{"id":11506,"date":"2023-02-05T13:09:13","date_gmt":"2023-02-05T18:09:13","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/anatneuro\/?page_id=11506"},"modified":"2023-02-11T17:28:55","modified_gmt":"2023-02-11T22:28:55","slug":"joseph-martinez","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/anatneuro\/joseph-martinez\/","title":{"rendered":"Joseph M. Martinez, PhD"},"content":{"rendered":"<\/div>\n<p><!-- ___________________Navbar___________________ --><\/p>\n<div id=\"navvy\"><\/div>\n<p><script type=\"text\/javascript\" src=\"\/anatneuro\/files\/2023\/02\/nav-2023.js\"><\/script><\/p>\n<p><!-- ___________________Banner___________________ --><\/p>\n<div class=\"mobile-title mobile-banner\">\n<p class=\"mobile-header\">Joseph M. Martinez, PhD<\/p>\n<\/div>\n<div class=\"profile-parallax\">\n<div class=\"true-nav nav-border\"><\/div>\n<div style=\"width: 40%; float: left;\" class=\"title-padding\">\n<p class=\"title-header\">Joseph M. Martinez, PhD<\/p>\n<p class=\"title-header2\" style=\"text-align: left;\">Postdoc<\/p>\n<\/div>\n<div style=\"width: 40%; float: right;\">\n<img loading=\"lazy\" style=\"padding-top: 50px; border-radius: 50%;\" width=\"320\" height=\"320\" src=\"\/anatneuro\/files\/2023\/02\/JosephMMartinez-scaled-e1675399211715.jpg\" alt=\"\">\n<\/div>\n<\/div>\n<p><!-- ___________________Profiles___________________ --><\/p>\n<div class=\"universal-pad\">\n<div class=\"col-md-12\">\n<p>The Wallace Lab studies how specific circuits within the basal ganglia guide motivated behaviors, control goal-oriented motor actions, and how these circuits are affected under stress or in disease conditions.  The process of selecting an action, evaluating, and storing the outcome to inform future responses has long been known to require the basal ganglia and lateral habenula (LHb) though the exact role LHb plays in this process remains undefined. Dr. Martinez\u2019s project addresses this knowledge gap by seeking to determine the mechanistic role genetically and anatomically defined neuronal subfields of the LHb play in action selection during both normal and stressed conditions. Previously, the Lab has defined genetically distinct neuronal subtypes within the LHb and has developed a variation of a 2-armed bandit behavioral task (2ABT).  The 2ABT tests the ability of an animal to select an action to receive a reward from two choices using previously learned information. Using this task along with genetically targeted viral constructs for biosensors or gene knockout, Dr. Martinez can manipulate and observe LHb circuit dynamics in vivo in a behaving animal.  Utilizing these tools, Dr. Martinez will test the hypotheses that distinct, genetically defined LHb neuronal subtypes encode the action, the outcome, or both to differentially control action selection behavior and that perturbed activity in LHb neuronal subtypes underlies stress induced alterations in action selection. We hypothesize that, at least partially, perturbed adrenergic signaling plays a role in this process and will seek to elucidate the role adrenergic signaling plays in the LHb in normal and stressed conditions using these same techniques.  This project utilizes the techniques and skills present in the Wallace Lab while also leveraging my expertise in subcellular adrenergic signaling in both learning and stress.<\/p>\n<\/div>\n<\/div>\n<div style=\"padding-bottom: 20px;\">\n<a href=\"https:\/\/www.bumc.bu.edu\/anatneuro\/postdocs\/\" class=\"btn\" style=\"width: 60vw;\"><br \/>\n  <span class=\"gradient-btn\">Postdocs<\/span><br \/>\n<\/a>\n<\/div>\n<style>\n<p>article.post-12186 {\n   display: none;\n}<\/p>\n<p>\/* ----------------Blocks---------------- *\/<\/p>\n<p>.block {\n    background-color: #ffffff;\n    padding: 15px;\n    margin: auto;\n    height: 550px;\n    width: 300px;\n    border-radius: 3px;\n    align-items: center;\n    z-index: 2;\n    box-shadow: -50px 0 100px -50px #808080, 50px 0 100px -50px #808080;\n}<\/p>\n<p>.block-pad {\n    margin-top: 20px;\n    margin-bottom: 20px;\n}<\/p>\n<p>@media only screen and (min-width: 760px) {\n\t.block {\n\t\twidth: 300px;\n             height: 550px;\n\t}\n}<\/p>\n<p>.block h1 {\n    padding-bottom: 5px;\n    font-size: 24px;\n    text-align: center;\n}<\/p>\n<p>\/* ----------------Profile---------------- *\/<\/p>\n<p>.side-info {\n    background-color: #ffffff;\n}<\/p>\n<p>.universal-pad {\n    margin: 25px;\n    margin-left: 10vw;\n    margin-right: 10vw;\n}<\/p>\n<p>.firstinfo{\n  display: flex;\n  justify-content: center;\n  align-items: center;\n}<\/p>\n<p>.content1 {\n  position: relative;\n  animation: animatop 0.9s cubic-bezier(0.425, 1.14, 0.47, 1.125) forwards;\n  margin-left: 12vw;\n  margin-top: 10px;\n  margin-bottom: 