{"id":11917,"date":"2023-09-06T19:23:07","date_gmt":"2023-09-06T23:23:07","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/anatneuro\/?page_id=11917"},"modified":"2023-11-13T11:01:03","modified_gmt":"2023-11-13T16:01:03","slug":"ben-wolozin","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/anatneuro\/ben-wolozin\/","title":{"rendered":"Ben Wolozin"},"content":{"rendered":"<\/div>\n<p><!-- ___________________Navbar___________________ --><\/p>\n<div id=\"navvy\"><\/div>\n<p><script type=\"text\/javascript\" src=\"\/anatneuro\/files\/2023\/08\/nav-08-2023.js\"><\/script><\/p>\n<p><!-- ___________________Banner___________________ --><\/p>\n<div class=\"mobile-title mobile-banner\">\n<p class=\"mobile-header\">Ben Wolozin<\/p>\n<\/div>\n<div class=\"profile-parallax\">\n<div class=\"true-nav nav-border\"><\/div>\n<div style=\"width: 40%; float: left;\" class=\"title-padding\">\n<p class=\"title-header\">Ben Wolozin<\/p>\n<p class=\"title-header2\" style=\"text-align: left;\">Professor<\/p>\n<\/div>\n<div style=\"width: 40%; float: right;\">\n<img loading=\"lazy\" style=\"padding-top: 50px;\" width=\"320\" height=\"320\" src=\"\/anatneuro\/files\/2023\/09\/Ben-Wolozin-Headshot.png\" alt=\"\">\n<\/div>\n<\/div>\n<p><!-- ___________________Profiles___________________ --><\/p>\n<div class=\"universal-pad\">\n<div class=\"col-md-8\">\n<p><b>Overview:<\/b>\u00a0The goal of our research is to understand the mechanisms<br \/>\nunderlying neurodegenerative diseases, and then to use this understanding to<br \/>\ndevelop novel interventions for disease.\u00a0 Much of our research focuses on the<br \/>\ncentral concept of regulated protein aggregation.\u00a0\u00a0Protein aggregation in<br \/>\nneurodegenerative diseases is classically thought to occur as an unwanted<br \/>\nbyproduct of protein misfolding.\u00a0 Human genetic studies increasingly highlight<br \/>\nthe importance of RNA binding proteins in neurodegenerative diseases.\u00a0 This<br \/>\nis important because RNA binding proteins use protein aggregation as part of<br \/>\na normal regulated, physiological mechanism controlling protein synthesis.<br \/>\n\u00a0Aggregated RNA binding proteins for stress granules, transport granules, P<br \/>\nbodies, as well as participate in physiological functions, such as activity<br \/>\ndependent protein synthesis.\u00a0 Our research investigates the hypothesis that<br \/>\ndysfunction of RNA granules causes neurodegenerative diseases.\u00a0 Over<br \/>\nactive stress granule formation could contribute to neurodegeneration by<br \/>\naltering patterns of protein synthesis and sequestering proteins that regulate<br \/>\ncell death processes.\u00a0 Hypo-active stress granules, leads to inadequate<br \/>\nneuroprotection.<\/p>\n<p><strong>Lab:&nbsp;<\/strong><a title=\"Laboratory of Neurodegeneration\" href=\"https:\/\/sites.bu.edu\/wolozinlab\/\" target=\"_self\" rel=\"noopener noreferrer\"><span class=\"standard\"><span>Laboratory of Neurodegeneration<\/span><\/span><\/a><\/p>\n<p><strong>CV:<\/strong><span>&nbsp;<\/span><a href=\"\/anatneuro\/files\/2023\/09\/Wolozin-CV-long.pdf\">Wolozin, M.D., Ph.D. \u2014 CV<\/a><\/p>\n<\/div>\n<div class=\"col-md-4\">\n<div class=\"block-pad\">\n<div class=\"block\">\n<p style=\"font-weight: bold;\">RESEARCH:<\/p>\n<p style=\"text-align: left;\">Pathophysiology of Neurodegeneration: Molecular and cellular Biology<\/p>\n<p style=\"font-weight: bold;\">OFFICE:<\/p>\n<p>Office: R-614; 650 Albany St., CAMED<\/p>\n<p style=\"font-weight: bold;\">EMAIL:<\/p>\n<p>bwolozin@bu.edu<\/p>\n<p style=\"font-weight: bold;\">PHONE:<\/p>\n<p>617-358-1995<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"padding-bottom: 20px;\">\n<a href=\"https:\/\/www.bumc.bu.edu\/anatneuro\/faculty\/\" class=\"btn\" style=\"width: 60vw;\"><br \/>\n  <span class=\"gradient-btn\">Faculty<\/span><br \/>\n<\/a>\n<\/div>\n<style>\n<p>article.post-12186 {\n   display: none;\n}<\/p>\n<p>\/* ----------------Blocks---------------- *\/<\/p>\n<p>.block {\n    background-color: #ffffff;\n    padding: 15px;\n    margin: auto;\n    height: 550px;\n    width: 300px;\n    border-radius: 3px;\n    align-items: center;\n    z-index: 2;\n    box-shadow: -50px 0 100px -50px #808080, 50px 0 100px -50px #808080;\n}<\/p>\n<p>.block-pad {\n    margin-top: 20px;\n    margin-bottom: 20px;\n}<\/p>\n<p>@media only screen and (min-width: 760px) {\n\t.block {\n\t\twidth: 300px;\n             height: 550px;\n\t}\n}<\/p>\n<p>.block h1 {\n    padding-bottom: 5px;\n    font-size: 24px;\n    text-align: center;\n}<\/p>\n<p>\/* ----------------Profile---------------- *\/<\/p>\n<p>.side-info {\n    background-color: #ffffff;\n}<\/p>\n<p>.universal-pad {\n    margin: 25px;\n    margin-left: 10vw;\n    margin-right: 10vw;\n}<\/p>\n<p>.firstinfo{\n  display: flex;\n  justify-content: center;\n  align-items: center;\n}<\/p>\n<p>.content1 {\n  position: relative;\n  animation: animatop 0.9s cubic-bezier(0.425, 1.14, 0.47, 1.125) forwards;\n  margin-left: 12vw;\n  margin-top: 10px;\n  margin-bottom: 10px;\n}<\/p>\n<p>.card {\n  width: 70vw;\n  min-height: 100px;\n  padding: 20px;\n  border-radius: 3px;\n  background-color: white;\n  box-shadow: 0px 10px 20px rgba(0, 0, 0, 0.2);\n  position: relative;\n  overflow: hidden;\n}\n.card:after {<\/p>\n<p>}<\/p>\n<p>.firstinfo {\n  flex-direction: row;\n  z-index: 2;\n  position: relative;\n}\n.firstinfo img {\n  display: none;\n}\n.firstinfo .profileinfo {\n  padding: 0px 20px;\n}\n.firstinfo .profileinfo h1 {\n  font-size: 35px;\n}\n.firstinfo .profileinfo h3 {\n  font-size: 20px;\n  color: #262262;\n  font-style: italic;\n}\n.firstinfo .profileinfo p.bio {\n  padding: 10px 0px;\n  color: #5A5A5A;\n  line-height: 1.2;\n  font-style: initial;\n}<\/p>\n<p>@keyframes animatop {\n  0% {\n    opacity: 0;\n    bottom: -500px;\n  }\n  100% {\n    opacity: 1;\n    bottom: 0px;\n  }\n}\n@keyframes animainfos {\n  0% {\n    bottom: 10px;\n  }\n  100% {\n    bottom: -42px;\n  }\n}\n@keyframes rotatemagic {\n  0% {\n    opacity: 0;\n    transform: rotate(0deg);\n    top: -24px;\n    left: -253px;\n  }\n  100% {\n    transform: rotate(-30deg);\n    top: -24px;\n    left: -78px;\n  }\n}<\/p>\n<p>@media only screen and (min-width: 900px) {\n.card:after {\n  content: \"\";\n  display: block;\n  width: 190px;\n  height: 300px;\n  background: #262262;\n  position: absolute;\n  animation: rotatemagic 0.75s cubic-bezier(0.425, 1.04, 0.47, 1.105) 1s both;\n}<\/p>\n<p>.firstinfo img {\n  border-radius: 50%;\n  width: 120px;\n  height: 120px;\ndisplay: block;\n}<\/p>\n<p>}\n\/* ----------------Animated Button---------------- *\/<\/p>\n<p>.gradient-btn {\n  \/* Fallback: Set a background color. *\/\n  background-color: #262262;<\/p>\n<p>  \/* Create the gradient. *\/\n  background-image: linear-gradient(\n    45deg,\n    #ffffff 50%,\n    #262262 50%\n  );<\/p>\n<p>  \/* Set the background size and repeat properties. *\/\n  background-size: 270%;\n  background-repeat: repeat;\n  background-position: top right;<\/p>\n<p>  \/* Use the text as a mask for the background. *\/\n  \/* This will show the gradient as a text color rather than element bg. *\/\n  -webkit-background-clip: text;\n  -webkit-text-fill-color: transparent; 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