Daniel J. Gottlieb, M.D., MPH

Faculty and Fellows


Associate Professor of Medicine
Associate Program Director of GCRC (General Clinical Research Center)
Director, Sleep Disorders Center, VA Boston Healthcare System

Medical School: University of Pennsylvania
Internship: University of Minnesota
Residency: University of Minnesota
Chief Residency: Minneapolis VA Medical Center
Fellowship: Boston University
Master’s program: Boston University School of Public Health MPH

Board Certifications:

  • Internal Medicine
  • Pulmonary Medicine
  • Sleep Medicine

Special Interests:

Research:

  • Epidemiology of obstructive sleep apnea/hypopnea
  • Cardiovascular consequences of obstructive sleep apnea/hypopnea
  • Neurocognitive consequences of obstructive sleep apnea/hypopnea
  • Metabolic consequences of sleep deprivation
  • Genetics of sleep and sleep disorders

Clinical:

  • Sleep Medicine

Clinical activities are based at the VA Boston Healthcare System, where Dr. Gottlieb is a member of the Pulmonary and Critical Care Division of the Medical Service and Director of the Sleep Disorders Center. Research activities currently focus on the epidemiology of obstructive sleep apnea/hypopnea and sleep deprivation in various observational cohort studies. These include the Sleep Heart Health Study, a multi-center NHLBI-funded study of the cardiovascular consequences of sleep apnea, of which Dr. Gottlieb is a member of the Polysomnography Committee and co-PI of the Framingham Heart Study site, where he has overseen the polysomnographic data collection procedures. Dr. Gottlieb was PI of a recently completed NHLBI-funded study of the neurobehavioral consequences of sleep apnea in children, the results of which have been published in part, with additional manuscripts under review. Data from both of these studies are being evaluated in a study of ECG estimators of sleep physiology, of which Dr. Gottlieb is a co-investigator. He is also PI of the Boston field center of the NHLBI-funded clinical trial entitled “Apnea Positive Pressure Long-term Efficacy Study,” a co-investigator in a study of the relation between alcohol’s effects on sleep and subsequent performance impairment, and a co-investigator in a study of an interactive voice-response system for improving CPAP adherence. He serves on the American Academy of Sleep Medicine Poprtable Monitoring Task Force, developing guidelines for home monitoring for sleep apnea.

Selected Publications:

  1. Gottlieb DJ, Redline S, Nieto FJ, Baldwin CM, Newman AB, Resnick HE, Punjabi NM. Association of usual sleep duration with hypertension: The Sleep Heart Health Study. Sleep 2006; (in press).
  2. Patwardhan AA, Larson MG, Levy D, Benjamin EJ, Leip EP, Keyes MJ, Wang TJ, Gottlieb DJ, Vasan RS. Obstructive sleep apnea and plasma natriuretic peptide levels in a community-based sample. Sleep 2006 (in press).
  3. Patel SR, Malhotra A, Gottlieb DJ, White DP, Hu FB. Association between reduced sleep and weight gain in women. Am J Epidemiol 2006 (in press).
  4. Gottlieb DJ. Can sleep apnea be treated without modifying anatomy? [editorial]. N. Engl. J. Med. 2005 (in press).
  5. Gottlieb DJ, Punjabi NM, Newman AB, Resnick HE, Redline S, Baldwin CM, Nieto FJ. Association of Sleep Time with Diabetes Mellitus and Impaired Glucose Tolerance. Arch Intern Med; 2005; 165:863-868.
  6. Gottlieb DJ. The future risks of childhood sleep-disordered breathing [editorial]. Sleep 2005; 28:796-797.
  7. Gottlieb DJ, Chase C, Vezina RM, Heeren TC, Corwin MJ, Auerbach SH, Weese-Mayer DE, Lesko SM. Sleep-Disordered Breathing: Association with Poorer Cognitive Function in 5-Year-Old Children. J Pediatr; 2004; 145:458-464.
  8. Gottlieb DJ, DeStefano AL, Foley DJ, Mignot E, Redline S, Givelber RJ, Young TB. APOE ?4 is associated with obstructive sleep apnea/hypopnea: The Sleep Heart Health Study. Neurology 2004; 63:664–668
  9. Punjabi NM, Shahar E, Redline S, Gottlieb DJ, Givelber R, Resnick HE. Sleep-Disordered Breathing, Glucose Intolerance, and Insulin Resistance: The Sleep Heart Health Study. Am. J. Epidemiol. 2004; 160:521–530.
  10. DeMolles DA, Sparrow D, Gottlieb DJ, Friedman R. A Telecommunications System in Sleep Apnea Management. Medical Care. 2004; 42:764-769.
  11. Wilk JB, DeStefano AL, Myers RH, Cupples LA, Joost O, Slater K, Atwood LD, Heard-Costa NL, Herbert A, O’Connor GT, Gottlieb DJ. Linkage and Association with Quantitative Pulmonary Function Measures on Chromosome 6q27 in the Framingham Heart Study. Hum. Molec. Gen. 2003; 12:2745-2751.
  12. Gottlieb DJ, Vezina RM, Chase C, Lesko SM, Heeren TC, Weese-Mayer DE, Auerbach SH, Corwin MJ. Sleep-Disordered Breathing in Five-Year-Old Children is Associated with Sleepiness and Problem Behaviors. Pediatrics 2003; 112:870-877.
  13. Wilk JB, DeStefano AL, Arnett DK, Rich SS, Djousse L, Crapo RO, Leppert MF, Province MA, Cupples LA, Gottlieb DJ, Myers RH. A Genomewide Scan of Pulmonary Function Measures in the NHLBI Family Heart Study. Am. J. Resp. Crit. Care Med. 2003; 167:1528-1533.
  14. Walter RE, Beiser A, Givelber RJ, O’Connor GT, Gottlieb DJ. Association between glycemic state and lung function: The Framingham Heart Study. Am. J. Resp. Crit. Care Med. 2003; 167:911-916.

Selected reprints:

  1. APOE ?4 is associated with obstructive sleep apnea/hypopnea: The Sleep Heart Health Study.
  2. Association of Sleep Time with Diabetes Mellitus and Impaired Glucose Tolerance.
  3. Sleep-Disordered Breathing: Association with Poorer Cognitive Function in 5-Year-Old Children.

Links:

Dr Gottlieb sees clinic patients at the Boston Veterans Administration Healthcare System (West Roxbury campus). Call 617-323-7700 ext 6427 for an appointment.