{"id":10578,"date":"2022-02-18T21:46:03","date_gmt":"2022-02-19T02:46:03","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/anatneuro\/?page_id=10578"},"modified":"2025-05-06T11:54:22","modified_gmt":"2025-05-06T15:54:22","slug":"neural-circuits-ultrastructure","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/anatneuro\/neural-circuits-ultrastructure\/","title":{"rendered":"Medalla Lab"},"content":{"rendered":"<\/div>\n<p><!-- ___________________Navbar___________________ --><\/p>\n<div id=\"navvy\"><\/div>\n<p><script type=\"text\/javascript\" src=\"\/anatneuro\/files\/2025\/05\/nav-5-2025.js\"><\/script><\/p>\n<p><!-- ___________________Banner___________________ --><\/p>\n<div class=\"mobile-title mobile-banner\">\n<p class=\"mobile-header\">Laboratory of  Neural circuits and Ultrastructure<\/p>\n<\/div>\n<style>.mobile-banner{background-image: url(\"\/anatneuro\/files\/2022\/02\/banner.jpg\"); background-size: cover;}<\/style>\n<div class=\"blur\">\n<div class=\"medalla-parallax\">\n<div class=\"true-nav nav-border\"><\/div>\n<div class=\"title-padding\">\n<p style=\"padding-top: 0px;\" class=\"title-header\">Laboratory of  Neural circuits and Ultrastructure<\/p>\n<\/div>\n<\/div>\n<p><!-- ___________________Lab Details___________________ --><\/p>\n<div class=\"row\">\n<div class=\"col-md-12\">\n<div class=\"universal-pad\" style=\"margin-left: 2vw;\">\n<h2>Our Research<\/h2>\n<p>The major goal of our work is to understand how distinct limbic, sensory and motor networks interact and are controlled by the lateral prefrontal cortex (LPFC) and the anterior cingulate cortex (ACC) \u2013 key areas of the prefrontal  \u201cexecutive\u201d network. Given its dense connections with limbic structures such as the hippocampus and amygdala, the ACC is particularly important for cognitive-emotional integration and is selectively disrupted in many affective disorders such as depression and anxiety.<\/p>\n<\/div>\n<\/div>\n<div class=\"col-md-6\">\n<div class=\"universal-pad\" style=\"margin-left: 2vw;\">\n<div style=\"text-align: center;\">\n<p style=\"margin-left: 50px; margin-right: 50px;\">&#8211; How is this prefrontal &#8220;cognitive-emotional&#8221; network wired?<\/p>\n<p style=\"margin-left: 100px; margin-right: 50px;\">\n              &#8211; Within area microcircuitry<br \/>\n              &#8211; inter-areal connectivity<\/p>\n<p style=\"margin-left: 50px; margin-right: 50px;\">\n        &#8211; What makes cortico-limbic circuits vulnerable in neuropsychiatric disease?\n    <\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"col-md-6\">\n<img src=\"\/anatneuro\/files\/2022\/02\/brainword-1-e1645403526383.jpg\" style=\"width:300px; height:250px; margin: 0;\" class=\"info-img\">\n<\/div>\n<div class=\"col-md-12\">\n<div class=\"universal-pad\" style=\"margin-left: 2vw; margin-right: 2vw;\">\n<p>We combine cellular in vitro electrophysiological methods combined with optogenetic, multi-scale anatomic, and transcriptomic techniques to understand the biophysical and synaptic properties of neurons within functionally-related cortical networks. We utilize whole-cell patch-clamp recording, pathway tract-tracing, multiple immunohistochemical labeling, and 3D imaging techniques for light and electron microscopy (EM). We incorporate empirical data into biophysical network models to predict how diverse single-cell intrinsic and synaptic circuit properties can affect network dynamics.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p><!-- ___________________Buttons___________________ --><\/p>\n<div class=\"row fade\" style=\"margin: auto; padding-top: 30px; padding-bottom: 30px;\">\n<div class=\"col-lg-4\">\n<div class=\"button2\" style=\"margin: auto; margin-top: 20px; margin-bottom: 20px;\" onclick=\"document.body.classList.add('active')\">\n<p><a class=\"box-shade\" style=\"background-color: rgba(0,0,0,0);\"><\/a><br \/>\n<img style=\" width: 440px; height: 240px; object-fit: cover;\" src=\"\/anatneuro\/files\/2022\/02\/Box1.png\" alt=\"\"><br \/>\n<span style=\"z-index: 3; color: #ffffff; font-weight: normal; position: absolute;\" class=\"button-text\">Pathway tracing of prefrontal long-range connections<\/span><\/p>\n<div class=\"button-backgrounds\"><\/div>\n<\/div>\n<\/div>\n<div class=\"col-lg-4\">\n<div class=\"button2\" style=\"margin: auto; margin-top: 20px; margin-bottom: 20px;\" onclick=\"document.body.classList.add('active2')\">\n<p><a class=\"box-shade\"  style=\"background-color: rgba(0,0,0,0);\"><\/a><br \/>\n<img style=\" width: 440px; height: 240px; object-fit: cover;\" src=\"\/anatneuro\/files\/2022\/02\/Box2.png\" alt=\"\"><br \/>\n<span style=\"color: #ffffff; position: absolute; z-index: 3; font-weight: normal; letter-spacing: 1px;\" class=\"button-text\">Regional and laminar specialization of prefrontal excitatory and inhibitory microcircuits<\/span><\/p>\n<div class=\"button-backgrounds2\"><\/div>\n<\/div>\n<\/div>\n<div class=\"col-lg-4\">\n<div class=\"button2\" style=\"margin: auto; margin-top: 20px; margin-bottom: 20px;\" onclick=\"document.body.classList.add('activeC')\">\n<p><a class=\"box-shade\" style=\"background-color: rgba(0,0,0,0);\"><\/a><br \/>\n<img style=\" width: 440px; height: 240px; object-fit: cover;\" src=\"\/anatneuro\/files\/2022\/02\/Box3.png\" alt=\"\"><br \/>\n<span style=\"color: #ffffff; position: absolute; z-index: 3; font-weight: normal; margin: 20px;\" class=\"button-text\">Circuit plasticity in aging, injury and neurodegeneration<\/span><\/p>\n<div class=\"button-backgrounds2\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><!