{"id":9325,"date":"2021-09-20T20:31:15","date_gmt":"2021-09-21T00:31:15","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/anatneuro\/?page_id=9325"},"modified":"2026-06-25T08:42:10","modified_gmt":"2026-06-25T12:42:10","slug":"tara-moore","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/anatneuro\/tara-moore\/","title":{"rendered":"Tara Moore"},"content":{"rendered":"<\/div>\n<p><!-- ___________________Navbar___________________ --><\/p>\n<div id=\"navvy\"><\/div>\n<p><script type=\"text\/javascript\" src=\"\/anatneuro\/files\/2022\/01\/nav.js\"><\/script><\/p>\n<div class=\"mobile-title\">\n<p class=\"mobile-header\">Tara Moore<\/p>\n<\/div>\n<p><!-- ___________________Banner___________________ --><\/p>\n<div class=\"profile-parallax\">\n<div class=\"true-nav nav-border\"><\/div>\n<div style=\"width: 40%; float: left;\" class=\"title-padding\">\n<p class=\"title-header\">Tara Moore<\/p>\n<p class=\"title-header2\" style=\"text-align: left;\">Professor; Associate Dean for Research, ad interim<\/p>\n<\/div>\n<div style=\"width: 40%; float: right;\">\n<img loading=\"lazy\" style=\"padding-top: 50px;\" width=\"320\" height=\"320\" src=\"\/anatneuro\/files\/2026\/06\/Moore-hi-res-headshot.png\" alt=\"\">\n<\/div>\n<\/div>\n<p><!-- ___________________Profiles___________________ --><\/p>\n<div class=\"universal-pad\">\n<div class=\"col-md-8\">\n<p>Dr. Moore received her B.A. in psychology from the University of Calgary and her<br \/>\ndoctorate in Anatomy and Neurobiology from this department in 2000. She is<br \/>\ncurrently the Director of the Laboratory of Interventions for Cortical Injury and<br \/>\nCognitive Decline.<\/p>\n<p>Dr. Moore\u2019s primary research focus is the assessment of cognitive and motor function<br \/>\nimpairments in our rhesus monkey models of cortical injury and aging and the<br \/>\nunderlying neurobiological basis for these impairments. In both models, she assessing<br \/>\nthe efficacy of an exciting new therapeutic, mesenchymal stromal cell derived<br \/>\nextracellular vesicles (MSC-EVs), to reverse deficits in cognitive and motor function by<br \/>\ndecreasing neuroinflammation and myelin pathology.<\/p>\n<p>Her model of cortical injury involves training monkeys on our tasks of fine motor function<br \/>\nof the hand, neurosurgical lesion production in primary motor cortex, assessment of<br \/>\nrecovery of fine motor function and post-perfusion analysis of blood, CSF and brain and<br \/>\nspinal cord tissue. This model is used to establish the rate and degree of recovery of<br \/>\nfunction following cortical injury in the aged brain and to investigate the neurobiological<br \/>\nbasis for recovery. Further, she is assessing the efficacy of MSC-EVs as a restorative<br \/>\ntreatment to facilitate recovery of function following cortical injury. This work is being<br \/>\nconducted in collaboration with researchers at the Henry Ford Health System and the<br \/>\nUniversity of Buffalo. To date, she has demonstrated that administration of MSC-EVs,<br \/>\nfacilitates a complete recovery of fine motor function in the first 3-4 weeks after injury.<br \/>\nFurther, MSC-EVs reduce injury-induced neuroinflammation, synapse loss, oligodendrocyte damage and myelination deficits. Finally, a<br \/>\nrecent collaborative proteomic study<br \/>\nshowed that proteins from MSC-EVs are involved in signaling<br \/>\npathways related to complement signaling, protein dynamics, and extracellular matrix stabilization, that may be involved in ameliorating injury-related neurodegeneration, inflammation and plasticity.