CReM researchers have been awarded an RC2 GO grant to derive differentiated endodermal and hematopoietic lineages from human iPS cells.
The multicenter study, lead by Boston University Principal Investigators, Drs. Darrell Kotton and Gustavo Mostoslavsky, applies reprogramming technology to derive human iPS cells and then characterize their differentiated progeny using bioinformatics approaches.

Millipore Licenses Novel Stem Cell Technology from Boston University

Provides highly efficient method for creating induced pluripotent stem cells

Millipore has licensed the CReM’s STEMCCA single lentiviral vector for reprogramming somatic cells into induced pluripotent stem (iPS) cells. Please click here to read the press release and learn more.

On-line summaries of the latest publications this year from CReM investigators:

Cardoso Lab on journal cover

• Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. Eminli, S., Foudi, A., Stadtfeld, M., Maherali, N., Ahfeldt, T. Mostoslavsky, G., Hock, H., Hochedlinger, K. Nature Genetics. 2009. Epub August 9 doi:10.1038/ng.428. PMID: 19668214 [PubMed - as supplied by publisher]
• Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes. Bais M, McLean J, Sebastiani P, Young M, Wigner N, Smith T, Kotton DN, Einhorn TA, Gerstenfeld LC. PLoS One. 2009;4(5):e5393. Epub 2009 May 5.PMID: 19415118 [PubMed - indexed for MEDLINE]

• Notch signaling controls the balance of ciliated and secretory cell fates in developing airways. Tsao PN, Vasconcelos M, Izvolsky KI, Qian J, Lu J, Cardoso WV. Development. 2009 Jul;136(13):2297-307. PMID: 19502490 [PubMed - in process]

• Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Sommer CA, Stadtfeld M, Murphy GJ, Hochedlinger K, Kotton DN, Mostoslavsky G. Stem Cells. 2009 Mar;27(3):543-9. PMID: 19096035 [PubMed - in process]

• Breathing life into the lung stem cell field. Fine A. Cell Stem Cell. 2009 Jun 5;4(6):468-9. PMID: 19497272 [PubMed - in process]

Mouse iPS Cell Colonies