{"id":9821,"date":"2021-09-21T11:57:21","date_gmt":"2021-09-21T15:57:21","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/anatneuro\/?page_id=9821"},"modified":"2023-12-29T19:36:07","modified_gmt":"2023-12-30T00:36:07","slug":"jp-2","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/anatneuro\/jp-2\/","title":{"rendered":"JP"},"content":{"rendered":"<\/div>\n<p><!-- ___________________Navbar___________________ --><\/p>\n<div id=\"navvy\"><\/div>\n<p><script type=\"text\/javascript\" src=\"\/anatneuro\/files\/2023\/10\/nav-10-2023.js\"><\/script><\/p>\n<p><!-- ___________________Banner___________________ --><\/p>\n<div class=\"profile-parallax\">\n<div class=\"true-nav nav-border\"><\/div>\n<div style=\"width: 40%; float: left;\" class=\"title-padding\">\n<p class=\"title-header\">Jean-Pierre Roussarie<\/p>\n<p class=\"title-header2\" style=\"text-align: left;\">Assistant Professor<\/p>\n<\/div>\n<div style=\"width: 40%; float: right;\">\n<img loading=\"lazy\" style=\"padding-top: 50px;\" width=\"320\" height=\"320\" src=\"\/anatneuro\/files\/2023\/10\/Jean-Pierre-Roussarie.png\" alt=\"\">\n<\/div>\n<\/div>\n<p><!-- ___________________Profiles___________________ --><\/p>\n<div class=\"universal-pad\">\n<div class=\"col-md-8\">\n<p>The Roussarie lab is interested in deciphering the molecular events leading to neurodegeneration in Alzheimer\u2019s disease. Like most neurodegenerative diseases, Alzheimer\u2019s affects only very specific sets of neurons in its earliest stages. These neurons are located in the entorhinal cortex, a brain region indispensable for new memory formation. Dr. Roussarie thinks that understanding the particularities of these entorhinal cortex neurons will yield novel insights into the Alzheimer\u2019s pathological processes. Eventually this will lead to the identification of new therapeutic targets to prevent neurodegeneration. In order to elucidate the properties of entorhinal neurons at single-cell resolution, the Roussarie lab uses a combination of mouse models, human postmortem tissue, novel in vitro culture protocols, and in silico modeling.<\/p>\n<p>Dr. Roussarie earned his BS from the Ecole Polytechnique (France), and his PhD from the Pasteur Institute where he studied Theiler\u2019s Virus with Dr. Michel Brahic. He completed his training at Rockefeller University where he started to work on Alzheimer\u2019s disease under the supervision of the late Nobel Prize winner Dr. Paul Greengard.<\/p>\n<p><strong><\/p>\n<p>Lab Site: <a href=\"https:\/\/www.bumc.bu.edu\/anatneuro\/roussarie-lab\/\">Roussarie Lab<\/a><\/p>\n<p><\/strong>\n<\/p>\n<\/div>\n<div class=\"col-md-4\">\n<div class=\"block-pad\">\n<div class=\"block\">\n<p style=\"font-weight: bold;\">RESEARCH:<\/p>\n<p style=\"text-align: left;\">neurodegeneration, Alzheimer\u2019s disease, genomics, selective neuronal vulnerability<\/p>\n<p style=\"font-weight: bold;\">EMAIL:<\/p>\n<p>jproussa@bu.edu<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"padding-bottom: 20px;\">\n<a href=\"http:\/\/www-staging.bumc.bu.edu\/anatneuro\/?page_id=11366&#038;preview=true\" class=\"btn\" style=\"width: 60vw;\"><br \/>\n  <span class=\"gradient-btn\">Faculty<\/span><br \/>\n<\/a>\n<\/div>\n<p><!