<\/p>\n<p>In her aging study, she is administering MSC-EVs to aged monkeys to determine their efficacy in slowing or reversing age-related cognitive decline. After a period of 18 months of treatment, treated monkeys show significant improvement in spatial working memory. Further, treated animals showed increased white matter structural integrity on MRI and a preservation of inter-network functional connectivity as measured by resting-state functional MRI. Currently studies involve assessing treatment related changes in blood and CSF biomarkers of inflammation and oxidative damage and changes in neuroinflammation and myelin pathology in brain tissue.<\/p>\n<p>Finally, she is in the early stages of developing a rhesus monkey model of hypertension<br \/>\n(HT), using the well-established \u201cone kidney-one clip\u201d model of hypertension used in<br \/>\nrodents. With this model, she will establish the effect of HT of cognitive function in<br \/>\nmiddle-aged rhesus monkey and how HT alters the inflammation and myelin integrity in<br \/>\nthe aged brain.<\/p>\n<p>Dr. Moore is the Associate Dean for Research, ad interim and the Director of the graduate program MS in Forensic Anthropology.  She teaches Professional Skills and Human Anatomy and Osteology in the Forensic Anthropology program and Neurobiology of Aging in the department of Anatomy and Neurobiology. Dr. Moore is also the Vice-Chair of the Institutional Animal Use and Care Committee..\n<\/p>\n<p><strong>Lab:&nbsp;<\/strong><a href=\"https:\/\/www.bumc.bu.edu\/anatneuro\/moore-lab\/\" target=\"_self\" rel=\"noopener noreferrer\"><span class=\"standard\"><span>Laboratory of Interventions for Cortical Injury and Cognitive Decline<\/span><\/span><\/a><\/p>\n<p><strong>CV:<\/strong><span>&nbsp;<\/span><a href=\"\/anatneuro\/files\/2018\/11\/CV_MOORE_11.13.2018.pdf\">Tara Moore, Ph.D.\u2013 CV<\/a><\/p>\n<\/div>\n<div class=\"col-md-4\">\n<div class=\"block-pad\">\n<div class=\"block\">\n<p style=\"font-weight: bold;\">RESEARCH:<\/p>\n<p style=\"text-align: left;\">cortical injury, normal aging, primate behavior, extra-cellular vesicles<\/p>\n<p style=\"font-weight: bold;\">OFFICE:<\/p>\n<p>W-735, CAMED<\/p>\n<p style=\"font-weight: bold;\">EMAIL:<\/p>\n<p>tlmoore@bu.edu<\/p>\n<p style=\"font-weight: bold;\">PHONE:<\/p>\n<p>617-358-8278<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"padding-bottom: 20px;\">\n<a href=\"https:\/\/www.bumc.bu.edu\/anatneuro\/faculty\/\" class=\"btn\" style=\"width: 60vw;\"><br \/>\n  <span class=\"gradient-btn\">Faculty<\/span><br \/>\n<\/a>\n<\/div>\n<style>\n<p>article.post-12399 {\n   display: none;\n}<\/p>\n<p>\/* ----------------Blocks---------------- *\/<\/p>\n<p>.block {\n    background-color: #ffffff;\n    padding: 15px;\n    margin: auto;\n    height: 550px;\n    width: 300px;\n    border-radius: 3px;\n    align-items: center;\n    z-index: 2;\n    box-shadow: -50px 0 100px -50px #808080, 50px 0 100px -50px #808080;\n}<\/p>\n<p>.block-pad {\n    margin-top: 20px;\n    margin-bottom: 20px;\n}<\/p>\n<p>@media only screen and (min-width: 760px) {\n\t.block {\n\t\twidth: 300px;\n             height: 550px;\n\t}\n}<\/p>\n<p>.block h1 {\n    padding-bottom: 5px;\n    font-size: 24px;\n    text-align: center;\n}<\/p>\n<p>\/* ----------------Profile---------------- *\/<\/p>\n<p>.side-info {\n    background-color: #ffffff;\n}<\/p>\n<p>.universal-pad {\n    margin: 25px;\n    margin-left: 10vw;\n    margin-right: 10vw;\n}<\/p>\n<p>.firstinfo{\n  