Dr. Luebke received her doctorate in Anatomy & Neurobiology from Boston University School of Medicine. She completed a first postdoctoral fellowship in neurophysiology at Harvard Medical School and a second postdoctoral fellowship in neurophysiology at Tufts University School of Medicine and then joined the Departments Anatomy & Neurobiology and of Psychiatry at BUSM. Dr. Luebke maintains a laboratory in which whole-cell patch-clamp and intracellular filling techniques are used to examine the electrophysiological and morphological properties of neurons in in vitro slices of monkey and transgenic mouse neocortex.\u00a0 Research is focused on action potential firing patterns (and underlying ionic currents), glutamatergic and GABAergic synaptic response properties and detailed dendritic architecture.\u00a0 Data from single neurons are incorporated into computational models in collaboration with mathematicians at Mt. Sinai School of Medicine.\u00a0 In addition, collaborations are ongoing with investigators at BUSM who use molecular biological (single cell PCR and microarray) and electron microscopic (ultrastructural analysis) techniques to examine cells from which recordings are obtained. Overall goals include: 1) to examine the individual and network properties of cells in the prefrontal cortex; 2) to determine the effects of normal aging on these properties in the rhesus monkey, and; 3) to determine the effects of tau and amyloid on these properties in transgenic mouse models of Alzheimer\u2019s disease.\u00a0 Dr. Luebke\u2019s research is funded by the NIH.<\/p>\n
Dr. Luebke is a Waterhouse Professor and Chair of the Department.<\/p>\n
Lab:\u00a0<\/strong>Laboratory of Cellular Neurobiology<\/span><\/span><\/a><\/p>\n