Andrew A. Wilson, M.D.
Faculty and Fellows
Assistant Professor of Medicine
Medical School: University of Texas Southwestern Medical School
Internship: University of Texas Southwestern Medical School
Residency: University of Texas Southwestern Medical School
Fellowship: Boston University School of Medicine
- Alpha-1 antitrypsin deficiency
- gene therapy
- alveolar macrophage biology
- embryonic stem cells
- Critical Care Medicine
My laboratory research to date has focused on using lentiviruses to develop a gene therapy for alpha-1 antitrypsin deficiency. I have approached this problem through the manipulation of two target cell populations: hematopoietic stem cells and alveolar macrophages. Both approaches have resulted in long-term expression of human alpha-1 antitrypsin in laboratory animals. In addition to the in-vivo overexpression of alpha-1 antitrypsin, I am interested in manipulating other genes which may play a role in the pathogenesis of COPD, such as NF-kB.
A second area of interest is embryonic stem cell biology. I am working with Darrell Kotton and others in our division to study the progression of definitive endoderm to lung epithelium.
Please see BU Profile for complete Publications list