display: flex;\n  justify-content: center;\n  align-items: center;\n}<\/p>\n<p>.content1 {\n  position: relative;\n  animation: animatop 0.9s cubic-bezier(0.425, 1.14, 0.47, 1.125) forwards;\n  margin-left: 12vw;\n  margin-top: 10px;\n  margin-bottom: 10px;\n}<\/p>\n<p>.card {\n  width: 70vw;\n  min-height: 100px;\n  padding: 20px;\n  border-radius: 3px;\n  background-color: white;\n  box-shadow: 0px 10px 20px rgba(0, 0, 0, 0.2);\n  position: relative;\n  overflow: hidden;\n}\n.card:after {<\/p>\n<p>}<\/p>\n<p>.firstinfo {\n  flex-direction: row;\n  z-index: 2;\n  position: relative;\n}\n.firstinfo img {\n  display: none;\n}\n.firstinfo .profileinfo {\n  padding: 0px 20px;\n}\n.firstinfo .profileinfo h1 {\n  font-size: 35px;\n}\n.firstinfo .profileinfo h3 {\n  font-size: 20px;\n  color: #262262;\n  font-style: italic;\n}\n.firstinfo .profileinfo p.bio {\n  padding: 10px 0px;\n  color: #5A5A5A;\n  line-height: 1.2;\n  font-style: initial;\n}<\/p>\n<p>@keyframes animatop {\n  0% {\n    opacity: 0;\n    bottom: -500px;\n  }\n  100% {\n    opacity: 1;\n    bottom: 0px;\n  }\n}\n@keyframes animainfos {\n  0% {\n    bottom: 10px;\n  }\n  100% {\n    bottom: -42px;\n  }\n}\n@keyframes rotatemagic {\n  0% {\n    opacity: 0;\n    transform: rotate(0deg);\n    top: -24px;\n    left: -253px;\n  }\n  100% {\n    transform: rotate(-30deg);\n    top: -24px;\n    left: -78px;\n  }\n}<\/p>\n<p>@media only screen and (min-width: 900px) {\n.card:after {\n  content: \"\";\n  display: block;\n  width: 190px;\n  height: 300px;\n  background: #262262;\n  position: absolute;\n  animation: rotatemagic 0.75s cubic-bezier(0.425, 1.04, 0.47, 1.105) 1s both;\n}<\/p>\n<p>.firstinfo img {\n  border-radius: 50%;\n  width: 120px;\n  height: 120px;\ndisplay: block;\n}<\/p>\n<p>}\n\/* ----------------Animated Button---------------- *\/<\/p>\n<p>.gradient-btn {\n  \/* Fallback: Set a background color. *\/\n  background-color: #262262;<\/p>\n<p>  \/* Create the gradient. *\/\n  background-image: linear-gradient(\n    45deg,\n    #ffffff 50%,\n    #262262 50%\n  );<\/p>\n<p>  \/* Set the background size and repeat properties. *\/\n  background-size: 270%;\n  background-repeat: repeat;\n  background-position: top right;<\/p>\n<p>  \/* Use the text as a mask for the background. *\/\n  \/* This will show the gradient as a text color rather than element bg. *\/\n  -webkit-background-clip: text;\n  -webkit-text-fill-color: transparent; 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Associate Dean for Research, ad interim Dr. Moore received her B.A. in psychology from the University of Calgary and her doctorate in Anatomy and Neurobiology from this department in 2000. She is currently the Director of the Laboratory of Interventions for Cortical Injury and Cognitive Decline. Dr. Moore\u2019s primary research [&hellip;]<\/p>\n","protected":false},"author":18550,"featured_media":0,"parent":0,"menu_order":64,"comment_status":"closed","ping_status":"closed","template":"page-templates\/no-sidebars.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/9325"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/users\/18550"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/comments?post=9325"}],"version-history":[{"count":16,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/9325\/revisions"}],"predecessor-version":[{"id":12813,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/9325\/revisions\/12813"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/media?parent=9325"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}