10px;\n}<\/p>\n<p>.card {\n  width: 70vw;\n  min-height: 100px;\n  padding: 20px;\n  border-radius: 3px;\n  background-color: white;\n  box-shadow: 0px 10px 20px rgba(0, 0, 0, 0.2);\n  position: relative;\n  overflow: hidden;\n}\n.card:after {<\/p>\n<p>}<\/p>\n<p>.firstinfo {\n  flex-direction: row;\n  z-index: 2;\n  position: relative;\n}\n.firstinfo img {\n  display: none;\n}\n.firstinfo .profileinfo {\n  padding: 0px 20px;\n}\n.firstinfo .profileinfo h1 {\n  font-size: 35px;\n}\n.firstinfo .profileinfo h3 {\n  font-size: 20px;\n  color: #262262;\n  font-style: italic;\n}\n.firstinfo .profileinfo p.bio {\n  padding: 10px 0px;\n  color: #5A5A5A;\n  line-height: 1.2;\n  font-style: initial;\n}<\/p>\n<p>@keyframes animatop {\n  0% {\n    opacity: 0;\n    bottom: -500px;\n  }\n  100% {\n    opacity: 1;\n    bottom: 0px;\n  }\n}\n@keyframes animainfos {\n  0% {\n    bottom: 10px;\n  }\n  100% {\n    bottom: -42px;\n  }\n}\n@keyframes rotatemagic {\n  0% {\n    opacity: 0;\n    transform: rotate(0deg);\n    top: -24px;\n    left: -253px;\n  }\n  100% {\n    transform: rotate(-30deg);\n    top: -24px;\n    left: -78px;\n  }\n}<\/p>\n<p>@media only screen and (min-width: 900px) {\n.card:after {\n  content: \"\";\n  display: block;\n  width: 190px;\n  height: 300px;\n  background: #262262;\n  position: absolute;\n  animation: rotatemagic 0.75s cubic-bezier(0.425, 1.04, 0.47, 1.105) 1s both;\n}<\/p>\n<p>.firstinfo img {\n  border-radius: 50%;\n  width: 120px;\n  height: 120px;\ndisplay: block;\n}<\/p>\n<p>}\n\/* ----------------Animated Button---------------- *\/<\/p>\n<p>.gradient-btn {\n  \/* Fallback: Set a background color. *\/\n  background-color: #262262;<\/p>\n<p>  \/* Create the gradient. *\/\n  background-image: linear-gradient(\n    45deg,\n    #ffffff 50%,\n    #262262 50%\n  );<\/p>\n<p>  \/* Set the background size and repeat properties. *\/\n  background-size: 270%;\n  background-repeat: repeat;\n  background-position: top right;<\/p>\n<p>  \/* Use the text as a mask for the background. *\/\n  \/* This will show the gradient as a text color rather than element bg. *\/\n  -webkit-background-clip: text;\n  -webkit-text-fill-color: transparent; \n  -moz-background-clip: text;\n  -moz-text-fill-color: transparent;<\/p>\n<p>  animation: button-animation 0.65s 0.15s ease-out forwards;\n}<\/p>\n<p>a.btn:hover, a.btn:hover span{\n    animation: button-animation-rev 0.65s ease-out forwards;\n}<\/p>\n<p>a.btn:hover {\n  box-shadow: 3px 2px 10px 1px rgba(0,0,0,0.15);\n  transition: 0.5s;\n}<\/p>\n<p>@keyframes button-animation {\n  0% {\n    background-position: top right;\n  }\n  100% {\n    background-position: top left;\n  }\n}<\/p>\n<p>@keyframes button-animation-rev {\n  0% {\n    background-position: top left;\n  }\n  100% {\n    background-position: top right;\n  }\n}<\/p>\n<p>a.btn {\n  margin-top: 1em;\n  margin-left: auto;\n  margin-right: auto;\n  background-image: linear-gradient(45deg, #262262 50%, #ffffff 50%);\n  background-size: 270%;\n  background-repeat: repeat;\n  background-position: top right;\n  animation: button-animation 0.65s 0.15s ease-out forwards;\n  display: table;\n  border-radius: 0.5em;\n  text-decoration: none;\n  box-shadow: 7px 4px 20px 1px rgba(0,0,0,0.15);\n  padding: 1.5em 0;\n  cursor: pointer;\n  width: 80%;\n  text-align: center;\n}<\/p>\n<p>a.btn span {\n  font-family: 'Open Sans', sans-serif;\n  font-weight: bold;\n  font-size: 2em;\n  text-align: center;\n  margin-bottom: 0;\n  margin-bottom: -0.25em;\n  width: 100%;\n  padding: 0 1.5em;\n}<\/p>\n<p>* {\n  margin: 0;\n  box-sizing: border-box;\n}<\/p>\n<\/style>\n","protected":false},"excerpt":{"rendered":"<p>Joseph M. Martinez, PhD Joseph M. Martinez, PhD Postdoc The Wallace Lab studies how specific circuits within the basal ganglia guide motivated behaviors, control goal-oriented motor actions, and how these circuits are affected under stress or in disease conditions. The process of selecting an action, evaluating, and storing the outcome to inform future responses has [&hellip;]<\/p>\n","protected":false},"author":18550,"featured_media":0,"parent":0,"menu_order":94,"comment_status":"closed","ping_status":"closed","template":"page-templates\/no-sidebars.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/11506"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/users\/18550"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/comments?post=11506"}],"version-history":[{"count":3,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/11506\/revisions"}],"predecessor-version":[{"id":11545,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/11506\/revisions\/11545"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/media?parent=11506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}