{"id":9305,"date":"2021-09-20T20:30:40","date_gmt":"2021-09-21T00:30:40","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/anatneuro\/?page_id=9305"},"modified":"2025-08-26T08:58:04","modified_gmt":"2025-08-26T12:58:04","slug":"moore-lab","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/anatneuro\/moore-lab\/","title":{"rendered":"Laboratory of Interventions for Cortical Injury &#038; Cognitive Decline"},"content":{"rendered":"<\/div>\n<p><!-- ___________________Navbar___________________ --><\/p>\n<div id=\"navvy\"><\/div>\n<p><script type=\"text\/javascript\" src=\"\/anatneuro\/files\/2025\/05\/nav-5-2025.js\"><\/script><\/p>\n<div class=\"mobile-title\">\n<p class=\"mobile-header\">Interventions for Cortical Injury &#038; Cognitive Decline<\/p>\n<\/div>\n<p><!-- ___________________Banner___________________ --><\/p>\n<div class=\"brain-health-parallax\">\n<div class=\"true-nav nav-border\"><\/div>\n<div class=\"title-padding\">\n<p class=\"title-header\" style=\"text-align: left;\">Interventions for Cortical Injury &#038; Cognitive Decline<\/p>\n<\/div>\n<\/div>\n<p><!-- ___________________Main___________________ --><\/p>\n<div class=\"universal-pad\">\n<div class=\"center\">\n<h3 style=\"text-align: left;\">Lab Director: <a title=\"Tara Moore, Ph.D.\" href=\"https:\/\/www.bumc.bu.edu\/anatneuro\/profile\/moore\/\">Tara Moore Ph.D.<\/a><\/h3>\n<p>Our laboratory for Interventions for Cortical Injury and Cognitive Decline focuses its research<br \/>\nefforts on studying cognitive abilities and motor impairments across the lifespan and following<br \/>\ncortical injury in the rhesus monkey. Specifically, we examine age-related changes in cognitive<br \/>\nand motor functions and assess the response of the aging brain to injury. In addition, we study<br \/>\nthe efficacy of various therapeutic interventions to slow or reverse age-related changes in<br \/>\ncognition and stimulate recovery of function following cortical injury.<\/p>\n<p>We are currently assessing the efficacy of a novel therapeutic interventions, mesenchymal<br \/>\nstromal cell derived extracellular vesicles to enhance recovery of fine motor function of the<br \/>\nhand, reduce inflammation and stimulate plasticity and cortical reorganization following<br \/>\ncortical injury and for reversing age-associated inflammation, myelin degeneration and<br \/>\ncognitive decline. This work is completed with our collaborators at the Henry Ford Health<br \/>\nSystem in Detroit, MI. Our research is support by grants from the National Institute of Aging<br \/>\nand the National Institute of Neurological Disease and Stroke.\n<\/p>\n<p><img src=\"\/anatneuro\/files\/2023\/10\/Moore-Website-pic.jpg\" alt=\"\" style=\"margin: auto; display: block;\"><\/p>\n<h3>Laboratory News and Events:<\/h3>\n<p>&#8211; Our undergraduate student, Rutu Tatke, presented the research she completed in our laboratory as part of her UROP award. Rutu has been working on our study investigating the effects of mesenchymal stromal cell derived extra-cellular vesicles to reverse the inflammatory response after cortical injury. Congratulations Rutu!<\/p>\n<p><img loading=\"lazy\" src=\"\/anatneuro\/files\/2023\/10\/unnamed-scaled.jpg\" alt=\"\" width=\"15%\" height=\"15%\" style=\"margin: auto; display: block;\"><\/p>\n<\/div>\n<div class=\"center\">\n<h2>Faculty<\/h2>\n<div>\n<img loading=\"lazy\" src=\"\/anatneuro\/files\/2018\/09\/Moore.png\" alt=\"Picture of Dr Tara Moore\" width=\"100\" height=\"100\"><\/p>\n<h4><a href=\"https:\/\/www.bumc.bu.edu\/anatneuro\/profile\/moore\/\">Tara L. Moore, Ph.D.<\/a><\/h4>\n<p>Dr. Moore\u2019s research focus is the assessment of cognitive and motor function<br \/>\nimpairments in our rhesus monkey models of cortical injury and aging and the<br \/>\nunderlying neurobiological basis for these impairments. In both models, we are also<br \/>\nassessing the efficacy of an exciting new therapeutic, mesenchymal stromal cell derived<br \/>\nextracellular vesicles (MSC-EVs), to reverse deficits in cognitive and motor function by<br \/>\ndecreasing neuroinflammation and myelin pathology.