Bone Injury and Repair
The Bone Injury and Repair component of the Center for Regenerative Medicine is housed within the Orthopaedic Research Laboratory at Boston University. This program focuses on advancing our understanding of the basic mechanisms and stem cell populations involved in effective bone healing after fracture or injury. Both during embryonic development as well as following injury, bone formation and remodeling is a highly dynamic process involving a variety of cell lineages, including at least two stem cell populations: mesenchymal stem cells and hematopoietic stem cells. Investigators in our program have contributed seminal publications describing the genetic program of fracture repair and are currently focused on identifying the stem cell populations involved in regulating this complex genetic program. Mouse models of bone healing are employed to investigate the basic science of bone repair in vivo, and scientists, physician-scientists, and clinicians collaborate to develop novel therapies that enhance bone healing after injury and regeneration of lost bone after trauma.
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