Boston University Medical Campus
Pulmonary, Critical Care, and Allergy Medicine

Special Interests:

RESEARCH:

• Appraisal of the medical literature
• Methodology of clinical practice guidelines
• Evidence-based medicine
• Writing and grading evidence-based recommendations
• Presentation of the evidence
• Development of resources to advance clinical knowledge.

CLINICAL:

• Critical Care Medicine
• General Pulmonary Medicine

Dr. Wilson attends in the Medical Intensive Care Unit and on the Pulmonary Consultation Service at Boston Medical Center.

Dr. Wilson is a clinical practice guideline methodologist who has expertise in appraising the literature, presenting the evidence, and writing and grading evidence-based recommendations. He serves as a Deputy Editor of Pulmonary, Critical Care, and Sleep Medicine at UpToDate®, an electronic clinical resource for physicians. As deputy editor, he writes concise reviews of topics related to Pulmonary, Critical Care, and Sleep Medicine, reviews the medical literature daily, and updates each topic with the latest medical evidence. For each topic, Dr. Wilson formulates evidence-based recommendations and grades each recommendation to reflect the quality of evidence supporting the recommendation.

Dr. Wilson has also served as the methodologist for clinical practice guideline panels for various organizations and teaches about how to critically appraise the literature and apply the evidence to clinical practice. As a result of his work, Dr. Wilson received the 2009 Clinical Teaching Award, is listed in “America’s Top Physicians”, and was recognized as a “Clinical Expert” at the 2007 American Thoracic Society International Conference.

Selected Publications:

ARTICLES:

1. Wilson KC, Irwin R, File T, Guyatt GH, Schunemann HJ, Rabe K. Reporting and publishing guidelines. Proc Am Thorac Soc 2009; In press.
2. Guyatt GH, Oxman A, Wilson KC, Wilt T, Antman E, Akl E, Gutterman D, Puhan M, Schunemann HJ. Synthesis, grading, and presentation of evidence in guidelines. Proc Am Thorac Soc 2009; In press.
3. Wilson KC. Grading improves transparency and quality. CHEST 2008; In press.
4. Wilson KC and Farber HW. Propylene glycol accumulation during continuous intravenous lorazepam infusion in critically ill patients. J Intensive Care Med 2008; 23:413.
5. Wilson KC, Hollingsworth, H. What’s New in Pulmonary, Critical Care Medicine, and Sleep Medicine. In: UpToDate, Rose, BD, UpToDate, Waltham, MA, October 2007, March 2008, and July 2008.
6. Wilson KC. What’s New in Pulmonary, Critical Care Medicine, and Sleep Medicine. In: UpToDate, Rose, BD, UpToDate, Waltham, MA, February 2007 and June 2007.
7. Fisher KA, Serlin DM, Wilson KC, et al. Sarcoidosis-associated pulmonary hypertension: outcome with long-term epoprostenol treatment. Chest 2006; 130:1481.
8. Wilson KC. What’s New in Pulmonary and Critical Care Medicine. In: UpToDate, Rose, BD, UpToDate, Waltham, MA, February 2006, June 2006, and October 2006.
9. Wilson KC, Reardon C, Theodore AC, and Farber HW. Propylene glycol toxicity is a potentially life-threatening iatrogenic illness and a common cause of metabolic abnormality in MICU patients receiving intravenous benzodiazepines. CHEST. 2005; 128(3): 1674.
10. Wilson KC, Cattell D, Wan Z, Rahangdale S, Sullivan BA, Cruikshank WW, and Center DM. Regulation of nuclear Prointerleukin-16 and p27Kip1 in primary human T lymphocytes. Cell Immunol 2005; 237:17-27.
11. Wilson KC and Saukkonen JJ. Acute respiratory failure from abused substances. J Intensive Care Med 2004; 19: 183-93.
12. Wilson KC, Center DM, and Cruikshank WW.The Effect of Interleukin-16 and its Precursor on T Lymphocyte Activation and Growth. Growth Factors 2004; 22: 97-104.
13. Lynch EL, Little FF, Wilson KC, Center DM, and Cruikshank WW. Immunomodulatory cytokines in asthmatic inflammation. Cytokine Growth Factor Rev 2003; 14: 489-502.
14. Wilson KC, Center DM, Cruikshank WW, and Zhang Y. Binding of HTLV-1 Tax oncoprotein to the precursor of Interleukin-16, a Tcell PDZ Domain containing protein. Virology 2003; 306: 60-67.
15. Wilson KC, Cruikshank WW, Center DM, and Zhang Y. The N-terminal domain of prointerleukin-16 contains a functional CcN motif. Biochemistry 2002; 41: 14306-12.
16. Wilson KC, Bielska B, and Farber HW. Mycobacterium marinum osteomyelitis. Orthopedics 2002; 26: 332-333.
17. Wilson KC, Guardino J, and Shapira OM. Pulmonary embolism as a presenting feature of cavo-atrial hepatocellular carcinoma. CHEST 2000; 116: 657-658.
18. Wilson KC, Reardon C, and Farber HW. Propylene glycol toxicity from intravenous diazepam. New Engl J Med 2000; 343: 815.
19. Wilson KC. The reflex action: a contribution of physiology to neurology. The Pharos; 1996; 59:34-36.
20. Wilson KC. Discovery of blood circulation and the subsequent creation of the scientific method. The Pharos 1994; 57:33-35.
21. Wilson KC and Finbloom DS. Interferon-gamma rapidly induces in human monocytes a novel DNA-binding factor that recognizes the gamma response region within the promoter of the gene for the high affinity Fc-gamma receptor. Proc Natl Acad Sci USA 1992; 89: 11964-11968

