- Title Research Assistant Professor
- Education D.Sc/PhD Technion – Israel Institute of Technology
- Office K606
- Email firstname.lastname@example.org
- Phone (617) 358-6515
- Area of Interest Adipose Tissue Biology, cell differentiation
I receive my D.Sc. from the Technion in Israel studying the antibacterial activity of human polymorphonuclear neutrophil and the effect of the bacterial product on this process.
During my post doctorate in the infectious department in BU I extended these studies to include the
Fungicidal activity of both human polymorphonuclear neutrophils and human platelets using candida albicans hyphae and Aspergillus fumigatus as test organisms. In both studies I concentrated mainly on reactive oxygen species.
I used these expertise when I joined Millennium Pharmaceutical as a senior scientist in the antibacterial group and developed high throughput assays to detect antibacterial in collaborations with other companies using natural products.
Coming back to BU I joined the Pilch lab and studied the effect of Caveolins/caveolae in protecting adipocytes from fatty acid-mediated lipotoxicity by sequestering fatty acids on the cytoplasmic leaflet of the plasma membrane and augmenting triglyceride formation. In Barbara Corkey’s lab I started using human adipocytes and studied the Effects of Redox Couples on ROS Production and lipid turnover and the effect of food additives such as saccharine on the production of reactive oxygen species and the function of isolated beta cells, islets and adipocytes.
In the last few years I am the Assistant Co-director of the Adipose Tissue Biology and Nutrient Metabolism (ABM) core providing human peadipocytes and adipocytes as well as banked tissues. In addition we provide consultation to new investigators in the field.
- Dance YW, MC Obenreder, AJ Seibel, T Meshulam, JW Ogony, N Lahiri, L Pacheco-Spann, DC Radisky, MD Layne, SR Farmer, CM Nelson, J Tien. Adipose Cells Induce Escape from an Engineered Human Breast Microtumor Independently of their Obesity Status. Cellular and Molecular Bioengineering (2022)
Thomas DD, Stockman MC, Yu L, Meshulam T, McCarthy AC, Ionson A, Burritt N, Deeney J, Cabral H, Corkey B, Istfan N, Apovian CM. Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study. PLoS One. 2019; 14(12):e0226200. PMID: 31869355
Jones Iv AR, Meshulam T, Oliveira MF, Burritt N, Corkey BE. Extracellular Redox Regulation of Intracellular Reactive Oxygen Generation, Mitochondrial Function and Lipid Turnover in Cultured Human Adipocytes. PLoS One. 2016; 11(10):e0164011. PMID: 27741233;
Jedrychowski MP, Liu L, Laflamme CJ, Karastergiou K, Meshulam T, Ding SY, Wu Y, Lee MJ, Gygi SP, Fried SK, Pilch PF. Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes. Mol Metab. 2015 Nov; 4(11):758-70. PMID: 26629401;
Meshulam T, Breen MR, Liu L, Parton RG, Pilch PF. Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity. J Lipid Res. 2011 Aug; 52(8):1526-32. PMID: 21652731;
Pilch PF, Meshulam T, Ding S, Liu L. Caveolae and lipid trafficking in adipocytes. Clin Lipidol. 2011; 6(1):49-58. PMID: 21625349
Simard JR, Meshulam T, Pillai BK, Kirber MT, Brunaldi K, Xu S, Pilch PF, Hamilton JA. Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity. J Lipid Res. 2010 May; 51(5):914-22. PMID: 20388923;
Meshulam T, Simard JR, Wharton J, Hamilton JA, Pilch PF. Role of caveolin-1 and cholesterol in transmembrane fatty acid movement. Biochemistry. 2006 Mar 7; 45(9):2882-93. PMID: 16503643
Joseph-McCarthy D, Parris K, Huang A, Failli A, Quagliato D, Dushin EG, Novikova E, Severina E, Tuckman M, Petersen PJ, Dean C, Fritz CC, Meshulam T, DeCenzo M, Dick L, McFadyen IJ, Somers WS, Lovering F, Gilbert AM. Use of structure-based drug design approaches to obtain novel anthranilic acid acyl carrier protein synthase inhibitors. J Med Chem. 2005 Dec 15; 48(25):7960-9. PMID: 16335920
Wharton J, Meshulam T, Vallega G, Pilch P. Dissociation of insulin receptor expression and signaling from caveolin-1 expression. J Biol Chem. 2005 Apr 8; 280(14):13483-6. PMID: 15699039
Christin L, Wysong DR, Meshulam T, Hastey R, Simons ER, Diamond RD. Human platelets damage Aspergillus fumigatus hyphae and may supplement killing by neutrophils. Infect Immun. 1998 Mar; 66(3):1181-9.PMID: 9488412;