-- ___________________Pathway tracing... Popup___________________ --><\/p>\n<div class=\"wrapper1\">\n<div class=\"popup\">\n<div class=\"popup-inside\">\n<div class=\"backgrounds\">\n<div class=\"background\"><\/div>\n<div class=\"background background2\"><\/div>\n<div class=\"background background3\"><\/div>\n<div class=\"background background4\"><\/div>\n<div class=\"background background5\"><\/div>\n<div class=\"background background6\"><\/div>\n<\/div>\n<\/div>\n<div class=\"content1\">\n<div class=\"content1-wrapper\">\n<p style=\"text-align: right; margin-top: -50px; margin-right: -50px;\" onclick=\"document.body.classList.remove('active')\"><i class=\"close fa fa-times fa-4x\"><\/i><\/p>\n<div class=\"p-content\">\n<h2 class=\"pop\"><a class=\"news\" href=\"#\">Pathway tracing of prefrontal long-range connections<\/h2>\n<p><\/a><\/p>\n<p>Our focus is on the laminar organization and convergence of long-range limbic, motor and cognitive pathways within the anterior cingulate cortex (ACC), which are implicated in cognitive-emotional integration.<\/p>\n<p><b>Our recent study has found distinct dorsal-motor and ventral-limbic ACC sectors that are integrated by amygdalar inputs (Calderazzo et al., 2021, JCN).<\/b><\/p>\n<p><img src=\"\/anatneuro\/files\/2021\/09\/MLabB1I1.png\" alt=\"\"\/><\/p>\n<p>Calderazzo SM, Busch SE, Moore TL, Rosene DL, Medalla M. (2021) Distribution and overlap of entorhinal, premotor, and amygdalar connections in the monkey anterior cingulate cortex. J Comp Neurol. 2021 Mar;529(4):885-904. doi: 10.1002\/cne.24986. Epub 2020 Aug 13.<\/p>\n<p><b>Single-cell biophysical and apical dendritic properties of ACC pyramidal neurons are layer- and target-dependent (Medalla at al., 2021, Cerebral Cortex, in press).<\/b><\/p>\n<p><img src=\"\/anatneuro\/files\/2021\/09\/MLabB1I2.png\" alt=\"\"\/><\/p>\n<p><img src=\"\/anatneuro\/files\/2021\/09\/MLabB1I3.png\" alt=\"\"\/><\/p>\n<p>Medalla M, Chang W.,  Iba\u00f1ez S., Guillamon-Vivancos T., Nittmann M., Kapitonav A., Busch SE., Moore TL., Rosene DL., Luebke JL (2021). Layer-specific pyramidal neuron properties underlie diverse anterior cingulate cortical motor and limbic networks. Cerebral Cortex, in press<\/p>\n<p><b>We study pathways interlinking the ACC with the LPFC and the amygdala using retrograde tracing, optogenetics and whole-cell patch clamp recording in in vitro slices. We study synaptic connections using electron microscopy<\/b><\/p>\n<p><img src=\"\/anatneuro\/files\/2021\/09\/MLabB1I4.png\" alt=\"\"\/><\/p>\n<p style=\"text-align: center;\" class=\"try-again\" onclick=\"document.body.classList.remove('active')\">Back<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><!-- ___________________Regional and Laminar... Popup___________________ --><\/p>\n<div class=\"popup2\">\n<div class=\"popup-inside2\">\n<div class=\"backgrounds2\">\n<div class=\"background2\"><\/div>\n<div class=\"background2 background22\"><\/div>\n<div class=\"background2 background32\"><\/div>\n<div class=\"background2 background42\"><\/div>\n<div class=\"background2 background52\"><\/div>\n<div class=\"background2 background62\"><\/div>\n<\/div>\n<\/div>\n<div class=\"content2\">\n<div class=\"content2-wrapper\">\n<p style=\"text-align: right; margin-top: -50px; margin-right: -50px;\" onclick=\"document.body.classList.remove('active2')\"><i class=\"close fa fa-times fa-4x\"><\/i><\/p>\n<div class=\"p-content\">\n<h2 class=\"pop\"><a class=\"news\" href=\"#\">Regional and Laminar Specialization of prefrontal Excitatory and Inhibitory microcircuits<\/h2>\n<p><\/a><\/p>\n<p>The laminar organization and diversity of the excitatory and inhibitory microcircuits across primate prefrontal areas are largely unknown. Our work has contributed to an understanding of excitatory and inhibitory synaptic diversity at the single cell level \u2013 leading us one step closer to the elusive goal of identifying how distinct pathways are integrated in single neurons.<\/p>\n<p><b>Our multi-tiered studies using in vitro whole cell, high resolution confocal and electron microscopy and computational model shows that diverse perisomatic inhibitory inputs to ACC and LPFC layer 3 pyramidal neurons confer distinct oscillatory network dynamics in these areas (Medalla et al., 2017 J. Neurosci). <\/b><\/p>\n<p><img src=\"\/anatneuro\/files\/2022\/02\/MlabB2I1.png\" alt=\"\"\/><\/p>\n<p>Medalla M, Gilman JP, Wang JY, Luebke JI. Strength and Diversity of Inhibitory Signaling Differentiates Primate Anterior Cingulate from Lateral Prefrontal Cortex. J Neurosci. 2017 May 3;37(18):4717-4734. doi: 10.1523\/JNEUROSCI.3757-16.2017. Epub 2017 Apr 5.