<\/p>\n<p>Our model of cortical injury involves training monkeys on our tasks of fine motor function<br \/>\nof the hand, neurosurgical lesion production in primary motor cortex, assessment of<br \/>\nrecovery of fine motor function and post-perfusion analysis of blood, CSF and brain and<br \/>\nspinal cord tissue. This model is used to establish the rate and degree of recovery of<br \/>\nfunction following cortical injury in the aged brain and to investigate the neurobiological<br \/>\nbasis for recovery. Further, we are assessing the efficacy of MSC-EVs as a restorative<br \/>\ntreatment to facilitate recovery of function following cortical injury. This work is being<br \/>\nconducted in collaboration with researchers at the Henry Ford Health System and the<br \/>\nUniversity of Buffalo. To date, we have demonstrated that administration of MSC-EVs,<br \/>\nfacilitates a complete recovery of fine motor function in the first 3-4 weeks after injury.<br \/>\nFurther, MSC-EVs reduce injury-induced microglial neuroinflammation, neuronal<br \/>\nexcitotoxicity, synapse loss, oligodendrocyte damage and myelination deficits. Finally, a<br \/>\nrecent collaborative proteomic study using a GO analysis of Biological Processes<br \/>\nshowed that proteins from MSC-EVs are highly specific and involved in signaling<br \/>\npathways for cell-cell adhesion, cell proliferation, extracellular matrix organization,<br \/>\nMAPK cascade, Wnt signaling, and small GTPase mediated signal transduction, some<br \/>\nof which, play important neuritogenic and synaptogenic roles that could be involved in<br \/>\nameliorating injury-related neurodegeneration and hyperexcitability.<\/p>\n<p>In our aging study, we are administering MSC-EVs to aged monkeys following extensive<br \/>\ncognitive assessment. After a period of 18 months of treatment, we re-assess the<br \/>\ncognitive performance of the monkeys to determine whether the MSC-EVs have slowed or reversed age-related cognitive decline. We also acquire longitudinal MRIs and blood and CSF samples from these monkeys to quantify various biomarkers of inflammation and oxidative damage. Following completion of treatment and cognitive testing, brains<br \/>\nwill be harvested and analyze for treatment related changes in neuroinflammation and<br \/>\nmyelin pathology.<\/p>\n<p>Finally, we are in the early stages of developing a rhesus monkey model of<br \/>\nhypertension (HT), using the well-established \u201cone kidney-one clip\u201d model of<br \/>\nhypertension used in rodents. With this model, we will establish the effect of HT of<br \/>\ncognitive function in middle-aged rhesus monkey and how HT alters the inflammation<br \/>\nand myelin integrity in the aged brain.<\/p>\n<\/div>\n<div>\n<img loading=\"lazy\" src=\"\/anatneuro\/files\/2018\/09\/Rosene.png\" alt=\"Picture of Dr Rosne\" width=\"100\" height=\"100\"><\/p>\n<h4><a href=\"https:\/\/www.bumc.bu.edu\/anatneuro\/profile\/rosene\/\">Douglas L. Rosene, Ph.D.<\/a><\/h4>\n<p>Dr. Rosene\u2019s research interests focus on (1) the effect of age on brain integrity, including white matter, neurotransmitter systems and neural transmission in a primate model of normal human aging (2) the interaction of the prefrontal cortices with the medial temporal lobe limbic system 3) the effect of prenatal malnutrition on brain integrity in a rodent model 4) modeling methods to characterize age-related changes in microcolumns in the cerebral cortex and 5) the recovery of fine motor function and re- organization of the motor cortex following cortical injury in the rhesus monkey.<\/p>\n<\/div>\n<div>\n<img loading=\"lazy\" src=\"\/anatneuro\/files\/2018\/09\/Medalla.png\" alt=\"Picture of Dr Medalla\" width=\"100\" height=\"100\"><\/p>\n<h4><a href=\"https:\/\/www.bumc.bu.edu\/anatneuro\/profile\/medalla\/\">Maya Medalla, Ph.D.