-- ___________________Footer___________________ --><\/p>\n<link rel=\"stylesheet\" href=\"https:\/\/cdnjs.cloudflare.com\/ajax\/libs\/font-awesome\/4.7.0\/css\/font-awesome.min.css\">\n<footer class=\"siteFooter has-info\" role=\"contentinfo\">\n<div class=\"siteFooter-content\">\n<div class=\"siteFooter-info\">\n<div class=\"col-md-4\" style=\"padding-top: 20px;\">\n<p class=\"footer-header\">Contact Information:<\/p>\n<p>Department of Anatomy &amp; Neurobiology<br \/>\nChobanian &#038; Avedisian School of Medicine<br \/>\n72 East Concord St (L 1004)<br \/>\nBoston, Massachusetts 02118<br \/>\nPhone 617-358-2200<br \/>\nFax 617-358-2315<br \/>\nEmail Us: mae@bu.edu<br \/>\n<a class=\"foot\" href=\"https:\/\/maps.bu.edu\/?id=647#!ct\/\">Get Directions<\/a><\/p>\n<\/div>\n<div class=\"col-md-4\" style=\"padding-top: 20px;\">\n<a class=\"foot\" href=\"https:\/\/www.bumc.bu.edu\/anatneuro\/anatomical-gifts\/\"><\/p>\n<p class=\"footer-header\">Anatomical Gift Program:<\/p>\n<p><\/a><\/p>\n<p>Phone 617-358-2105<br \/>\nEmail the program: leeanne@bu.edu<\/p>\n<\/div>\n<div class=\"col-md-4\" style=\"padding-top: 40px;\">\n<p class=\"footer-header\" align=\"center\">\n<nav class=\"social-buttons\">\n<ul class=\"text\">\n<li><a class=\"social-button\" href=\"#\"><i class=\"fa fa-facebook fa-2x\"><\/i><\/a><\/li>\n<li><a class=\"social-button\" href=\"https:\/\/twitter.com\/BUAnatNeuro \"><i class=\"fa fa-twitter fa-2x\"><\/i><\/a><\/li>\n<li><a class=\"social-button\" href=\"#\"><i class=\"fa fa-linkedin fa-2x\"><\/i><\/a><\/li>\n<li><a class=\"social-button\" href=\"https:\/\/www.instagram.com\/buanatneuro\/\"><i class=\"fa fa-instagram fa-2x\"><\/i><\/a><\/li>\n<\/ul>\n<\/nav>\n<\/div>\n<\/div>\n<\/div>\n<\/footer>\n<style>\n<p>article.post-12356 {\n   display: none;\n}<\/p>\n<p>\/* ----------------Blocks---------------- *\/<\/p>\n<p>.block {\n    background-color: #ffffff;\n    padding: 15px;\n    margin: auto;\n    height: 300px;\n    width: 300px;\n    border-radius: 3px;\n    align-items: center;\n    z-index: 2;\n    box-shadow: -50px 0 100px -50px #808080, 50px 0 100px -50px #808080;\n}<\/p>\n<p>.block-pad {\n    margin-top: 20px;\n    margin-bottom: 20px;\n}<\/p>\n<p>@media only screen and (min-width: 760px) {\n\t.block {\n\t\twidth: 300px;\n             height: 300px;\n\t}\n}<\/p>\n<p>.block h1 {\n    padding-bottom: 5px;\n    font-size: 24px;\n    text-align: center;\n}<\/p>\n<p>\/* ----------------Profile---------------- *\/<\/p>\n<p>.side-info {\n    background-color: #ffffff;\n}<\/p>\n<p>.universal-pad {\n    margin: 25px;\n    margin-left: 10vw;\n    margin-right: 10vw;\n}<\/p>\n<p>.firstinfo{\n  display: flex;\n  justify-content: center;\n  align-items: center;\n}<\/p>\n<p>.content1 {\n  position: relative;\n  animation: animatop 0.9s cubic-bezier(0.425, 1.14, 0.47, 1.125) forwards;\n  margin-left: 12vw;\n  margin-top: 10px;\n  margin-bottom: 10px;\n}<\/p>\n<p>.card {\n  width: 70vw;\n  min-height: 100px;\n  padding: 20px;\n  border-radius: 3px;\n  background-color: white;\n  box-shadow: 0px 10px 20px rgba(0, 0, 0, 0.2);\n  position: relative;\n  overflow: hidden;\n}\n.card:after {<\/p>\n<p>}<\/p>\n<p>.firstinfo {\n  flex-direction: row;\n  z-index: 2;\n  position: relative;\n}\n.firstinfo img {\n  display: none;\n}\n.firstinfo .profileinfo {\n  padding: 0px 20px;\n}\n.firstinfo .profileinfo h1 {\n  font-size: 35px;\n}\n.firstinfo .profileinfo h3 {\n  font-size: 20px;\n  color: #262262;\n  font-style: italic;\n}\n.firstinfo .profileinfo p.bio {\n  padding: 10px 0px;\n  color: #5A5A5A;\n  line-height: 1.2;\n  font-style: initial;\n}<\/p>\n<p>@keyframes animatop {\n  0% {\n    opacity: 0;\n    bottom: -500px;\n  }\n  100% {\n    opacity: 1;\n    bottom: 0px;\n  }\n}\n@keyframes animainfos {\n  0% {\n    bottom: 10px;\n  }\n  100% {\n    bottom: -42px;\n  }\n}\n@keyframes rotatemagic {\n  0% {\n    opacity: 0;\n    transform: rotate(0deg);\n    top: -24px;\n    left: -253px;\n  }\n  100% {\n    transform: rotate(-30deg);\n    top: -24px;\n    left: -78px;\n  }\n}<\/p>\n<p>@media only