<\/p>\n<p><b>In collaboration with Jennifer Luebke, we have shown that in contrast to the cellular and synaptic diversity across monkey cortical areas, visual and frontal areas in the mouse have largely similar cellular and synaptic features.<\/b><\/p>\n<p><img src=\"\/anatneuro\/files\/2022\/02\/MLabB2I2.png\" alt=\"\"\/><\/p>\n<p>Hsu A, Luebke JI, Medalla M. Comparative ultrastructural features of excitatory synapses in the visual and frontal cortices of the adult mouse and monkey. J Comp Neurol. 2017 Jun 15;525(9):2175-2191. doi: 10.1002\/cne.24196. Epub 2017 Mar 26.<\/p>\n<p>Gilman JP*, Medalla M*, Luebke JI. (2016) Area-Specific Features of Pyramidal Neurons-a Comparative Study in Mouse and Rhesus Monkey. Cereb Cortex. 2016 Mar 10. pii: bhw062. [Epub ahead of print]  PMID: 26965903 *co-first authors<\/p>\n<p>Medalla M and Luebke, JI. (2015) Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey. J Neurosci, 2015 Jan 7; 35(1):112-27. doi: 10.1523\/JNEUROSCI.3426-14.2015. PMID: 25568107 <\/p>\n<p><b>In collaboration with Chand Chandrasekaran, we have begun to bridge the gap of laminar structure, connectivity and dynamics of task-relevant single cell activity in monkeys:<\/b><\/p>\n<p>Lee EK, Balasubramanian H, Tsolias A,  Anakwe SU, Medalla M, Shenoy KV, Chandrasekaran C  (2021). Non-linear dimensionality reduction on extracellular waveforms reveals cell type diversity in premotor cortex. Elife. 2021 Aug 6;10:e67490. doi: 10.7554\/eLife.67490. Online ahead of print.<\/p>\n<p>In collaboration with Dr. Luebke and Chandrasekaran, we will use viral tracing and optogenetics of specific excitatory and inhibitory cell types to further probe these questions.<\/p>\n<p><img src=\"\/anatneuro\/files\/2022\/02\/B2I.jpg\" alt=\"\"\/><\/p>\n<p>In collaboration with Dr. Ella Zeldich, we will use state-of-the-art single-cell RNAseq transcriptomics combined with tract-tracing and in vitro electrophysiological techniques, to determine the molecular signature, neurochemical and functional profile of lamina-specific prefrontal excitatory, and inhibitory neurons that control arousal and stress. The proposed study will unravel the molecular underpinnings of laminar and functional diversity of ACC circuits mediating affective behavior, which has broad therapeutic implications for understanding neurochemical imbalance and susceptibility in stress-related disorders.<\/p>\n<p style=\"text-align: center;\" class=\"try-again\" onclick=\"document.body.classList.remove('active2')\"\">Back<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><!-- ___________________Circuit plasticity... Popup___________________ --><\/p>\n<div class=\"popupC\">\n<div class=\"popup-insideC\">\n<div class=\"backgroundsC\">\n<div class=\"backgroundC\"><\/div>\n<div class=\"backgroundC background2C\"><\/div>\n<div class=\"backgroundC background3C\"><\/div>\n<div class=\"backgroundC background4C\"><\/div>\n<div class=\"backgroundC background5C\"><\/div>\n<div class=\"backgroundC background6C\"><\/div>\n<\/div>\n<\/div>\n<div class=\"contentC\">\n<div class=\"contentC-wrapper\">\n<p style=\"text-align: right; margin-top: -50px; margin-right: -50px;\" onclick=\"document.body.classList.remove('activeC')\"><i class=\"close fa fa-times fa-4x\"><\/i><\/p>\n<div class=\"p-content\">\n<h2 class=\"pop\"><a class=\"news\" href=\"#\">Circuit Plasticity in Aging, Injury, and Neurodegeneration<\/h2>\n<p><\/a><\/p>\n<p>My collaborative work has explored the cellular changes that occur with aging and after injury in the frontal cortex of monkeys, and selective tau neuropathology in medial temporal areas in rodents.<\/p>\n<p>In ongoing projects with Drs. Tara Moore and Douglas Rosene, we have found that injury in motor cortices leads to neuronal hyperexcitability, microglial inflammation, and dysregulation of oligodendrocyte and myelin plasticity. Further, in collaboration with Drs. Ben Buller and Hongqi Xin from Henry Ford, we have shown that these injury-related pathological changes are ameliorated by systemic treatment with extracellular vesicles (EV) derived from bone-marrow stem-cells, acting as immune-modulators that can stimulate neural plasticity after injury.<\/p>\n<p><img src=\"\/anatneuro\/files\/2022\/02\/MLabB3I1.png\" alt=\"\"\/><\/p>\n<p><img src=\"\/anatneuro\/files\/2022\/02\/MLabB3I2.png\" alt=\"\"\/><\/p>\n<p>Medalla M, Chang W, Calderazzo SM, Go V, Tsolias A, Goodliffe JW, Pathak D, De Alba D, Pessina M, Rosene DL, Buller B, Moore TL. (2020) Treatment with Mesenchymal-Derived Extracellular Vesicles Reduces Injury-Related Pathology in Pyramidal Neurons of Monkey Perilesional Ventral Premotor Cortex. J Neurosci. 40(17):3385-3407. doi: 10.1523\/JNEUROSCI.2226-19.2020. Epub 2020 Apr 2.<\/p>\n<p>Go V, Sarikaya D, Zhou Y, Bowley BGE, Pessina MA, Rosene DL, Zhang ZG, Chopp M, Finklestein SP, Medalla M, Buller B, Moore TL. (2020) Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys. Exp Neurol.:113540. doi: 10.1016\/j.expneurol.2020.113540. Online ahead of print.