<\/a><\/h4>\n<p>Dr. Medalla research focuses on deciphering the pathway-specific structural and physiological properties of distinct cortical circuits in both primate and rodent animal models. She combines cellular&nbsp;in vitro&nbsp;electrophysiological methods with multi-scale anatomic techniques to understand the biophysical and synaptic properties of neurons within functionally-related cortical networks. Her expertise includes patch-clamp recording, pathway tract-tracing, multiple immunohistochemical labeling techniques for light and electron microscopy (EM), 3D serial EM, and confocal microscopy. The major goal of her work is to understand how distinct limbic, sensory and motor networks interact and are controlled by the PFC \u2013 the central executive of the brain. Her current focus is on the medial prefrontal anterior cingulate cortex (ACC) in rhesus monkeys, an area important for attention, emotions and context-to-action transformations, and is selectively disrupted in many affective disorders such as depression and anxiety disorders. In her ongoing collaboration with Dr. Moore, she specifically investigates changes in markers of synaptic plasticity, and the anatomical and electrophysiological properties of motor cortical neurons and circuits after cortical injury.<\/p>\n<\/div>\n<div>\n<img loading=\"lazy\" src=\"\/anatneuro\/files\/2018\/09\/Pessina.png\" alt=\"Picture of Dr Pessina\" width=\"100\" height=\"100\"><\/p>\n<h4><a href=\"https:\/\/www.bumc.bu.edu\/anatneuro\/profile\/monica-pessina\/\">Monica Pessina, Ph.D.<\/a><\/h4>\n<p>Dr. Pessina received her B.S. in Occupational Therapy from Boston University, followed by a Master\u2019s in Education from Northeastern University and a Ph.D. in Anatomy and Neurobiology from Chobanian &#038; Avedisian School of Medicine. Prior to assuming a full-time academic appointment at CAMED, she gained extensive experience at Massachusetts General Hospital in the field of upper extremity rehabilitation following orthopedic, neurological and burn injuries. In addition, she is the former Director of Rehabilitation at Shriners Burns Institute and she continues to work as an educator in the field of burn rehabilitation both nationally and internationally. Dr. Pessina currently teaches Gross Anatomy and Microscopic Anatomy at BU School of Medicine and BU Goldman School of Dental Medicine where she serves in various roles including Course Director, Section Leader, Lecturer and Laboratory Instructor. As an extension of her clinical interests, Dr. Pessina is involved in assessing the nature of recovery of fine motor function of the hand in our NHP model of cortical injury. She has adapted human occupational therapy scales for recovery of grasp for use with NHPs.<\/p>\n<\/div>\n<h2>Current Doctoral Students<\/h2>\n<div>\n<img loading=\"lazy\" src=\"\/anatneuro\/files\/2023\/08\/Ryan-McCann.png\" alt=\"\" width=\"100\" height=\"100\"><\/p>\n<h4>Ryan McCann<\/h4>\n<p>Ryan is a PhD student in the Graduate Program for Neuroscience. He graduated from Emory University with a degree in Neuroscience and Behavioral Biology in 2020 where his research involved tau rodents. Ryan joined Dr. Moore\u2019s lab in 2021 and began working on the cortical injury project using the MSC-EV treatment. His work focuses on the effect of MSC-EVs on neuroinflammation and damage in the injured brain.<\/p>\n<\/div>\n<div>\n<img loading=\"lazy\" src=\"\/anatneuro\/files\/2023\/08\/angela-profile.png\" alt=\"\" width=\"100\" height=\"100\"><\/p>\n<h4>Angela Capriglione<\/h4>\n<p>Angela is a 3rd year Ph.D. student in the Department of Anatomy &#038; Neurobiology. She received her B.S. in Neurobiology from Simmons University. She is currently researching the effects of extracellular vesicles derived from mesenchymal stem cells on neuronal properties in the prefrontal cortex of aged rhesus monkeys.