Katrina Steiling, MD, MSc

Faculty and Fellows


Assistant Professor of Medicine

Medical School: Boston University School of Medicine
Internship: Boston University Medical Center
Residency: Boston University Medical Center
Fellowship: Boston University Medical Center
Master’s/PhD programs: Masters of Science in Bioinformatics, College of Engineering, Boston University

Board Certifications:

  • Internal Medicine
  • Pulmonary Medicine
  • Critical Care Medicine

Special Interests:

Research:

  • Airway gene expression
  • Bioinformatics
  • Chronic Obstructive Pulmonary Disease (COPD)
  • Lung Cancer

Clinical:

  • Thoracic Oncology
  • Pulmonary Medicine
  • Critical Care Medicine

Dr. Steiling is an Assistant Professor of Medicine. She sees patients in the multidisciplinary Thoracic Oncology Clinic and attends in the Medical Intensive Care Unit at Boston Medical Center.

Dr. Steiling’s research focuses on applying high-throughput genomic tools and emerging computational methods to develop improved diagnostics, prognostics, and risk stratification tools for phenotypically complex lung diseases such as COPD and lung cancer. Dr. Steiling’s primary research involves gene expression profiling of the airway epithelium from individuals with COPD in order to understand the molecular mechanisms of this disease and its relationship to lung cancer. She has also worked to apply airway gene expression profiling to the diagnosis of lung cancer, to understand the relationship between smoking-induced changes in gene expression in the bronchial airway and the upper airway, and to elucidate the relationship between smoking-induced changes in airway gene and protein expression.

Selected Publications:

  • Gower AC, Steiling K, Brothers JF, Lenburg ME, Spira A. “Transcriptomic
    studies of the airway ‘field of injury’ associated with smoking-related lung
    disease.” Proc Am Thorac Soc, 2011; 8(2):173-179.
  • Brody JS, Steiling K. “Interaction of cigarette exposure and airway epithelial
    cell gene expression” Annu Rev Physiol. 2011; 73:437-456.
  • Spira A, Steiling K. Topics in genetics and genomics: Gene Expression.
    In: UpToDate, Basow DS (Ed), UpToDate, Waltham, MA, 2010.
  • Steiling K, Lenberg ME, Spira A. “Airway Gene Expression in Chronic Obstructive Pulmonary Disease.” Proc Am Thorac Soc. 2009;6:697-700.
  • Steiling K, Kadar AY, Bergerate A, Flanigon J, Sridhar S, Shah V, Ahmad QR, Brody JS, Lenburg ME, Steffen M, Spira A. “Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers.” PLoS ONE. 2009;4(4):e5043.
  • Steiling K, Ryan J, Brody JS*, Spira A*. “The field of tissue injury in the lung and airway.” Cancer Prevention Research, 2008; 1(6):396-403. *contributed equally as senior author
  • Schembri F*, Sridhar S*, Zeskind J, Shah V, Gustafson A, Steiling K, Liu G, Dumas YM, Zhang X, Brody JS, Lenburg ME, Spira A. “Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium.” BMC Genomics, 2008; 9:259. * contributed equally
  • Beane J, Sebastiani P, Whitfield TH, Steiling K, Dumas YM, Lenburg ME, Spira A. “A prediction model for lung cancer diagnosis that integrates genomic and clinical features.” Cancer Prevention Research, 2008; 1:56-64.
  • Spira A, Beane JE, Shah V, Steiling K, Liu G, Schembri F, Gilman S, Dumas YM, Calner P, Sebastiani P, Sridhar S, Beamis J, Lamb C, Anderson T, Gerry N, Keane J, Lenburg ME, Brody JS. “Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer.” Nature Medicine, 2007; 13(3):361-6.
  • van den Berge M, Steiling K, Timens W, Hiemstra PS, Sterk PJ, Heijink IH, Liu G, Alekseyev YO, Lenburg ME, Spira A*, Postma DS*. “Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity.” Thorax, 2013. [Epub ahead of print]
  • Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, Sin D, Pare P, Hogg JC, McWilliams A, Hiemstra PS, Sterk PJ, Timens W, Chang JT, Sebastiani P, O’Connor GT, Bild AH, Postma DS, Lam S, Spira A*, Lenburg ME*. “A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment.” Am J Respir Crit Care Med, 2013; 187(9):933-942.

Links:

Clinic Sites:

Dr. Steiling sees patients in the Thoracic Oncology Center at Boston Medical Center.