<\/p>\n<p>Go V, Bowley BGE, Pessina MA, Zhang ZG, Chopp M, Finklestein SP, Rosene DL, Medalla M, Buller B, Moore TL. (2020) Extracellular vesicles from mesenchymal stem cells reduce microglial-mediated neuroinflammation after cortical injury in aged Rhesus monkeys. Geroscience. 2020 Feb;42(1):1-17. doi: 10.1007\/s11357-019-00115-w. Epub 2019 Nov 6.<\/p>\n<p>Moore TL, Bowley BGE, Pessina MA, Calderazzo SM, Medalla M, Go V, Zhang ZG, Chopp M, Finklestein S, Harbaugh AG, Rosene DL, Buller B. (2019) Mesenchymal derived exosomes enhance recovery of motor function in a monkey model of cortical injury. Restor Neurol Neurosci. 2019;37(4):347-362. doi: 10.3233\/RNN-190910.<\/p>\n<p><b>My collaborative studies in mice, extend these questions of neuronal survival and degeneration in the context of mouse models of tauopathy. With Dr. Tsuneya Ikezu, we have investigated mechanisms of tau propagation through the entorhinal cortex and hippocampal pathways. With Dr. Ben Wolozin, we have investigated the role of RNA-binding proteins in the neurodegenerative and inflammatory progression of tau pathology within this medial temporal network. These important findings begin to address the question of what allows for some neurons to survive and others to degenerate in disease and injury.<\/b><\/p>\n<p>Ash PEA, Lei S, Shattuck J,  Boudeau S, Carlomagno Y, Medalla M, Mashimo BL, Socorro G, Al-Mohanna LFA, Jiang L, \u00d6zt\u00fcrk MM, Knobel M, Ivanov P, Petrucelli L, S Wegmann S, Kanaan NM, Wolozin B (2021) TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau. Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2014188118. doi: 10.1073\/pnas.2014188118.<\/p>\n<p>Muraoka S, DeLeo AM, Sethi MK, Yukawa-Takamatsu K, Yang Z, Ko J, Hogan JD, Ruan Z, You Y, Wang Y, Medalla M, Ikezu S, Chen M, Xia W, Gorantla S, Gendelman HE, Issadore D, Zaia J, Ikezu T. (2020) Proteomic and biological profiling of extracellular vesicles from Alzheimer&#8217;s disease human brain tissues. Alzheimers Dement. 2020 Jun;16(6):896-907. doi: 10.1002\/alz.12089. Epub 2020 Apr 17.<\/p>\n<p>LeBlang CJ, Medalla M, Nicoletti NW, Hays EC, Zhao J, Shattuck J, Cruz AL, Wolozin B, Luebke JI. (2020). Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy. Front Neurosci. 14:285. doi: 10.3389\/fnins.2020.00285. eCollection 2020.<\/p>\n<p>Asai H, Ikezu S,  Tsunoda S, Medalla M, Luebke JI, Haydar T, Wolozin B, Butovsky O, Ku\u0308gler S &#038;  Ikezu T (2015), Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Oct 5. doi: 10.1038\/nn.4132. [Epub ahead of print]. PMID: 26436904<\/p>\n<p style=\"text-align: center;\" class=\"try-again\" onclick=\"document.body.classList.remove('activeC')\"\">Back<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><!-- ___________________Lab Members___________________ --><\/p>\n<div class=\"blur\">\n<article class=\"content__inner\" style=\"margin-top: 50px;\">\n<h1 class=\"content__title\">Lab Members<\/h1>\n<h3 class=\"content__author\">As of 02\/13\/22<\/h3>\n<\/article>\n<div class=\"row\">\n<div class=\"col-lg-3\">\n<div class=\"property-card\">\n    <a href=\"mailto:mmedalla@bu.edu?subject = Feedback&#038;body = Message\"><\/p>\n<div class=\"property-image\" style=\"background-image:url('\/anatneuro\/files\/2021\/06\/Maya-Medalla-scaled.jpg');\">\n<div class=\"property-image-title\">\n        <\/div>\n<\/p><\/div>\n<p><\/a><\/p>\n<div class=\"property-description\">\n<h5>Maya Medalla, PhD<\/h5>\n<p>PI:  <a href=\"mailto:mmedalla@bu.edu?subject = Feedback&#038;body = Message\">Contact<\/a><\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<div class=\"col-lg-3\">\n<div class=\"property-card\">\n    <a href=\"mailto:jluebke@bu.edu?subject = Feedback&#038;body = Message\"><\/p>\n<div class=\"property-image\" style=\"background-image:url('\/anatneuro\/files\/2016\/08\/luebke1-e1624638935964.jpg');\">\n<div class=\"property-image-title\">\n        <\/div>\n<\/p><\/div>\n<p><\/a><\/p>\n<div class=\"property-description\">\n<h5>Jennifer Luebke, PhD<\/h5>\n<p>PI &#8211; Collaborator:  <a href=\"mailto:jluebke@bu.edu?subject = Feedback&#038;body = Message\">Contact<\/a><\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<div class=\"col-lg-3\">\n<div class=\"property-card\">\n    <a href=\"mailto:lponce@bu.edu?subject = Feedback&#038;body = Message\"><\/p>\n<div class=\"property-image\" style=\"background-image:url('\/anatneuro\/files\/2025\/02\/LorenzPonceimage0.jpeg');\">\n<div class=\"property-image-title\">\n        <\/div>\n<\/p><\/div>\n<p><\/a><\/p>\n<div class=\"property-description\">\n<h5>Lorenze Ponce<\/h5>\n<p>Lab Manager:  <a href=\"mailto:lponce@bu.edu?subject = Feedback&#038;body = Message\">Contact<\/a><\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<div class=\"col-lg-3\">\n<div class=\"property-card\">\n    <a href=\"mailto:marykate@bu.edu?subject = Feedback&#038;body = Message\"><\/p>\n<div class=\"property-image\" style=\"background-image:url('\/anatneuro\/files\/2025\/02\/MKJ-photo.jpg');\">\n<div class=\"property-image-title\">\n        <\/div>\n<\/p><\/div>\n<p><\/a><\/p>\n<div class=\"property-description\">\n<h5>Mary Kate Joyce, PhD<\/h5>\n<p>Post-Doc:  <a