Katrina Steiling, MD, MSc
Faculty and Fellows
Assistant Professor of Medicine
Medical School: Boston University School of Medicine
Internship: Boston University Medical Center
Residency: Boston University Medical Center
Fellowship: Boston University Medical Center
Master’s/PhD programs: Masters of Science in Bioinformatics, College of Engineering, Boston University
- Airway gene expression
- Chronic Obstructive Pulmonary Disease (COPD)
- Lung Cancer
- Thoracic Oncology
- Pulmonary Medicine
- Critical Care Medicine
Dr. Steiling is a Pulmonary/Critical Care Physician-Scientist with a longstanding interest in improving the ability to effectively detect, treat, and cure smoking-induced lung diseases such as lung cancer and chronic obstructive pulmonary disease (COPD). She completed her fellowship training in Pulmonary and Critical Care Medicine at Boston University Medical Center, and concurrently completed a Master of Science in Bioinformatics through the Boston University College of Engineering.
Dr. Steiling’s research centers on improving the diagnosis, treatment and prevention of lung cancer and COPD. Using the airway field of injury hypothesis, which posits that cigarette smoking induces molecular changes throughout the respiratory tract, she has studied alterations in the airway transcriptome that reflect the presence, susceptibility, and progression of smoking-induced lung diseases. She has used whole-genome expression profiling of the bronchial airway epithelium to describe the relationship between upper and lower airway gene expression, and leveraged this information to develop clinically-relevant biomarkers of lung cancer, COPD, and other diseases that affect the lung.
In addition to her translational research, Dr. Steiling has led the implementation of two important clinical programs focused on improving the early detection of lung cancer in at-risk individuals. She founded the Boston Medical Center Lung Nodule Clinic, a sub-specialty referral resource that supports the evidence-based evaluation of incidental pulmonary nodules detected by diagnostic and screening CT scans. She also led the implementation of a multi-disciplinary Lung Cancer Screening Program at Boston Medical Center. Her team was recognized with a 2016 Clinical Quality Improvement Award from the Boston University Medical Center Evans Foundation. She currently co-chairs the Boston Medical Center Lung Cancer Screening Steering Committee.
Dr. Steiling sees patients in the Lung Nodule Clinic, multi-disciplinary Thoracic Oncology Clinic and attends in the Medical Intensive Care Unit at Boston Medical Center.
Hersch CP, Adcock IM, Celedon JC, Cho MH, Christiani DC, Himes BE, Kaminski N, Mathias RA, Meyers DA, Quackenbush J, Redline S,Steiling KA, Tabor HK, Tobin MD, Wurfel MM, Yang IV, Koppelman GH. “High Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research: An Official American Thoracic Society Workshop Report.” Ann Am Thorac Soc, 2019;16(1):1-16. PMID: 30592451
Faiz A, Steiling K, Roffel MP, Postma DS, Spira A, Lenburg ME, Borggrewe M, Eijgenraam TR, Jonker MR, Koppleman GH, Pouwels SD, Liu G, Alekseyev YO, Lam S, Hiemstra PS, Sterk PJ, Timens W, Brandsma CA, Heijink IH, van den Berge M. “Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in Chronic Obstructive Pulmonary Disease.” Eur Resp J, 2019; 53(4). PMID: 30846474
Iacarrino, J, Steiling K, Wiener RS. “Lung Cancer Screening In A Safety-Net Hospital: Implications Of Screening A Real-World Population Versus The National Lung Screening Trial.” Ann Am Thorac Soc, 2018; 15(12):1493-1495. PMID: 30199643
Munoz-Largacha JA*, Steiling K*, Kathuria H, Charlot M, Fitzgerald C, Suzuki K, Litle VR. “Initial Surgical Experience Following Implementation of Lung Cancer Screening at an Urban Safety Net Hospital.” Journal of Thoracic and Cardiovascular Surgery, 2018; 155(6):2674-2681. *co-first authors PMID: 29534906
Grayson PC, Steiling K, Platt M, Berman J, Zhang X, Xiao J, Alekseyev YO, Liu G, Monach P, Kaplan MJ, Spira A, Merkel PA. “Defining the nasal transcriptome in granulomatosis with polyangiitis.” Arthritis and Rheumatology, 2015; 67(8):2233-9. PMCID: PMC4519398
Christenson SA, Steiling K, van den Berge M, Hijazi K, Hiemstra PS, Postma DS, Lenburg ME, Spira A, Woodruff PG. “Asthma-COPD overlap: clinical relevance of genomic signatures of Type 2 inflammation in COPD.” Am J Respir Crit Care Med, 2015; 191(7):758-766. PMCID: PMC4407484
van den Berge M, Steiling K, Timens W, Hiemstra PS, Sterk PJ, Heijink IH, Liu G, Alekseyev Y, Lenburg ME, Spira A*, Postma DS*. “Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biologic pathways associated with disease activity.” Thorax, 2014;69(1):14-23. PMCID:PMC388587. *contributed equally
Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev Y, Sin D, Pare P, Hogg JC, McWilliams A, Hiemstra PS, Sterk PJ, Timens W, Chang JT, Sebastiani P, O’Connor G, Bild AH, Postma DS, Lam S, Spira A*, Lenburg ME*. “A dynamic bronchial airway gene expression signature of COPD and lung function impairment.” Am J Resp Crit Care Med, 2013; 187(9):933-42. PMCID:3707363.
Brody JS, Steiling K. “Interaction of cigarette exposure and airway epithelial cell gene expression.” Annu Rev Physiol, 2011; 73:437-456. PMID: 21090967
Steiling K, Kadar AY, Bergerat A, Flanigon J, Sridhar S, Shah V, Lenburg ME, Brody JS, Steffen M, Spira A. “Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers” PLoS ONE, 2009;4(4):e5043.
Spira A, Beane JE, Shah V, Steiling K, Liu G, Schembri F, Gilman S, Dumas YM, Calner P, Sebastiani P, Sridhar S, Beamis J, Lamb C, Anderson T, Gerry N, Keane J, Lenburg ME, Brody JS. “Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer.” Nature Medicine, 2007; 13: 361-366. PMID: 1733437
Complete List of Published Work in MyBibliography: https://www.ncbi.nlm.nih.gov/myncbi/1tCuqnz60A2AR/bibliography/public/