screen and (min-width: 900px) {\n.card:after {\n  content: \"\";\n  display: block;\n  width: 190px;\n  height: 300px;\n  background: #262262;\n  position: absolute;\n  animation: rotatemagic 0.75s cubic-bezier(0.425, 1.04, 0.47, 1.105) 1s both;\n}<\/p>\n<p>.firstinfo img {\n  border-radius: 50%;\n  width: 120px;\n  height: 120px;\ndisplay: block;\n}<\/p>\n<p>}\n\/* ----------------Animated Button---------------- *\/<\/p>\n<p>.gradient-btn {\n  \/* Fallback: Set a background color. *\/\n  background-color: #262262;<\/p>\n<p>  \/* Create the gradient. *\/\n  background-image: linear-gradient(\n    45deg,\n    #ffffff 50%,\n    #262262 50%\n  );<\/p>\n<p>  \/* Set the background size and repeat properties. *\/\n  background-size: 270%;\n  background-repeat: repeat;\n  background-position: top right;<\/p>\n<p>  \/* Use the text as a mask for the background. *\/\n  \/* This will show the gradient as a text color rather than element bg. *\/\n  -webkit-background-clip: text;\n  -webkit-text-fill-color: transparent; \n  -moz-background-clip: text;\n  -moz-text-fill-color: transparent;<\/p>\n<p>  animation: button-animation 0.65s 0.15s ease-out forwards;\n}<\/p>\n<p>a.btn:hover, a.btn:hover span{\n    animation: button-animation-rev 0.65s ease-out forwards;\n}<\/p>\n<p>a.btn:hover {\n  box-shadow: 3px 2px 10px 1px rgba(0,0,0,0.15);\n  transition: 0.5s;\n}<\/p>\n<p>@keyframes button-animation {\n  0% {\n    background-position: top right;\n  }\n  100% {\n    background-position: top left;\n  }\n}<\/p>\n<p>@keyframes button-animation-rev {\n  0% {\n    background-position: top left;\n  }\n  100% {\n    background-position: top right;\n  }\n}<\/p>\n<p>a.btn {\n  margin-top: 1em;\n  margin-left: auto;\n  margin-right: auto;\n  background-image: linear-gradient(45deg, #262262 50%, #ffffff 50%);\n  background-size: 270%;\n  background-repeat: repeat;\n  background-position: top right;\n  animation: button-animation 0.65s 0.15s ease-out forwards;\n  display: table;\n  border-radius: 0.5em;\n  text-decoration: none;\n  box-shadow: 7px 4px 20px 1px rgba(0,0,0,0.15);\n  padding: 1.5em 0;\n  cursor: pointer;\n  width: 80%;\n  text-align: center;\n}<\/p>\n<p>a.btn span {\n  font-family: 'Open Sans', sans-serif;\n  font-weight: bold;\n  font-size: 2em;\n  text-align: center;\n  margin-bottom: 0;\n  margin-bottom: -0.25em;\n  width: 100%;\n  padding: 0 1.5em;\n}<\/p>\n<p>* {\n  margin: 0;\n  box-sizing: border-box;\n}<\/p>\n<\/style>\n","protected":false},"excerpt":{"rendered":"<p>Jean-Pierre Roussarie Assistant Professor The Roussarie lab is interested in deciphering the molecular events leading to neurodegeneration in Alzheimer\u2019s disease. Like most neurodegenerative diseases, Alzheimer\u2019s affects only very specific sets of neurons in its earliest stages. These neurons are located in the entorhinal cortex, a brain region indispensable for new memory formation. Dr. Roussarie thinks [&hellip;]<\/p>\n","protected":false},"author":18550,"featured_media":0,"parent":0,"menu_order":84,"comment_status":"closed","ping_status":"closed","template":"page-templates\/no-sidebars.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/9821"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/users\/18550"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/comments?post=9821"}],"version-history":[{"count":11,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/9821\/revisions"}],"predecessor-version":[{"id":12192,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/9821\/revisions\/12192"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/media?parent=9821"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}