href=\"mailto:marykate@bu.edu?subject = Feedback&#038;body = Message\">Contact<\/a><\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<div class=\"col-lg-3\">\n<div class=\"property-card\">\n    <a href=\"mailto:cmojica@bu.edu?subject = Feedback&#038;body = Message\"><\/p>\n<div class=\"property-image\" style=\"background-image:url('\/anatneuro\/files\/2021\/06\/Chrome-Mojica-Lab-Manager-scaled.jpg');\">\n<div class=\"property-image-title\">\n        <\/div>\n<\/p><\/div>\n<p><\/a><\/p>\n<div class=\"property-description\">\n<h5>Chrome Mojica<\/h5>\n<p>PhD Student:  <a href=\"mailto:cmojica@bu.edu?subject = Feedback&#038;body = Message\">Contact<\/a><\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<div class=\"col-lg-3\">\n<div class=\"property-card\">\n    <a href=\"\"><\/p>\n<div class=\"property-image\" style=\"background-image:url('\/anatneuro\/files\/2022\/02\/Benjamin-S.jpg');\">\n<div class=\"property-image-title\">\n        <\/div>\n<\/p><\/div>\n<p><\/a><\/p>\n<div class=\"property-description\">\n<h5>Benjamin Snyder<\/h5>\n<p>MD\/PhD Student<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<div class=\"col-lg-3\">\n<div class=\"property-card\">\n    <a href=\"mailto:zhouybu@bu.edu?subject = Feedback&#038;body = Message\"><\/p>\n<div class=\"property-image\" style=\"background-image:url('\/anatneuro\/files\/2021\/09\/Yuxin-Zhou-Lab-Technician-scaled.jpeg');\">\n<div class=\"property-image-title\">\n        <\/div>\n<\/p><\/div>\n<p><\/a><\/p>\n<div class=\"property-description\">\n<h5>Yuxin Zhou<\/h5>\n<p>PhD Student:  <a href=\"mailto:zhouybu@bu.edu?subject = Feedback&#038;body = Message\">Contact<\/a><\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<div class=\"col-lg-3\">\n<div class=\"property-card\">\n    <a href=\"\"><\/p>\n<div class=\"property-image\" style=\"background-image:url('\/anatneuro\/files\/2023\/08\/bhatt-scaled.jpg');\">\n<div class=\"property-image-title\">\n        <\/div>\n<\/p><\/div>\n<p><\/a><\/p>\n<div class=\"property-description\">\n<h5>Hrishti Bhatt<\/h5>\n<p>PhD Student<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<div class=\"col-lg-4\">\n<div class=\"property-card\">\n    <a href=\"\"><\/p>\n<div class=\"property-image\" style=\"background-image:url('\/anatneuro\/files\/2025\/02\/Angela-Headshot.png');\">\n<div class=\"property-image-title\">\n        <\/div>\n<\/p><\/div>\n<p><\/a><\/p>\n<div class=\"property-description\">\n<h5>Angela Capriglione<\/h5>\n<p>PhD Student<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<div class=\"col-lg-4\">\n<div class=\"property-card\">\n    <a href=\"\"><\/p>\n<div class=\"property-image\" style=\"background-image:url('\/anatneuro\/files\/2025\/02\/Ashley-Headshot.png');\">\n<div class=\"property-image-title\">\n        <\/div>\n<\/p><\/div>\n<p><\/a><\/p>\n<div class=\"property-description\">\n<h5>Ashley Rupert<\/h5>\n<p>MS Student<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<div class=\"col-lg-4\">\n<div class=\"property-card\">\n    <a href=\"\"><\/p>\n<div class=\"property-image\" style=\"background-image:url('\/anatneuro\/files\/2025\/02\/Sonal-PHOTO-2024-09-18-13-25-08.jpg');\">\n<div class=\"property-image-title\">\n        <\/div>\n<\/p><\/div>\n<p><\/a><\/p>\n<div class=\"property-description\">\n<h5>Sonal Khanna, MS<\/h5>\n<p>Bioinformatician<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<\/div>\n<article class=\"content__inner\" style=\"margin-top: 50px;\">\n<h1 class=\"content__title\">Alumni<\/h1>\n<h3 class=\"content__author\">As of 02\/17\/22<\/h3>\n<\/article>\n<div class=\"table-wrapper\">\n<div style=\"height: 300px; overflow: auto;\">\n<table class=\"fl-table\" style=\"padding: 0px; margin: 0px;\">\n<thead>\n<tr>\n<th colspan=\"2\">PhD Students<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"width: 350px;\">Alexandra Tsolias<\/td>\n<td style=\"width: 350px;\">(A&#038;N)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Wayne Chang<\/td>\n<td style=\"width: 350px;\">(A&#038;N)<\/td>\n<\/tr>\n<\/tbody>\n<thead>\n<tr>\n<th colspan=\"2\">Master\u2019s Students and Employees<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"width: 350px;\">Bing Mo<\/td>\n<td style=\"width: 350px;\">(A&#038;N)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Hrishti Bhatt<\/td>\n<td style=\"width: 350px;\">(A&#038;N)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Dickson Chen<\/td>\n<td style=\"width: 350px;\">(A&#038;N)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Junwoo Louis Park<\/td>\n<td style=\"width: 350px;\">(A&#038;N)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Rakin Nasar<\/td>\n<td style=\"width: 350px;\">(A&#038;N)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Mathias Nittmann<\/td>\n<td style=\"width: 350px;\">(MAMs)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Charles Kopp<\/td>\n<td style=\"width: 350px;\">(MAMs)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Samantha Calderazzo<\/td>\n<td style=\"width: 350px;\">(A&#038;N)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Jingyi Wang<\/td>\n<td style=\"width: 