Biology"},"content":{"rendered":"<p><span style=\"color: black;\">Cell biology aims to understand the structure and function of individual cells, how they interact with their environment, and how cells coordinate with each other to form tissues and organisms. Additionally, cell biology strives to understand the functions of individual molecules within cells and how they interact with the intracellular environment.<o:p><\/o:p><\/span><\/p>\n<p><span style=\"color: black;\">Projects in our department explore: cellular and molecular pathways that drive cell proliferation, differentiation, signaling, migration, metabolism, autophagy, and more. We use different model systems for our studies, ranging from cell lines and organotypic cultures to various animal models and combine diverse experimental approaches including a wide variety of cell-based assays, quantitative microscopy, molecular biology, genetics and genomics, biochemistry, genome engineering and <em>in vivo<\/em> studies. A major focus of our studies is on understanding the underlying cause of wide-spread human disease including diabetes, cancer, inflammation and fibrosis.<o:p><\/o:p><\/span><\/p>\n<p><span style=\"color: black;\">More information on the individual projects can be found under the links below.<o:p><\/o:p><\/span><\/p>\n<h3 style=\"text-align: left;\">Faculty conducting research in these areas:<\/h3>\n<p style=\"text-align: left;\">\n\t<div class=\"profile-listing\">\n\t\t<ul class=\"advanced\">\n\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bumc.bu.edu\/biochemcellbio\/profiles\/michael-blower\/\">\n\t\t\t\t\t<figure><img width=\"150\" height=\"150\" src=\"\/biochemcellbio\/files\/2020\/07\/Blower_202-1-150x150.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Michael Blower<\/p>\n\t\t<p class=\"profile-title\">Professor<br \/>\r\nDirector, Biochemistry &#038; Cell Biology Graduate Program<\/p>\t\t\t\t\t\t\t\t\t<p class=\"profile-interest\">Mitosis, transcription, chromatin structure<\/p>\t\t\t\t\t\t\t\t\t\t<\/a>\n<\/li>\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bumc.bu.edu\/biochemcellbio\/profiles\/mikel-garcia-marcos\/\">\n\t\t\t\t\t<figure><img width=\"133\" height=\"150\" src=\"\/biochemcellbio\/files\/2016\/07\/IMG_6574.jpeg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Mikel Garcia-Marcos<\/p>\n\t\t<p class=\"profile-title\">Professor of Biochemistry &#038; Cell Biology<br \/>\r\nProfessor of Biology<\/p>\t\t\t\t\t\t\t\t\t<p class=\"profile-interest\">G protein signaling circuits in the molecular basis of disease<\/p>\t\t\t\t\t\t\t\t\t\t<\/a>\n<\/li>\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bumc.bu.edu\/biochemcellbio\/profiles\/stefan-isaac\/\">\n\t\t\t\t\t<figure><img width=\"150\" height=\"150\" src=\"\/biochemcellbio\/files\/2024\/05\/RSI_Headshot-150x150.png\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Stefan Isaac<\/p>\n\t\t<p class=\"profile-title\">Assistant Professor<\/p>\t\t\t\t\t\t\t\t\t<p class=\"profile-interest\">Mitochondrial genome packaging and regulation<\/p>\t\t\t\t\t\t\t\t\t\t<\/a>\n<\/li>\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bumc.bu.edu\/biochemcellbio\/profiles\/matthew-d-layne\/\">\n\t\t\t\t\t<figure><img width=\"150\" height=\"150\" src=\"\/biochemcellbio\/files\/2024\/03\/layne2023-150x150.png\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Matthew D. Layne<\/p>\n\t\t<p class=\"profile-title\">Associate Professor<br \/>\r\nAssistant Dean of Research<\/p>\t\t\t\t\t\t\t\t\t<p class=\"profile-interest\">Adipose tissue fibrosis, mechanotransduction, &#038; EDS