<\/p>\n<\/div>\n<div>\n<img loading=\"lazy\" src=\"\/anatneuro\/files\/2023\/08\/Mackie.png\" alt=\"\" width=\"100\" height=\"100\"><\/p>\n<h4>Evan Mackie<\/h4>\n<p>Evan received his BA in Neuroscience from Boston University in 2022 and is currently a PhD student in the department of Anatomy and Neurobiology. He initially joined the Moore Laboratory in 2019 as an undergraduate, contributing to projects investigating the recovery of fine motor function after cortical injury. His current graduate research focuses on evaluating the efficacy of Extracellular Vesicles derived from Mesenchymal Stromal Cells (MSC-EVs) as a therapeutic for age-related cognitive decline and neuropathology in rhesus monkeys. Beyond working behaviorally and clinically with NHPs, Evan&#8217;s research interests include studying the inflammatory response, white matter pathology, and glial cell populations during normal aging.<\/p>\n<\/div>\n<div>\n<img loading=\"lazy\" src=\"\/anatneuro\/files\/2025\/08\/headshot.png\" alt=\"\" width=\"100\" height=\"100\"><\/p>\n<h4>Christina Tsillas<\/h4>\n<p>Christina received her B.S. in Biochemistry and Psychological Science from Worcester Polytechnic Institute in 2023 before starting her Ph.D. in the Department of Anatomy and Neurobiology. She joined the Moore Laboratory in 2024 to pursue her interest in studying neuroinflammation in the context of aging and injury. Her current research focuses on evaluating the effect of systemic MSC-EVs treatment on microglial dynamics and resulting modulation of neuroinflammation following cortical injury in the rhesus macaque.<\/p>\n<\/div>\n<h2>Research Associates\/Coordinators\/Managers<\/h2>\n<div>\n<img loading=\"lazy\" src=\"\/anatneuro\/files\/2023\/08\/bryce-profile.png\" alt=\"\" width=\"100\" height=\"100\"><\/p>\n<h4>Bryce Connor<\/h4>\n<p>Bryce graduated from the University of Massachusetts, Amherst in 2021. He is now a research technician in our laboratory and has an interest in aging research. Bryce has previously worked with non-human primates as an undergraduate at UMass Amherst. His interests include Alzheimer&#8217;s research and promoting diversity and representation within STEM fields.<\/p>\n<\/div>\n<div>\n<img loading=\"lazy\" src=\"\/anatneuro\/files\/2023\/08\/christine-profile.png\" alt=\"\" width=\"100\" height=\"100\"><\/p>\n<h4>Christine Rutledge<\/h4>\n<p>Christine graduated from Johnson &#038; Wales University in Providence, RI.  After working at a zoological facility for 8 years with a variety of domestic and exotic animals, she joined our laboratory in 2022 with an interest in behavioral testing. She currently tests rhesus monkeys on cognitive and motor tasks, and coordinates and performs clinical procedures for study subjects.<\/p>\n<\/div>\n<div>\n<img loading=\"lazy\" src=\"\/anatneuro\/files\/2023\/08\/maya-profile.png\" alt=\"\" width=\"100\" height=\"100\"><\/p>\n<h4>Maya Alibrio<\/h4>\n<p>Maya graduated from The University of Rhode Island with a BA in anthropology and her MS in forensic anthropology from Boston University Chobanian and Avedisian School of Medicine. Her responsibilities in the lab include testing NHPs in both cognitive and motor tests as well as performing clinical procedures. Maya hopes to one day follow her passion of forensic anthropology by working in medicolegal death investigation or museum skeletal collections.<\/p>\n<\/div>\n<h2>Graduates<\/h2>\n<div>\n<h4>Kayla M. Nist, MS<\/h4>\n<p>Kayla earned her Bachelor of Arts in Psychology from The Ohio State University in 2018 and in 2020, she earned her Master of Science in Anatomy &#038; Neurobiology at Chobanian &#038; Avedisian School of Medicine. Her MS thesis work focused the role of the blood brain barrier in age-dependent hypertension. Currently, Kayla is completing her PhD under the mentorship of Dr. Moore and Dr. Richard Wainford in projects addressing aging and hypertension. In Dr. Moore\u2019s laboratory, her project focuses on identifying the blood pressure phenotype in the aging rhesus monkey and the role of hypertension in the development and progression of cognitive decline using a 2-kidney 1-clip rhesus monkey model of renovascular hypertension.