Martin Joyce-Brady, M.D.

Faculty and Fellows


Associate Professor of Medicine
Director, Pulmonary, Respiratory Therapy and Ventilator Care Services
Radius Specialty Hospital-Boston/Quincy

Medical School: University of Maryland School of Medicine
Internship: Boston City Hospital
Residency: Boston City Hospital
Chief Residency: Boston City Hospital
Fellowship: The Pulmonary Center at Boston University

Board Certifications:

  • Internal Medicine
  • Pulmonary Medicine
  • Critical Care Medicine

Special Interests:

Research:

  • Lung Development
  • Regulation of Perinatal Lung Gene Expression
  • Role of lung and lung lining fluid glutathione metabolism in antioxidant defense

Clinical:

  • Outcomes of Patients requiring Long Term Mechanical Ventilation
  • Ventilator associated pneumonia in the Long Term Acute Care Hospital setting
  • Critical Care Medicine

Dr. Joyce-Brady is Associate Professor in the Department of Medicine. He is an Attending Physician for the Medical Intensive Care Unit and the Pulmonary Consultation Service at Boston Medical Center . He is also the Director of Pulmonary, Respiratory Therapy and Ventilator Care Services at The Radius Specialty Hospital-Boston and Quincy.

Dr. Joyce-Brady’s research is focused on the response of the developing and the adult lung to oxidant stress. His focus is on glutathione and glutathione metabolism, particularly in the lung lining fluid that baths the surface of the lung. His laboratory has characterized the key enzyme in glutathione metabolism, gamma-glutamyl transferase (GGT), and a mouse model of GGT deficiency, the GGTenu1 mouse. This work has revealed the presence of glutathione metabolism in LLF and a novel target that can augment lung lining fluid glutathione content under oxidant stress associated with inflammatory lung disease.

His laboratory has also utilized several tools to study gene expression in the developing lung, including suppression subtractive hybridization, differential display and microarrays. Selected genes that are developmentally regulated in the perintal period are now under study in adult lung to decipher their role in repair following injury. One such gene, fibulin-5, is a regulator of elastogenesis and severe emphysema develops with fibulin-5 deficiency in the knock out lung. Fibulin-5 is a matrix protein that also functions in antioxidant defense and current studies are aimed at integrating the loss of elastogenesis with oxidant stress.

For more details see the web page for Dr. JC Jean

His clinical interests center on the outcomes of patients requiring long term mechanical ventilatory support in the environment of the long term acute care hospital (LTACH). He has defined a tool to predict weaning success and the epidemiology of ventilator-associated pneumonia (VAP) in his LTACH, Radius Specialty Hospital. The overall goal is to increase translational research to improve outcomes in this ever expanding population of LTACH patients.

Selected Publications:

  1. M Joyce-Brady, JC Jean, RE Marc, LA Brown. Lung Lining Fluid Glutathione in Antioxidant Defense and Cysteine Supply. In: Research Advances in Respiratory Cell & Molecular Biology. (Ed. RH Mohan, Kerala, India), 2009; 1: 1-18.
  2. Walkey AJ, Reardon CC, Sulis CA, Nace RN, Joyce-Brady M. Epidemiology of Ventilator-Associated Pneumonia in a Long Term Acute Care Hospital. Infection Control Hospital Epidemiology. 2009; 30:319-24.
    3.MH Lowry, BP McAllister, LAS Brown, S Amar, WW Cruickshank, JC Jean, and M Joyce-Brady. Lung Lining Fluid Glutathione Attenuates IL-13- Induced Asthma. American Journal of Respiratory Cell and Molecular Biology 38:509-516, 2008 .
  3. ES Klings, MH Lowry, G Li, JC Jean, M Feelisch and M Joyce-Brady. Hyperoxia Alters Nitric Oxide Metabolism and Increases Lung Cell Injury in the Gamma-Glutamyl Transferase Deficient GGTenu1 Mouse. American Journal of Pathology (revision requested).
  4. JC Jean, J Lu. M Joyce-Brady, WV Cardoso. Regulation of Fgf10 Gene Expression in Murine Mesenchymal Cells. Journal of Cellular Biochemistry 103:1886-1894, 2008.
  5. JC Jean, C Rich and M Joyce-Brady. Hypoxia induces brain-specific Aldolase C by a HIF-1 dependent mechanism in lung epithelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology. 291: L950-956. 2006.
  6. PP Kuang, M Joyce-Brady, XH Zhang, JC Jean and Ronald H. Goldstein. Fibulin-5 Gene Expression in Human Lung Fibroblasts Is Regulated by TGF-ß and Phosphatidylinositol 3-kinase activity. American Journal of Physiology : Cell Physiology. 291 (6): C1412-1421. 2006.
  7. AS Spira, E George, G Liu, Y Liu, JS Brody, JC Jean and M Joyce-Brady. Developmental Regulation of Klf4 in the Perinatal Lung. (Manuscript in preparation).
  8. PP Kuang, RH Goldstein, Y Liu , DC Rishikof, JC Jean, M Joyce-Brady. 2003. Coordinate Expression of Fibulin-5/DANCE and elastin during lung injury repair. Am J Cell Mol Phys Lung Cell Molec Biol. 285 (5): L1147-52.
  9. JC Jean, Y Liu, RE Marc and M Joyce-Brady. 2003. The Importance of Gamma-Glutamyl Transferase in Lung Glutathione Homeostasis and Antioxidant Defense. Biofactors. 17: 161-173.
  10. JC Jean, Y Liu , LA Brown, RE Marc, ES Klings and M Joyce-Brady. 2002. The GGT Deficient Mouse Lung is under Oxidant stress in Normoxia. American Journal of Physiology Lung Cellular and Molecular Physiology. 283(4): L766-776.
  11. JC Jean, I. Eruchalu, Ciao, YX. and M. Joyce-Brady. 2002. DANCE In Developing and Injured Lung. American Journal of Physiology Lung Cellular and Molecular Physiology 282: L75-L82
  12. Joyce-Brady M, JC Jean and RP Hughey. 2001. Gamma-Glutamyl Transferase and Its Isoform Mediate an Endoplasmic Reticulum Stress Response. Journal of Biological Chemistry. 276: 9468-9477
  13. JC Jean, Cary O. Harding, Sean M. Oakes, Qiang Yu and Martin Joyce-Brady. 1999. γ-glutamyl transferase Deficiency in the GGTenu1 Mouse results from a single point mutation that leads to a stop codon in the first coding exon of GGT mRNA. Mutagenesis.14: 31-36
  14. Takahashi, Y, SM Oakes, T Miura and M Joyce-Brady. 1997. Induction of the gamma-glutamyl transferase gene in bronchiolar-alveolar regions of Rat Lung following exposure to Nitrogen Dioxide. Toxicology and Applied Pharmacology 143: 388-396.
  15. SM Oakes, Y Takahashi, MC Williams and M. Joyce-Brady. 1997. Ontogeny of γ-glutamyl transferase in rat lung. Amer. J. Physiology 272 (Lung Cellular and Molecular Physiology 16): L739-L744.
  16. M Joyce-Brady, SM Oakes, D Wuthrich and Y Laperche. 1995. Three Alternative Promoters of the Rat Gamma?-Glutamyl Transferase Gene Are Active in Developing Lung and Are Differentially Regulated by Oxygen after Birth. Journal of Clinical Investigation 97:1774-1779.
  17. Joyce-Brady M, Y Takahashi, SM Oakes, AK Rishi, RA Levine, CL Kinlough and RP Hughey. 1994. Synthesis and Release of Amphipathic gamma?-glutamyl transferase by the Pulmonary Alveolar Type 2 Cell: Its Distribution throughout the Gas Exchange Portion of the Lung Indicates a New Role for Surfactant. Journal of Biological Chemistry 269:14219-14226.

Selected Reprints:

  1. Lung Lining Fluid Glutathione Attenuates IL13-Induced Asthma
  2. The importance of gamma-glutamyl transferase in lung glutathione homeostasis and antioxidant defense
  3. Coordinate expression of fibulin-5/DANCE and elastin during lung injury repair
  4. Gamma-Glutamyltransferase and Its Isoform Mediate an Endoplasmic Reticulum Stress Response
  5. Hypoxia results in an HIF-1-dependent induction of brain-specific aldolase C
  6. Fibulin-5 gene expression in human lung fibroblasts is regulated by TGF
  7. Epidemiology of Ventilator-associated pneumonia in a Long-term acute care hospital

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