Interdisciplinary Team Receives Grant to Investigate Dialysis Access Malfunction


September 26th, 2018

The research team (from left): Drs. Alik Farber, co-PI, Surgery; Mostafa Belghasem, Pathology; Vipul Chitalia, PD/PI, Medicine; Raj Viveldhan, co-PI, Surgery; and Jean Francis, Medicine. Not pictured is Thomas Szabo, PhD, Biomedical Engineering, BU School of Engineering.

Patients with chronic kidney disease frequently develop stenosis of their intrathoracic large veins (i.e., central venous stenosis), which jeopardizes their prospects of having a functional dialysis access. The current method to diagnose this complication is fraught with inaccuracies.

An interdisciplinary team (members of the Evans Center IBR Thrombosis and Hemostasis ARC) at Boston University has received a major grant from the biotech company Philips to tackle this challenge. The group will lead a clinical study to assess the potential of intravenous ultrasound (IVUS), an emerging technique, to investigate and diagnose the mechanical properties of central venous stenosis.

The results from this study will address one of the critical bottlenecks in the management of dialysis access malfunction, particularly in BMC’s underserved patient population. It is also likely to seed larger clinical trials in the future to guide endovascular therapies.

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