<\/p>\n<\/div>\n<div>\n<img loading=\"lazy\" src=\"\/anatneuro\/files\/2023\/02\/KarenBottenfield-scaled-e1675399865461.jpg\" alt=\"\" width=\"100\" height=\"100\"><\/p>\n<h4>Karen Bottenfield<\/h4>\n<p>Karen graduated with her PhD from the department in July 2022. She received her A.A. from Spokane Falls Community College, B.A. in Anthropology from Eastern Washington University, and her M.S. in Forensic Anthropology from Chobanian &#038; Avedisian School of Medicine. Karen has been using our rhesus monkey model of cortical injury to evaluate Glial Growth Factor 2 (an isoform of neurgulin-1) as a treatment for recovery of fine motor function. This project also involved immunohistochemical analyses of the brain tissue for markers of inflammation and plasticity. Karen also optimized a novel method to quantify newly synthesized myelin in the rhesus monkey brain that will be used to investigate myelin maintenance and plasticity in our normal aging and cortical injury models. Karen is currently the Senior Academic Program Manager, Oral Health Sciences Master\u2019s Program at Boston University Chobanian &#038; Avedisian School of Medicine.<\/p>\n<\/div>\n<div>\n<img loading=\"lazy\" src=\"\/anatneuro\/files\/2019\/06\/ajay-uprety-copy.png\" alt=\"\" width=\"100\" height=\"100\"><\/p>\n<h4>Ajay Uprety<\/h4>\n<p>Ajay worked on a project in which we examined the potential benefits of Curcumin supplementation in the aging monkey. Over a 3 year period, monkeys were given a daily oral supplement of either curcumin or vehicle control while completing testing on a battery of assessments.  Ajay&#8217;s research interests include understanding the effects of Curcumin on Object Discrimination and Reversal learning, microglia morphology and function, neurogenesis and systemic inflammation. Ajay defended his pre-doctoral work in the summer of 2021 and is currently a post-doctoral candidate at the George Washington University.<\/p>\n<\/div>\n<div>\n<img loading=\"lazy\" src=\"\/anatneuro\/files\/2019\/06\/veronicago-copy.png\" alt=\"\" width=\"100\" height=\"100\"><\/p>\n<h4>Veronica Go<\/h4>\n<p>Veronica was a student in the Department of Pharmacology &#038; Experimental Therapeutics. Her pre-doctoral dissertation studies focused on elucidating molecular and cellular mechanisms involved in enhanced functional recovery in monkeys treated with mesenchymal stem cell-derived extracellular vesicles following cortical injury. Veronica is now a Senior Scientist at NeuroTrauma Sciences, LLC.<\/p>\n<\/div>\n<div>\n<img loading=\"lazy\" src=\"\/anatneuro\/files\/2013\/01\/Mary-Orczykowski.jpg\" alt=\"\" width=\"100\" height=\"100\"><\/p>\n<h4>Mary Orczykowski<\/h4>\n<p>Mary investigated the role of umbilical derived stem cells as a therapy to facilitate recovery of fine motor function following cortical injury to the hand representation in primary motor cortex in young rhesus monkeys. Mary is Lecturer in the Division of Anatomical Sciences, Department of Surgery at the University of Michigan Medical School.<\/p>\n<\/div>\n<div>\n<h2>Recent Publications<\/h2>\n<p><b>Moore, TL,<\/b> Medalla, M, Iba\u00f1ez, S, Wimmer, K, Mojica, CA, Killiany, RJ, Moss, MB,<br \/>\nLuebke, JI and Rosene, DL. 2023 Neuronal properties of pyramidal cells in lateral<br \/>\nprefrontal cortex of the aging rhesus monkey brain are associated with performance<br \/>\ndeficits on spatial working memory but not executive function. Geroscience, DOI:<br \/>\n10.1101\/2023.02.07.527321. PubMed PMID: 36798388; PubMed Central PMCID:<br \/>\nPMC9934587.