350px;\">(A&#038;N)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Joshua Gilman<\/td>\n<td style=\"width: 350px;\">(MAMs)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Silas Busch<\/td>\n<td style=\"width: 350px;\">(lab technician)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Alexander Hsu<\/td>\n<td style=\"width: 350px;\">(MS A&#038;N, &#038; lab technician)<\/td>\n<\/tr>\n<thead>\n<tr>\n<th colspan=\"2\">Undergraduate Research Students<\/th>\n<\/tr>\n<\/thead>\n<tr>\n<td style=\"width: 350px;\">Chantal Aaron<\/td>\n<td style=\"width: 350px;\">(BU PREP student)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Diego DeAlba<\/td>\n<td style=\"width: 350px;\">(STaRs and BU PREP)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Anastasia Kapitonava<\/td>\n<td style=\"width: 350px;\">(UROP, Undergraduate Thesis student)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">James Zhao<\/td>\n<td style=\"width: 350px;\">(UROP)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Heejoo Kang<\/td>\n<td style=\"width: 350px;\">(UROP)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Maxine Hsiung<\/td>\n<td style=\"width: 350px;\">(UROP)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Mitali Sakharkar<\/td>\n<td style=\"width: 350px;\">(UROP)<\/td>\n<\/tr>\n<thead>\n<tr>\n<th colspan=\"2\">Undergraduate Summer Program Students<\/th>\n<\/tr>\n<\/thead>\n<tr>\n<td style=\"width: 350px;\">Shereeen Abdulkabir<\/td>\n<td style=\"width: 350px;\">(BU Prep)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Lazaro Fernandez<\/td>\n<td style=\"width: 350px;\">(StaRs)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Gerardo Sequen Rivera<\/td>\n<td style=\"width: 350px;\">(StaRs)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Mollie Sherman<\/td>\n<td style=\"width: 350px;\">(SPIN)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Caroline Beneville<\/td>\n<td style=\"width: 350px;\">(SPIN)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Haeji Chung,Courtney Dunphy<\/td>\n<td style=\"width: 350px;\">(SPIN)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Joy Yang<\/td>\n<td style=\"width: 350px;\">(SPIN)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Alexandra Morquette<\/td>\n<td style=\"width: 350px;\">(StaRs)<\/td>\n<\/tr>\n<thead>\n<tr>\n<th colspan=\"2\">High School Interns<\/th>\n<\/tr>\n<\/thead>\n<tr>\n<td style=\"width: 350px;\">Marianna Tsolias<\/td>\n<td style=\"width: 350px;\">(2020-2021)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">William Alano<\/td>\n<td style=\"width: 350px;\">(summer 2019)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 350px;\">Adrian Lin<\/td>\n<td style=\"width: 350px;\">(summer 2021)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<div class=\"r-body row\">\n<div class=\"heading\">\n<h1 style=\"color: #ffffff; padding-top: 10vh;\">Recent Publications<\/h1>\n<\/div>\n<div class=\"container22\" style=\"overflow: auto; height: 500px;\">\n<div class=\"list\">\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Medalla M, Chang W.,  Iba\u00f1ez S., Guillamon-Vivancos T., Nittmann M., Kapitonav A., Busch SE., Moore TL., Rosene DL., Luebke JL (2021). Layer-specific pyramidal neuron properties underlie diverse anterior cingulate cortical motor and limbic networks. Cerebral Cortex, in press<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Lee EK, Balasubramanian H, Tsolias A,  Anakwe SU, Medalla M, Shenoy KV, Chandrasekaran C  (2021). Non-linear dimensionality reduction on extracellular waveforms reveals cell type diversity in premotor cortex. Elife. 2021 Aug 6;10:e67490. doi: 10.7554\/eLife.67490. Online ahead of print.<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Ash PEA, Lei S, Shattuck J,  Boudeau S, Carlomagno Y, Medalla M, Mashimo BL, Socorro G, Al-Mohanna LFA, Jiang L, \u00d6zt\u00fcrk MM, Knobel M, Ivanov P, Petrucelli L, S Wegmann S, Kanaan NM, Wolozin B (2021) TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau. Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2014188118. doi: 10.1073\/pnas.2014188118.<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Calderazzo SM, Busch SE, Moore TL, Rosene DL, Medalla M. (2021) Distribution and overlap of entorhinal, premotor, and amygdalar connections in the monkey anterior cingulate cortex. J Comp Neurol. 2021 Mar;529(4):885-904. doi: 10.1002\/cne.24986. Epub 2020 Aug 13.<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Go V, Sarikaya D, Zhou Y, Bowley BGE, Pessina MA, Rosene DL, Zhang ZG, Chopp M, Finklestein SP, Medalla M, Buller B, Moore TL. (2020) Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys. Exp Neurol.:113540. doi: 10.1016\/j.expneurol.2020.113540. Online ahead of print.<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Muraoka S, DeLeo AM, Sethi MK, Yukawa-Takamatsu K, Yang Z, Ko J, Hogan JD, Ruan Z, You Y, Wang Y, Medalla M, Ikezu S, Chen M, Xia W, Gorantla S, Gendelman HE, Issadore D, Zaia J, Ikezu T. (2020) Proteomic and biological profiling of extracellular vesicles from Alzheimer&#8217;s disease human brain tissues. Alzheimers Dement. 