CHAPTERS:

1. Wilson KC. Smoke and carbon monoxide inhalation. In, The Intensive Care Unit Manual, 2nd Edition (Eds, Lanken PN, Hanson CW, and Manaker S). Elsevier, St. Louis, MO. 2010. In press.
2. Wilson KC , Mirabile-Levens E, and Saukkonen JJ. Pulmonary complications of addictive and abused substances. In, “Principles of Addiction Medicine, 4th Edition”. (Eds., Graham AW and Schultz TK). In press.
3. Little FF, Wilson KC , Berman JS, and Center DM. Lymphocyte- and macrophage-mediated inflammation in the lung. In, “Fishman’s Pulmonary Diseases and Disorders, 4th Edition”. (Eds. Fishman AP, Elias JA, Fishman JA, Grippi MA, Senior RM, and Pack AI). McGraw-Hill , New York , 2008. Pp.291-306.
4. Wilson KC , Cruikshank WW, and Center DM. The Role of Chemokines in Lymphocyte Trafficking to Lymph Nodes of the Lung. In, “Chemokines of the Lung”. (Eds., Strieter R, Standiford T, Lefant C). Lung Biology in Health and Disease series. Marcel Dekker, Inc, New York , 2003. pp 47-64.
5. Wilson KC , Center DM, and Cruikshank WW. Interleukin-16. In, “The Cytokine Handbook, 4th Edition.” (Eds., Thomson A. and Lotze M.). Academic Press, San Diego , 2003. pp 463-472.
6. Wilson KC , Cruikshank WW, and Center DM. Interleukin-16. In, “Encyclopedia of Hormones”. (Eds., Henry HL and Norman AW.). Academic Press, San Diego , 2003. pp 1-9.
7. Mirabile-Levens E, Wilson KC , and Saukkonen JJ. Pulmonary complications of addictive and abused substances. In, “Principles of Addiction Medicine, 3rd Edition”. (Eds., Graham AW and Schultz TK), American Society of Addiction Medicine, Chevy Chase , MD , 2003.pp 1123-1145.

Links:

www.UpToDate.com
www.gradeworkinggroup.org