syndrome<\/p>\t\t\t\t\t\t\t\t\t\t<\/a>\n<\/li>\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bumc.bu.edu\/biochemcellbio\/profiles\/shawn-lyons\/\">\n\t\t\t\t\t<figure><img width=\"150\" height=\"150\" src=\"\/biochemcellbio\/files\/2019\/06\/Lyons-Headshot-1.jpeg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Shawn Lyons<\/p>\n\t\t<p class=\"profile-title\">Assistant Professor<\/p>\t\t\t\t\t\t\t\t\t<p class=\"profile-interest\">RNA metabolism during stress<\/p>\t\t\t\t\t\t\t\t\t\t<\/a>\n<\/li>\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bumc.bu.edu\/biochemcellbio\/profiles\/valentina-perissi\/\">\n\t\t\t\t\t<figure><img width=\"150\" height=\"150\" src=\"\/biochemcellbio\/files\/2017\/01\/VP2017-150x150.png\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Valentina Perissi<\/p>\n\t\t<p class=\"profile-title\">Associate Professor<\/p>\t\t\t\t\t\t\t\t\t<p class=\"profile-interest\">Genomic Regulation of Metabolism, Nuclear-Mitochondria Communication<\/p>\t\t\t\t\t\t\t\t\t\t<\/a>\n<\/li>\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bumc.bu.edu\/biochemcellbio\/profiles\/mohsan-saeed\/\">\n\t\t\t\t\t<figure><img width=\"150\" height=\"143\" src=\"\/biochemcellbio\/files\/2020\/12\/Screen-Shot-2020-12-20-at-9.22.31-AM-314x300.png\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Mohsan Saeed<\/p>\n\t\t<p class=\"profile-title\">Associate Professor<br \/>\r\nInvestigator, NEIDL<\/p>\t\t\t\t\t\t\t\t\t<p class=\"profile-interest\">Role of viral proteases in shaping virus-host interactions<\/p>\t\t\t\t\t\t\t\t\t\t<\/a>\n<\/li>\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bumc.bu.edu\/biochemcellbio\/profiles\/vickery-trinkaus-randall\/\">\n\t\t\t\t\t<figure><img width=\"150\" height=\"150\" src=\"\/biochemcellbio\/files\/2016\/07\/Trinkaus-Randall-Vickery-150x150.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Vickery Trinkaus-Randall<\/p>\n\t\t<p class=\"profile-title\">Professor<\/p>\t\t\t\t\t\t\t\t\t<p class=\"profile-interest\">purinoreceptors, EGFR receptors, confocal imaging, wound repair, cell communication and migration<\/p>\t\t\t\t\t\t\t\t\t\t<\/a>\n<\/li>\t\t\t\t\t\t\t\n<li class=\"has-title\">\n\t<a href=\"https:\/\/www.bumc.bu.edu\/biochemcellbio\/profiles\/bob-xaralabos-varelas\/\">\n\t\t\t\t\t<figure><img width=\"128\" height=\"150\" src=\"\/biochemcellbio\/files\/2016\/07\/Varelas_Bob-c-255x300.jpg\" alt=\"\" \/><\/figure>\t\t\t\t<p class=\"profile-name\">Xaralabos (Bob) Varelas<\/p>\n\t\t<p class=\"profile-title\">Professor<\/p>\t\t\t\t\t\t\t\t\t<p class=\"profile-interest\">Hippo-YAP\/TAZ Signaling, Lung Epithelial Biology, Cancer Biology, Tissue Regeneration and Fibrosis, Immune Cell Functions<\/p>\t\t\t\t\t\t\t\t\t\t<\/a>\n<\/li>\t\t\t\t\t<\/ul>\n\t<\/div><!--\/.profile-listing-->\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cell biology aims to understand the structure and function of individual cells, how they interact with their environment, and how [&hellip;]<\/p>\n","protected":false},"author":1191,"featured_media":0,"parent":10,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/pages\/376"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/users\/1191"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/comments?post=376"}],"version-history":[{"count":51,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/pages\/376\/revisions"}],"predecessor-version":[{"id":19000,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/pages\/376\/revisions\/19000"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/pages\/10"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/wp-json\/wp\/v2\/media?parent=376"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}