2020 Jun;16(6):896-907. doi: 10.1002\/alz.12089. Epub 2020 Apr 17.<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Medalla M, Chang W, Calderazzo SM, Go V, Tsolias A, Goodliffe JW, Pathak D, De Alba D, Pessina M, Rosene DL, Buller B, Moore TL. (2020) Treatment with Mesenchymal-Derived Extracellular Vesicles Reduces Injury-Related Pathology in Pyramidal Neurons of Monkey Perilesional Ventral Premotor Cortex. J Neurosci. 40(17):3385-3407. doi: 10.1523\/JNEUROSCI.2226-19.2020. Epub 2020 Apr 2.<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">LeBlang CJ, Medalla M, Nicoletti NW, Hays EC, Zhao J, Shattuck J, Cruz AL, Wolozin B, Luebke JI. (2020). Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy. Front Neurosci. 14:285. doi: 10.3389\/fnins.2020.00285. eCollection 2020.<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Ikezu S, Yeh H, Delpech JC, Woodbury ME, Van Enoo AA, Ruan Z, Sivakumaran S, You Y,Holland C, Guillamon-Vivancos T, Yoshii-Kitahara A, Botros MB, Madore C, Chao PH, Desani A, Manimaran S, Kalavai SV, Johnson WE, Butovsky O, Medalla M, Luebke JI, Ikezu T. (2020) Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities. Mol Psychiatry. 2020 Feb 18;10.1038\/s41380-020-0671-2. doi: 10.1038\/s41380-020-0671-2. Online ahead of print.<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Go V, Bowley BGE, Pessina MA, Zhang ZG, Chopp M, Finklestein SP, Rosene DL, Medalla M, Buller B, Moore TL. (2020) Extracellular vesicles from mesenchymal stem cells reduce microglial-mediated neuroinflammation after cortical injury in aged Rhesus monkeys. Geroscience. 2020 Feb;42(1):1-17. doi: 10.1007\/s11357-019-00115-w. Epub 2019 Nov 6.<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Moore TL, Bowley BGE, Pessina MA, Calderazzo SM, Medalla M, Go V, Zhang ZG, Chopp M, Finklestein S, Harbaugh AG, Rosene DL, Buller B. (2019) Mesenchymal derived exosomes enhance recovery of motor function in a monkey model of cortical injury. Restor Neurol Neurosci. 2019;37(4):347-362. doi: 10.3233\/RNN-190910.<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Goodliffe JW, Song H, Rubakovic A, Chang W, Medalla M, Weaver CM, Luebke JI. Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+\/- mouse model of Huntington&#8217;s Disease. PLoS One. 2018 Aug 17;13(8):e0200626. doi: 10.1371\/journal.pone.0200626. eCollection 2018.<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Guillamon-Vivancos T, Tyler WA, Medalla M, Chang WW, Okamoto M, Haydar TF, Luebke JI. Distinct Neocortical Progenitor Lineages Fine-tune Neuronal Diversity in a Layer-specific Manner. Cereb Cortex. 2018 Feb 03.<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nat Neurosci. 2018 Jan;21(1):72-80. doi: 10.1038\/s41593-017-0022-z. Epub 2017 Nov 20.<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Medalla M, Gilman JP, Wang JY, Luebke JI. Strength and Diversity of Inhibitory Signaling Differentiates Primate Anterior Cingulate from Lateral Prefrontal Cortex. J Neurosci. 2017 May 3;37(18):4717-4734. doi: 10.1523\/JNEUROSCI.3757-16.2017. Epub 2017 Apr 5.<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Hsu A, Luebke JI, Medalla M. Comparative ultrastructural features of excitatory synapses in the visual and frontal cortices of the adult mouse and monkey. J Comp Neurol. 2017 Jun 15;525(9):2175-2191. doi: 10.1002\/cne.24196. Epub 2017 Mar 26.<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Hilgetag CC, Medalla M, Beul S, and Barbas H (2016) The primate connectome in context: Principles of connections of the cortical visual system. Neuroimage 2016 Apr 12. pii: S1053-8119(16)30050-7. doi: 10.1016\/j.neuroimage.2016.04.017. [Epub ahead of print]. PMID: 27083526<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Gilman JP*, Medalla M*, Luebke JI. (2016) Area-Specific Features of Pyramidal Neurons-a Comparative Study in Mouse and Rhesus Monkey. Cereb Cortex. 2016 Mar 10. pii: bhw062. [Epub ahead of print]  PMID: 26965903 *co-first authors<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Asai H, Ikezu S,  Tsunoda S, Medalla M, Luebke JI, Haydar T, Wolozin B, Butovsky O, Ku\u0308gler S &#038;  Ikezu T (2015), Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Oct 5. doi: 10.1038\/nn.4132. [Epub ahead of print]. PMID: 26436904<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Tyler B, Medalla M, Guillamon-Vivancos T, Luebke J and Haydar T. (2015) Distinct iPC lines give rise to different populations of layer 2\/3 pyramidal cells in the mouse neocortex. J Neurosci. 2015 Apr 15;35(15):6142-52. doi: 10.1523\/JNEUROSCI.0335-15.2015. PMID: 25878286<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Medalla M and Luebke, JI. (2015) Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey. J Neurosci, 2015 Jan 7; 35(1):112-27. doi: 10.1523\/JNEUROSCI.3426-14.2015. PMID: 25568107 <\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Medalla M, Barbas H. (2014) Specialized prefrontal &#8220;auditory fields&#8221;: organization of primate prefrontal-temporal pathways. Front Neurosci. 