{"id":9231,"date":"2021-09-20T20:30:11","date_gmt":"2021-09-21T00:30:11","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/anatneuro\/?page_id=9231"},"modified":"2024-08-23T16:30:04","modified_gmt":"2024-08-23T20:30:04","slug":"ella-zeldich","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/anatneuro\/ella-zeldich\/","title":{"rendered":"Ella Zeldich"},"content":{"rendered":"<\/div>\n<p><!-- ___________________Navbar___________________ --><\/p>\n<div id=\"navvy\"><\/div>\n<p><script type=\"text\/javascript\" src=\"\/anatneuro\/files\/2022\/01\/nav.js\"><\/script><\/p>\n<p><!-- ___________________Banner___________________ --><\/p>\n<div class=\"mobile-title mobile-banner\">\n<p class=\"mobile-header\">Ella Zeldich<\/p>\n<\/div>\n<div class=\"profile-parallax\">\n<div class=\"true-nav nav-border\"><\/div>\n<div style=\"width: 40%; float: left;\" class=\"title-padding\">\n<p class=\"title-header\">Ella Zeldich<\/p>\n<p class=\"title-header2\" style=\"text-align: left;\">Assistant Professor<\/p>\n<\/div>\n<div style=\"width: 40%; float: right;\">\n<img loading=\"lazy\" style=\"padding-top: 50px;\" width=\"320\" height=\"320\" src=\"\/anatneuro\/files\/2024\/08\/Ella-picture.png\" alt=\"\">\n<\/div>\n<\/div>\n<p><!-- ___________________Profiles___________________ --><\/p>\n<div class=\"universal-pad\">\n<div class=\"col-md-8\">\n<p>Dr. Zeldich obtained her Ph.D. degree at the Department of Physiology and Pharmacology in Tel Aviv University, Israel. In 2011, Dr. Zeldich joined the Department of Biochemistry as a postdoctoral associate. Her research was focused on characterization of the molecular mechanisms leading to normal brain aging and the pathological processes associated with Alzheimer\u2019s disease (AD) and multiple sclerosis (MS). Specifically, she explored the role of anti-aging Klotho protein in the brain as a target for prevention and treatment of neurodegenerative and demyelinating disorders such as AD, MS, and Amyotrophic Lateral Sclerosis (ALS) utilizing principles of basic and translational research.<\/p>\n<p>Dr. Zeldich joined the Department of Anatomy and Neurobiology in December 2018. Her current research is focused on elucidating molecular and cellular mechanisms underlying the abnormal myelination associated with Down Syndrome (DS) and understanding the source of the defective communication between the glial and neuronal cells. One of the main goals of her research is to understand the molecular and cellular mechanisms that can explain the high prevalence of Alzheimer\u2019s disease among DS individuals. In particular, Dr. Zeldich is investigating the connection between oligodendrocyte lineage establishment and maturation and myelin stability in the development of Alzheimer\u2019s-related pathology. In her studies, she is using an advanced 3D cellular model derived from induced pluripotential stem (iPS) cells generated from individuals with DS. This cellular model, known as oligocortical spheroids, enables generation of oligodendrocyte, astrocyte, and neuronal populations in a comprehensive and dynamic environment for studying myelination processes in human cells. Dr. Zeldich expertise includes gene editing, translational research, confocal microscopy, immunostaining, RNAscope, Patch-seq and RNA-seq based methodologies.<\/p>\n<p>Lab Site: <a href=\"https:\/\/www.bumc.bu.edu\/anatneuro\/ella-zeldich-lab\/\">Zeldich Lab<\/a><\/p>\n<\/div>\n<div class=\"col-md-4\">\n<div class=\"block-pad\">\n<div class=\"block\">\n<p style=\"font-weight: bold;\">RESEARCH:<\/p>\n<p style=\"text-align: left;\">Down Syndrome, Myelin abnormalities, cellular IPS-derived models<\/p>\n<p style=\"font-weight: bold;\">OFFICE:<\/p>\n<p>L-810<\/p>\n<p style=\"font-weight: bold;\">EMAIL:<\/p>\n<p>ezeldich@bu.edu<\/p>\n<p style=\"font-weight: bold;\">PHONE:<\/p>\n<p>617-358-0811<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"padding-bottom: 20px;\">\n<a href=\"https:\/\/www.bumc.bu.edu\/anatneuro\/faculty\/\" class=\"btn\" style=\"width: 60vw;\"><br \/>\n  <span class=\"gradient-btn\">Faculty<\/span><br \/>\n<\/a>\n<\/div>\n<style>\n<p>article.post-12483 {\n   display: none;\n}<\/p>\n<p>\/* ----------------Blocks---------------- *\/<\/p>\n<p>.block {\n    background-color: #ffffff;\n    padding: 15px;\n    margin: auto;\n    height: 550px;\n    width: 300px;\n    border-radius: 3px;\n    align-items: center;\n    z-index: 2;\n    box-shadow: -50px 0 100px -50px #808080, 50px 0 100px -50px #808080;\n}<\/p>\n<p>.block-pad {\n    margin-top: 20px;\n    margin-bottom: 20px;\n}<\/p>\n<p>@media only screen and (min-width: 760px) {\n\t.block {\n\t\twidth: 300px;\n             height: 550px;\n\t}\n}<\/p>\n<p>.block h1 {\n    padding-bottom: 5px;\n    font-size: 24px;\n    text-align: center;\n}<\/p>\n<p>\/* ----------------Profile---------------- *\/<\/p>\n<p>.side-info {\n    background-color: #ffffff;\n}<\/p>\n<p>.universal-pad {\n    margin: 25px;\n    margin-left: 10vw;\n    margin-right: 10vw;\n}<\/p>\n<p>.firstinfo{\n  display: flex;\n  justify-content: center;\n  align-items: center;\n}<\/p>\n<p>.content1 {\n  position: relative;\n  animation: animatop 0.9s cubic-bezier(0.425, 1.14, 0.47, 1.125) forwards;\n  margin-left: 12vw;\n  margin-top: 10px;\n  margin-bottom: 10px;\n}<\/p>\n<p>.card {\n  width: 70vw;\n  min-height: 100px;\n  padding: 20px;\n  border-radius: 3px;\n  background-color: white;\n  box-shadow: 0px 10px 20px rgba(0, 0, 0, 0.2);\n  position: relative;\n  overflow: hidden;\n}\n.card:after {<\/p>\n<p>}<\/p>\n<p>.firstinfo {\n  flex-direction: row;\n  z-index: 2;\n  position: relative;\n}\n.firstinfo img {\n  display: none;\n}\n.firstinfo .profileinfo {\n  padding: 0px 20px;\n}\n.firstinfo .profileinfo h1 {\n  font-size: 35px;\n}\n.firstinfo .profileinfo h3 {\n  font-size: 20px;\n  color: #262262;\n  font-style: italic;\n}\n.firstinfo .profileinfo p.bio {\n  padding: 10px 0px;\n  color: #5A5A5A;\n  line-height: 1.2;\n  font-style: initial;\n}<\/p>\n<p>@keyframes animatop {\n  0% {\n    opacity: 0;\n    bottom: -500px;\n  }\n  100% {\n    opacity: 1;\n    bottom: 0px;\n  }\n}\n@keyframes animainfos {\n  0% {\n    bottom: 10px;\n  }\n  100% {\n    bottom: -42px;\n  }\n}\n@keyframes rotatemagic {\n  0% {\n    opacity: 0;\n    transform: rotate(0deg);\n    top: -24px;\n    left: -253px;\n  }\n  100% {\n    transform: rotate(-30deg);\n    top: -24px;\n    left: -78px;\n  }\n}<\/p>\n<p>@media only screen and (min-width: 900px) {\n.card:after {\n  content: \"\";\n  display: block;\n  width: 190px;\n  height: 300px;\n  background: #262262;\n  position: absolute;\n  animation: rotatemagic 0.75s cubic-bezier(0.425, 1.04, 0.47, 1.105) 1s both;\n}<\/p>\n<p>.firstinfo img {\n  border-radius: 50%;\n  width: 120px;\n  height: 120px;\ndisplay: block;\n}<\/p>\n<p>}\n\/* ----------------Animated Button---------------- *\/<\/p>\n<p>.gradient-btn {\n  \/* Fallback: Set a background color. *\/\n  background-color: #262262;<\/p>\n<p>  \/* Create the gradient. *\/\n  background-image: linear-gradient(\n    45deg,\n    #ffffff 50%,\n    #262262 50%\n  );<\/p>\n<p>  \/* Set the background size and repeat properties. *\/\n  background-size: 270%;\n  background-repeat: repeat;\n  background-position: top right;<\/p>\n<p>  \/* Use the text as a mask for the background. *\/\n  \/* This will show the gradient as a text color rather than element bg. *\/\n  -webkit-background-clip: text;\n  -webkit-text-fill-color: transparent; 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In 2011, Dr. Zeldich joined the Department of Biochemistry as a postdoctoral associate. Her research was focused on characterization of the molecular mechanisms leading to normal brain aging and the pathological [&hellip;]<\/p>\n","protected":false},"author":18550,"featured_media":0,"parent":0,"menu_order":32,"comment_status":"closed","ping_status":"closed","template":"page-templates\/no-sidebars.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/9231"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/users\/18550"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/comments?post=9231"}],"version-history":[{"count":16,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/9231\/revisions"}],"predecessor-version":[{"id":12396,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/9231\/revisions\/12396"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/media?parent=9231"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}