{"id":264,"date":"2008-09-08T10:32:47","date_gmt":"2008-09-08T14:32:47","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/?page_id=264"},"modified":"2025-02-09T07:25:33","modified_gmt":"2025-02-09T12:25:33","slug":"proteomics-glycomics","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/biochemcellbio\/research\/proteomics-glycomics\/","title":{"rendered":"Proteomics & Glycomics"},"content":{"rendered":"

Proteomics:\u00a0<\/strong>We\u00a0use of mass spectrometric methods for determining patterns of protein expression in biological systems. Effort is underway to develop proteomics methods and apply these to collaborations at BUMC and around the world. Active\u00a0projects include: targeted proteomics for detecting cardiovascular disease and metabolic causes &\u00a0Imaging mass spectrometry of brain tissue in neurological diseases<\/span><\/p>\n

Glycoproteomics:\u00a0<\/strong>Involves the study of structural and functional aspects of protein glycosylation.\u00a0 Many mammalian proteins contain glycan binding domains that interact with specific classes (known as epitopes) of glycoprotein glycans. The functions of glycoproteins, by virtue of the proteins to which they bind, depend heavily on context-depended glycans with which they are modified.\u00a0 Effort is underway to develop and apply effective methods for glycoprotein analysis to meet the needs of biomedicine. <\/span><\/p>\n

Glycomics: <\/strong>We are studying of the structures and functions of glycans in biological systems. Glycans function in biomedicine according to the proteins (or protein domains) to which they bind. All cells are coated with a dense layer of glycans, through which all molecular interactions take place. \u00a0Effort is underway to develop and apply methods for analyzing glycans related to human disease questions.\u00a0 Projects include:\u00a0Glycomics of glycosaminoglycan,\u00a0Elucidation of the glycan structures of methanogenic archaea,\u00a0Identification of glycans in human milk that are protective against HIV infection,\u00a0Activated electron dissociation tandem mass spectrometry of glycans,\u00a0Development of software for interpretation of glycan mass spectra.<\/span><\/p>\n

Center for Biomedical Mass Spectrometry (CBMS<\/u><\/a>):<\/strong> The Boston University Center for Biomedical Mass Spectrometry joins three basic sciences research units under one roof. CMBS develops and applies high-end instrumentation and methods, and its faculty collaborate extensively with other biomedical researchers at BUSM and elsewhere. The primary goal of the Center is to develop and disseminate methods and instrumentation to meet emerging bioanalytical needs.<\/p>\n

Proteomics Service Center (PSC<\/a>):<\/strong> Precision mass spectrometry, a driving technology in widespread use in biomedicine, and a notable strength of the Department of Biochemistry, allows for the systematic discovery and quantification of the biochemical systems active in both normal and diseased cells and tissues.\u00a0 One major goal is to define the physical and functional associations that occur normally between cellular proteins, and to determine how these macromolecular complexes are altered in disease. To this end, we recently established the Boston University Proteomics Service Center, or PSC.<\/strong>\u00a0 The PSC develops and applies powerful ‘proteome’, ‘interactome’ and ‘metabolome’ profiling techniques in a highly cooperative, holistic, multidisciplinary manner to systematically explore the molecular basis of biological processes. The PSC uses this unbiased platform to addresses important biomedical research questions to the mechanistic basis underlying human development and the causal basis of important human diseases such as cancer, metabolic, genetic, neuropathological, and viral diseases. Our technology also allows for the study of the dynamic associations of proteins with metabolites and other small molecule ligands, and the occurrence of post-translational modifications, that impact macromolecular networks in vivo.\u00a0 For more information, please visit the PSC<\/a><\/strong><\/span>.<\/span><\/p>\n

Faculty conducting research in these areas<\/span><\/h3>\n

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