Andrew A. Wilson, M.D.

Faculty and Fellows

Assistant Professor of Medicine

BU Profile for Dr. Wilson

Medical School: University of Texas Southwestern Medical School
Internship: University of Texas Southwestern Medical School
Residency: University of Texas Southwestern Medical School
Fellowship: Boston University School of Medicine

Special Interests


  • Alpha-1 antitrypsin deficiency
  • gene therapy
  • alveolar macrophage biology
  • embryonic stem cells


  • Critical Care Medicine
  • Tuberculosis

My laboratory research to date has focused on using lentiviruses to develop a gene therapy for alpha-1 antitrypsin deficiency. I have approached this problem through the manipulation of two target cell populations: hematopoietic stem cells and alveolar macrophages. Both approaches have resulted in long-term expression of human alpha-1 antitrypsin in laboratory animals. In addition to the in-vivo overexpression of alpha-1 antitrypsin, I am interested in manipulating other genes which may play a role in the pathogenesis of COPD, such as NF-kB.

A second area of interest is embryonic stem cell biology. I am working with Darrell Kotton and others in our division to study the progression of definitive endoderm to lung epithelium.

Selected Publications:

Please see BU Profile for complete Publications list