2014 Apr 16;8:77. doi: 10.3389\/fnins.2014.00077. eCollection 2014. Review. PMID: 24795553<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Luebke JI, Medalla M, Amatrudo JM, Weaver CM, Crimins JL, Hunt B, Hof PR, Peters A. (2013) Age-Related Changes to Layer 3 Pyramidal Cells in the Rhesus Monkey Visual Cortex. Cereb Cortex. 2013 Dec 8. [Epub ahead of print]. PMID: 24323499<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Barbas H, Bunce JG, and Medalla M. (2012) Prefrontal pathways that control attention. Review Chapter. In: Stuss, DT, Knight RT, editors. Principles of Frontal Lobe Development, Second Edition. <\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Medalla M and Barbas H. (2012) The anterior cingulate cortex may enhance inhibition of lateral prefrontal cortex via m2 cholinergic receptors at dual synaptic sites. J Neurosci. 2012 Oct 31; 32(44):15611-25. PMID: 23115196<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Medalla M and Barbas H. (2010) Anterior cingulate synapses in prefrontal areas 10 and 46 suggest differential influence in cognitive control. J Neurosci. 30(48):16068-81. PMID: 21123554<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Medalla M and Barbas H. (2009) Synapses with inhibitory neurons of cortex associated with working memory differentiate anterior cingulate from dorsolateral prefrontal pathways. Neuron 61: 609-20. PMID: 19249280<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Medalla M, Lera P, Feinberg M, Barbas H. (2007) Specificity in inhibitory systems associated with prefrontal pathways to temporal cortex in primates. Cereb Cortex 17 Suppl 1: i136-i150. PMID: 17725996<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Medalla M and Barbas H. (2006) Diversity of laminar connections linking periarcuate and lateral  intraparietal areas depends on cortical structure. Eur J Neurosci 23: 161-179. PMID: 16420426<\/h3>\n<p>    <\/a><\/div>\n<div class=\"num\"><a href=\"\"><\/p>\n<h3 style=\"font-weight: normal; text-indent: -4em; margin-left: 4em;\">Barbas H, Medalla M, Alade O, Suski J, Zikopoulos B, Lera P. (2005) Relationship of prefrontal connections to inhibitory systems in superior temporal areas in the rhesus monkey. Cereb Cortex 15: 1356-1370. PMID:15635060<\/h3>\n<p>    <\/a><\/div>\n<\/p><\/div>\n<\/div>\n<\/div>\n<div class=\"row\">\n<div class=\"col-md-5\">\n<div id=\"tv\">\n<div class=\"universal-padding\">\n<h2 class=\"tv-title\">Contact Us<\/h2>\n<p class=\"contacts\">Medalla Lab<\/p>\n<p class=\"contacts\">650 Albany Street, X306<\/p>\n<p class=\"contacts\">Boston Massachusetts, 02118<\/p>\n<p class=\"contacts\">Office Phone: 617-358-7717<\/p>\n<p class=\"contacts\">Main Lab Phone: 617-358-7721<\/p>\n<p class=\"contacts\">EM Lab: R1010<\/p>\n<p class=\"contacts\">Email: mmedalla@bu.edu<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"col-md-7\">\n<img loading=\"lazy\" src=\"\/anatneuro\/files\/2021\/06\/Luebke-Medalla-Lab-copy.png\" width=\"622\" height=\"350\" class=\"info-img\">\n<\/div>\n<\/div>\n<\/div>\n<p><!-- ___________________Page CSS___________________ --><\/p>\n<style>\n<p>html, body {\n    width: 100%;\n    height: 100%;<\/p>\n<p>}<\/p>\n<p>.main1 {\n  margin: auto;\n  position: absolute;\n  padding: 10px 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.num:nth-child(23):before {\n  content: '';\n  font-size: 4rem;\n  font-weight: normal;\n  color: #000;\n  width: 2rem;\n  opacity: 0.05;\n  transition: 0.25s;\n}<\/p>\n<p>.container22 .list .num:nth-child(24):before {\n  content: '';\n  font-size: 4rem;\n  font-weight: normal;\n  color: #000;\n  width: 2rem;\n  opacity: 0.05;\n  transition: 0.25s;\n}<\/p>\n<p>.container22 .list .num:nth-child(25):before {\n  content: '';\n  font-size: 4rem;\n  font-weight: normal;\n  color: #000;\n  width: 2rem;\n  opacity: 0.05;\n  transition: 0.25s;\n}<\/p>\n<p>.container22 .list .num:nth-child(26):before {\n  content: '';\n  font-size: 4rem;\n  font-weight: normal;\n  color: #000;\n  width: 2rem;\n  opacity: 0.05;\n  transition: 0.25s;\n}<\/p>\n<p>.container22 .list .num:nth-child(27):before {\n  content: '';\n  font-size: 4rem;\n  font-weight: normal;\n  color: #000;\n  width: 2rem;\n  opacity: 0.05;\n  transition: 0.25s;\n}<\/p>\n<p>.container22 .list .num:nth-child(28):before {\n  content: '';\n 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cortex (ACC) \u2013 key areas of the prefrontal \u201cexecutive\u201d network. Given [&hellip;]<\/p>\n","protected":false},"author":18550,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"page-templates\/no-sidebars.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/10578"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/users\/18550"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/comments?post=10578"}],"version-history":[{"count":50,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/10578\/revisions"}],"predecessor-version":[{"id":12662,"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/pages\/10578\/revisions\/12662"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/anatneuro\/wp-json\/wp\/v2\/media?parent=10578"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}