<\/p>\n<p>Campbell, NB, Patel, Y, <b>Moore, TL,<\/b> Medalla, M and Zeldich. E. (2023) Extracellular<br \/>\nVesicle treatment alleviates neurodevelopmental and neurodegenerative pathology<br \/>\nin cortical spheroid model of Down Syndrome. International Journal of Molecular<br \/>\nSciences. Feb 9;24(4):3477. doi: 10.3390\/ijms24043477. PubMed PMID: 36834891;<br \/>\nPubMed Central PMCID: PMC9960302.<\/p>\n<p>Welke, LA, Rosene, DL, Killiany, RJ, Moss, MB and <b>Moore, TL.<\/b> (2023) Prefrontal<br \/>\nand medial temporal interactions in memory functions in the rhesus monkey.<br \/>\nBehavioral Neuroscience, DOI: 10.1037\/bne0000556. PubMed PMID: 37023305;<br \/>\nPubMed Central PMCID: PMC10192048.<\/p>\n<p>Calderazzo, SM, Covert, M, De Alba, D, Bowley, BGE, Pessina, M, Rosene, DL,<br \/>\nMedalla, M, Buller, B and <b>Moore, TL.<\/b> (2022) Neural recovery after cortical injury:<br \/>\neffects of MSC derived extracellular vesicles on motor circuit remodeling. IBRO<br \/>\nNeuroscience Reports. PubMed PMID: 36590089; PubMed Central PMCID:<br \/>\nPMC9795302<\/p>\n<p>Baxi, M, Karayumak, SC, Papadimitriou, G, Makris, N, Van Der Kouwe, A, Jenkins,<br \/>\nB, <b>Moore, T,<\/b> Rosene, DL, Kubicki and Rathi, Y. (2022). Investigating the contribution<br \/>\nof cytoarchitecture to diffusion MRI measures in gray matter using histology.<br \/>\nFrontiers in Neuroimaging, Sec. Brain Imaging Methods. PubMed PMID: 37555179;<br \/>\nPubMed Central PMCID: PMC10406256<\/p>\n<p>Dimovasili, C, Fair, A, Garza, I, Batterman, K, Mortazavi, F, <b>Moore, TL,<\/b> and Rosene,<br \/>\nDL. (2022). Aging Compromises Oligodendrocyte Precursor Cell Maturation and<br \/>\nEfficient Remyelination in The Monkey Brain. Geroscience. PubMed PMID:<br \/>\n35930094; PubMed Central PMCID: PMC9886778.<\/p>\n<p>Chang, W, Weaver, CM, Medalla, M, <b>Moore, TL,<\/b> and Luebke, JI. (2022). Age-related<br \/>\nalterations to working memory and to pyramidal neurons in the prefrontal cortex of<br \/>\nrhesus monkeys begin in early middle-age and are partially ameliorated by dietary<br \/>\ncurcumin. Neurobiology of Aging, 109, 113-124. PubMed PMID: 34715442; PubMed<br \/>\nCentral PMCID: PMC8671373.<\/p>\n<p>Uprety, A, Moss, MB, Rosene, DL, Killiany, RJ and <b>Moore, TL<\/b> (2022) Curcumin<br \/>\nSupplementation Improves Reversal Learning in Middle Aged Rhesus Monkeys.<br \/>\nBehavioral Neuroscience, 136(2), 126-138. PMID: 34780208<\/p>\n<p>Zhang, J, Buller, BA, Zhang, ZG, Zhang, Y, Lu, M, Rosene, DL, Medalla, M,<br \/>\n<b>Moore, TL,<\/b> and Chopp, M. (2022) Exosomes derived from bone marrow<br \/>\nmesenchymal stromal cells promote remyelination and reduce neuroinflammation in<br \/>\nthe demyelinating central nervous system, Experimental Neurology, 347. PubMed<br \/>\nPMID: 34653510<\/p>\n<p><b>Moore, TL,<\/b> Young, DA, Killiany, RJ, Volfson, D and Kozak, R. (2021) The Effects of<br \/>\na Novel Non-Catechol Dopamine Partial Agonist on Working Memory in the Aged<br \/>\nRhesus Monkey. Frontiers in Aging Neuroscience, 13:757850. doi:<br \/>\n10.3389\/fnagi.2021.757850. PMID: 34899271 PMCID: PMC8662559<\/p>\n<p>Bottenfield, KR, Bowley, BGE, Pessina , MA, Medalla, M, Rosene , DL and <b>Moore, TL.<\/b><br \/>\n(2021) Sex Differences in Recovery of Motor Function in a Rhesus Monkey Model of<br \/>\nCortical Injury. Biology of Sex Differences. PubMed PMID: 34627376; PubMed<br \/>\nCentral PMCID: PMC8502310<\/p>\n<p>Medalla, M, Chang, W, Iba\u00f1ez, S, Guillamon-Vivancos, T, Nitttmann, M, Kapitonava,<br \/>\nA, Busch, SE, <b>Moore, TL,<\/b> Rosene, DL and Luebke, JI. (2022) Layer-specific<br \/>\npyramidal neuron properties underlie diverse anterior cingulate cortical motor and<br \/>\nlimbic networks. Cerebral Cortex, 32(10):2170-2196. PubMed PMID: 34613380;<br \/>\nPubMed Central PMCID: PMC9113240<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<style>\n<p>.offset {\n  box-shadow: 0.3em 0.3em 0 0 var(--color), inset 0.3em 0.3em 0 0 var(--color);\n}\n.offset:hover, .offset:focus {\n  box-shadow: 0 0 0 0 var(--hover), inset 6em 3.5em 0 0 var(--hover);\n}<\/p>\n<p>.offset {\n  --color: #262262;\n  --hover: #262262;\n}<\/p>\n<p>button {\n  color: var(--color);\n  transition: 0.25s;\n}\nbutton:hover, button:focus {\n  border-color: var(--hover);\n  color: #fff;\n}<\/p>\n<p>button {\n  background: none;\n  border: 2px solid;\n  font-size: 14px;\n  font-family: 'Open Sans', sans-serif;\n  line-height: 1;\n  margin: 0.5em;\n  padding: 1em 2em;\n  max-width: 80vw;\n}<\/p>\n<p>\/* ----------------Animated Button---------------- *\/<\/p>\n<p>.gradient-btn {\n  \/* Fallback: Set a background color. *\/\n  background-color: #262262;<\/p>\n<p>  \/* Create the gradient. *\/\n  background-image: linear-gradient(\n    45deg,\n    #ffffff 50%,\n    #262262 50%\n  );<\/p>\n<p>  \/* Set the background size and repeat properties. *\/\n  background-size: 270%;\n  background-repeat: repeat;\n  background-position: top right;<\/p>\n<p>  \/* Use the text as a mask for the background. *\/\n  \/* This will show the gradient as a text color rather than element bg. *\/\n  -webkit-background-clip: text;\n  -webkit-text-fill-color: transparent; \n  -moz-background-clip: text;\n  -moz-text-fill-color: transparent;<\/p>\n<p>  animation: button-animation 0.65s 0.15s ease-out forwards;\n}<\/p>\n<p>a.btn:hover, a.btn:hover span{\n    animation: button-animation-rev 0.65s ease-out forwards;\n}<\/p>\n<p>a.btn:hover {\n  box-shadow: 3px 2px 10px 1px rgba(0,0,0,0.15);\n  transition: 0.5s;\n}<\/p>\n<p>@keyframes button-animation {\n  0% {\n    background-position: top right;\n  }\n  100% {\n    background-position: top left;\n  }\n}<\/p>\n<p>@keyframes button-animation-rev {\n  0% {\n    background-position: top left;\n  }\n  100% {\n    background-position: top right;\n  }\n}<\/p>\n<p>a.btn {\n  margin-top: 1em;\n  margin-left: auto;\n  margin-right: auto;\n  background-image: linear-gradient(45deg, #262262 50%, #ffffff 50%);\n  background-size: 270%;\n  background-repeat: repeat;\n  background-position: top right;\n  animation: button-animation 0.65s 0.15s ease-out forwards;\n  display: table;\n  border-radius: 0.5em;\n  text-decoration: none;\n  box-shadow: 7px 4px 20px 1px rgba(0,0,0,0.15);\n  padding: 1.5em 0;\n  cursor: pointer;\n  width: 80%;\n  text-align: center;\n}<\/p>\n<p>a.btn span {\n  font-family: 'Open Sans', sans-serif;\n  font-weight: bold;\n  font-size: 2em;\n  text-align: center;\n  margin-bottom: 0;\n  margin-bottom: -0.25em;\n  width: 100%;\n  padding: 0 1.5em;\n}<\/p>\n<p>* {\n  margin: 0;\n  box-sizing: border-box;\n}<\/p>\n<p>.universal-pad {\n    margin: 25px;\n    margin-left: 150px;\n    margin-right: 150px;\n}<\/p>\n<p>ul {\n    font-size: 15px;\n}<\/p>\n<\/style>\n","protected":false},"excerpt":{"rendered":"<p>Interventions for Cortical Injury &#038; Cognitive Decline Interventions for Cortical Injury &#038; Cognitive Decline Lab Director: Tara Moore Ph.D. Our laboratory for Interventions for Cortical Injury and Cognitive Decline focuses its research efforts on studying cognitive abilities and motor impairments across the lifespan and following cortical injury in the rhesus monkey. Specifically, we examine age-related [&hellip;]<\/p>\n","protected":false},"author":18550,"featured_media":0,"parent":0,"menu_order":56,"comment_status":"closed","ping_status":"closed","template":"page-templates\/no-sidebars.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/9305"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/users\/18550"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/comments?post=9305"}],"version-history":[{"count":50,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/9305\/revisions"}],"predecessor-version":[{"id":12694,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/9305\/revisions\/12694"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/media?parent=9305"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}