Andrew A. Wilson, M.D.
Faculty and Fellows
Assistant Professor of Medicine
Medical School: University of Texas Southwestern Medical School
Internship: University of Texas Southwestern Medical School
Residency: University of Texas Southwestern Medical School
Fellowship: Boston University School of Medicine
- Alpha-1 antitrypsin deficiency
- gene therapy
- alveolar macrophage biology
- embryonic stem cells
- Critical Care Medicine
My laboratory research to date has focused on using lentiviruses to develop a gene therapy for alpha-1 antitrypsin deficiency. I have approached this problem through the manipulation of two target cell populations: hematopoietic stem cells and alveolar macrophages. Both approaches have resulted in long-term expression of human alpha-1 antitrypsin in laboratory animals. In addition to the in-vivo overexpression of alpha-1 antitrypsin, I am interested in manipulating other genes which may play a role in the pathogenesis of COPD, such as NF-kB.
A second area of interest is embryonic stem cell biology. I am working with Darrell Kotton and others in our division to study the progression of definitive endoderm to lung epithelium.
- Wilson AA, Murphy GJ, Hamakawa H, Kwok LW, Srinivasan S, Hovav AH, Mulligan RC, Amar S, Suki B, and Kotton DN. “Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages.” J Clin Invest. 2010 Jan 4;120(1):379-89.
- Wilson AA and Kotton DN: “Another notch in stem cell biology: Drosophila intestinal stem cells and the specification of cell fates.” Bioessays, 30:197, 2008.
- Wilson AA, Kwok LW, Hovav AH, Ohle FJ, Little FF, Fine A, and Kotton DN: “Sustained Expression of α 1-antitrypsin After Transplantation of Manipulated Hematopoietic Stem Cells.” Am J Respir Cell Mol Biol. 39:133, 2008.