Current Studies
| TITLE | INDICATION | PI | SPONSOR | COORDINATOR |
| “SCOT study” – Randomized, Open-Label, Phase 11/111 Multi-Center Study of High Dose Immunosuppressive Therapy Using Total Body Irradiation, Cyclophosphamide, ATGAM, and Autologous Transplantation with Auto-CD34+HPC Versus Intravenous Pulse Cyclophosphamide for the Treatment of Severe Systemic Sclerosis | Diffuse Scleroderma | Simms | DAIT/NAID/NIH & Duke University | Kim Tobin 617-638-7503 kimtobin@bu.edu |
| “COMPASS study” – Effects of Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Morbidity and Mortality in Symptomatic Patients with Pulmonary Arterial Hypertension | Pulmonary Hypertension | Farber | Actelion | Kim Tobin 617-638-7503 kimtobin@bu.edu |
| “REVEAL Registry” – Registry to Evaluate Early and Long-term PAH Disease Management | Pulmonary Hypertension | Farber | Actelion | Kim Tobin 617-638-7503 kimtobin@bu.edu |
| “PHAROS Registry” – The Natural History and Outcome of Scleroderma Patients at High Risk or with early Pulmonary Hypertension | At Risk or Early Pulmonary Hypertension | Simms | Georgetown University | Kim Tobin 617-638-7503 kimtobin@bu.edu |
| Multicenter Phase II Trial of Oral Type I Bovine Collagen in Scleroderma – Subproject “HLA Typing and DNA Repository” | Scleroderma – study extension | Merkel | University of Tennessee/NIH | Kim Tobin 617-638-7503 kimtobin@bu.edu |
| RAVE Study; Rituximab for ANCA-Associated Vasculitis. A multicenter phase II/III, double-blind, placebo-controlled study of Rituximab therapy in Wegner’s Granulomatosis and Microscopic Polyangiitis. | ANCA-Associated Vasculitis | Merkel | NIAID/Immune Tolerance Network | Manuella Clark-Cotton mrcc@bu.edu |
| Rapids 2 Long term bosentan open label extension of Rapids-2 study in SSc patients with ischemic DU. | Ischemic Digital Ulcers | Merkel | Actelion | Fei-Ying Cheong fycheon@bu.edu |
| Rapids 2 OL A Long-Term, Open-Label Study to Evaluate the Safety of Sitaxsentan Sodium Treatment in Patients with Pulmonary Arterial Hypertension |
Pulmonary Arterial Hypertension | Simms | Encysive | Fei-Ying Cheong fycheon@bu.edu |
| Rituximab Treatment of Scleroderma, An Open Label, Phase 1 Study. | Lafyatis | Genentech | Fei-Ying Cheong fycheon@bu.edu | |
| MQX OL Phase III Open Label Study of a Topical Gel Formulation of Nitroglycerin, MQX-503 in the Treatment and Prevention of Raynaud’s phenomenon | Raynaud’s | Simms | Mediquest | Fei-Ying Cheong fycheon@bu.edu |
| Cellcept Mycophenolate Mofetil in Systemic Sclerosis | Lafyatis | Cellcept | Fei-Ying Cheong fycheon@bu.edu | |
| LGVY A Randomized, Double Blind Placebo-Controlled, Phase 3 study of the Phosphodiesterase Type 5 Inhibitor Tadalafil in the Treatment of Patients with Pulmonary Arterial Hypertension | Pulmonary Arterial Hypertension | Farber | ICOS/Lilly | Fei-Ying Cheong fycheon@bu.edu |
| LGVX A Double Blind, Extension Study to Evaluate the Long Term Safety and Efficacy of the Phosphodiesterase Type 5 Inhibitor Tadalafil in the Treatment of Patients with Pulonary Hypertension. | Pulmonary Arterial Hypertension | Farber | ICOS/Lilly | Fei-Ying Cheong fycheon@bu.edu |
| Vasculitis Clinical Research Consortium Study of Wegener’s Granulomatosis and Microscopic Polyangiitis | Merkel | Rare Diseases Clinical Research Network | Jess Martin jmartin@bu.edu |
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| Vasculitis Clinical Research Consortium Study of Takayasu’s Arteritis | Merkel | Rare Diseases Clinical Research Network | Jess Martin jmartin@bu.edu |
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| Vasculitis Clinical Research Consortium Study of Churg-Strauss Syndrome | Merkel | Rare Diseases Clinical Research Network | Jess Martin jmartin@bu.edu |
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| Vasculitis Clinical Research Consortium Study of Giant Cell Arteritis | Merkel | Rare Diseases Clinical Research Network | Jess Martin jmartin@bu.edu | |
| Vasculitis Clinical Research Consortium Study of Polyarteritis Nodosa | Merkel | Rare Diseases Clinical Research Network | Jess Martin jmartin@bu.edu |
| Multi-Center, Open-Label Pilot Study of Abatacept in the Treatment of Mild Relapsing Wegener’s Granulomatosis (WG) | Merkel | NIH | Manuella Clark-Cotton |
| Concurrent Pilot Studies in Giant Cell Arteritis and Takayasu’s Arteritis to Examine the Safety, Efficacy, and Immunologic Effects of Abatacept in Large Vessel Vasculitis | Merkel | NIAMS | Manuella Clark-Cotton |
| Imaging Protocol for MRI and PET/CT in Takayasu’s Arteritis: Development as Clinical Trial Outcome Measures | Merkel | NIH | Jess Martin jmartin@bu.edu |
| Healthy Control Blood Samples for use in Research into Autoimmune/ Inflammatory Diseases | Merkel | Sharleen Johnson |
