Scientific Program
Saturday, August 3
| 1-5pm |
Registration/Poster Set-up |
Sunday, August 4
| 8am-5pm |
Registration |
| 8:15am |
Welcome and Introduction – Carol Black and Robert Lafyatis |
Session 1 – Integrative Medicine
| 8:25am |
Introduction |
| 8:30 |
The application of bioinformatics to autoimmune disease – Atul Butte |
| 9:30 |
The genetic basis for tsk2 – Elizabeth Blankenhorn |
| 10:00 |
Discussion |
| 10:30 |
COFFEE BREAK |
Session 2 – Biomarkers
| 10:55 |
Introduction |
| 11:00 |
Biomarkers of interstitial lung disease – Naftali Kaminski |
| 11:30 |
Alterations in angiogenesis in systemic sclerosis – Marco Matucci Cerinic |
| 12:00pm |
Discussion |
| 12:30 |
LUNCH |
Session 3 – ER Stress
| 1:55 |
Introduction |
| 2:00 |
Unfolded protein response and oxidative stress – Randal Kaufman |
| 2:30 |
Oxidative and mechanical stress in pulmonary fibrosis – Victor Thannickal |
| 3:00 |
Discussion |
| 3:30 |
TEA BREAK |
Session 4 – Environmental & Infectious Disease Triggers
| 3:55 |
Introduction |
| 4:00 |
Identifying environmental factors in autoimmune diseases – Fred Miller |
| 4:30 |
Microbial pathogens in skin disease – Sarah Arron |
| 5:00 |
Discussion |
| 5:30 |
END of SESSION |
| 5:45 |
WELCOME RECEPTION – AGGANIS ARENA |
Monday, August 5
Session 5 – Molecular Genetics and Fibrosis
| 7:55am |
Introduction |
| 8:00 |
Non-coding RNAs in skin – Howard Chang |
| 8:30 |
Epigenetics and liver fibrosis – Derek Mann |
| 9:00 |
Discussion |
Session 6 – High Throughput Proteomics
| 9:15 |
Introduction |
| 9:20 |
Systems-level analysis of proteolytic events in increased vascular permeability
and complement activation in skin inflammation- Chris Overall |
| 9:50 |
Biomarker studies in lupus nephritis – Chandra Mohan |
| 10:20 |
Discussion |
| 10:35 |
COFFEE BREAK |
Session 7 – Matrisomal Proteins and Adipose in Fibrosis
| 10:55 |
Introduction |
| 11:00 |
Decoding the matrix – Richard Hynes |
| 11:30 |
Advance in understanding adipogenesis and links to fibrosis – Stephen Farmer |
| 12:00pm |
Discussion |
| 12:15 |
LUNCH |
Session 8 – Angiogenesis & Pericytes
| 1:25 |
Introduction |
| 1:30 |
Pericytes – Annika Keller |
| 2:00 |
Mesenchymal cells and pericytes in lymph node architecture – Theresa Lu |
| 2:30 |
Pericytes in injury and fibrosis – Lucie Peduto |
| 3:00 |
Discussion |
| 3:15 |
TEA BREAK |
Session 9 – Vascular Disease – Applications to Scleroderma
| 3:40 |
Introduction |
| 3:45 |
Pathophysiology of giant cell arteritis – Cornelia Weyand |
| 4:00 |
Vascular capillary leak in systemic sclerosis – Tracy Frech |
| 4:15 |
Biomarkers of vasculitis – Paul Monach |
| 4:30 |
Discussion |
| 5:00 |
END of SESSION |
Tuesday, August 6
Session 10 -Breakthroughs in Therapy
| 7:55am |
Introduction |
| 8am |
Autologous hematopoietic stem cell treatment of scleroderma
– lessons learned over 15 years - Alan Tyndall |
Session 11 – PAH & Vascular Remodeling
| 8:40am |
Introduction |
| 8:45 |
Cell therapy approaches for pulmonary arterial hypertension – Duncan Stewart |
| 9:15 |
Inflammation and hypoxia in pulmonary arterial hypertension – Kurt Stenmark |
| 9:45 |
Discussion |
| 10:15 |
COFFEE BREAK |
Session 12 – Industry Presentations
| 10:40 |
Introduction |
| 10:45 |
Evaluation of the anti-fibrotic properties of CCNs in pulmonary fibrosis -
R Lemaire – Medimmune |
| 11:00 |
TLR blockade in autoimmune disease – T Sullivan/R Arbeit – Idera |
| 11:15 |
Mesenchymal stem cells as therapeutics – Celltex |
| 11:30 |
Dasatinib in systemic sclerosis – B Ganguly – Bristol Myers Squibb |
| 11:45 |
TBA – R Marshall – GlaxoSmithKline |
| 12:00pm |
Molecular diagnostics for systemic sclerosis: Towards
personalized medicine – Y Nesbeth – Celdara |
| 12:15 |
LUNCH |
Session 13 – Selected Abstract Presentations
| 1:40 |
Introduction |
|
| 1:45 |
TBA |
|
| 2:00 |
TBA |
|
| 2:15 |
TBA |
|
| 2:30 |
TBA |
|
| 2:45 |
TBA |
|
3 – 5 pm – Poster Viewing ~ 18th Floor Lounge ~ 10 Buick Street
6pm – BANQUET – Metcalf Trustee Center Ballroom ~ One Silber Way ~ 9th Floor
Banquet Speaker: Joseph Loscalzo, MD, PhD, Chairman, Department of Medicine; Physician-in-Chief; Brigham and Women’s Hospital; Hersey Professor of the Theory and Practice of Medicine, Harvard Medical School
Wednesday, August 7
Session 14 – Innate Inflammation in Fibrosis I
| 7:55am |
Introduction |
| 8:00 |
The inflammasome in interstitial lung disease – Augustine Choi |
| 8:30 |
Lipid mediators in inflammation and fibrosis – Charles Serhan |
Session 15 – Innate Inflammation in Fibrosis II
| 9:00 |
Sterile injury and inflammation – Richard Flavell |
| 9:30 |
Inflammasomes in systemic sclerosis – Carol Artlett |
| 10:00 |
Discussion |
| 10:30 |
COFFEE BREAK |
Session 16 – Monocytes/Macrophages in Fibrotic Disease
| 10:55 |
Introduction |
| 11:00 |
Macrophage heterogeneity and alternative activation – Siamon Gordon |
| 11:30 |
Macrophage activation in fibrosis – Tom Wynn |
| 12:00pm |
Discussion |
| 12:30 |
LUNCH |
Session 17 – Scleroderma Clinical Trials Consortium
| 1:55 |
Introduction |
|
| 2:00 |
TBA |
|
| 2:30 |
TBA |
|
| 3:00 |
TBA |
|
| 3:30 |
TBA |
|
END of WORKSHOP
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