Darrell N. Kotton, M.D.

Associate Professor of Medicine and Pathology

Director, Center for Regenerative Medicine (CReM)

Medical School: Washington University School of Medicine
Internship: University of Pennsylvania
Residency: University of Pennsylvania
Fellowship: Boston University
Post-Doctoral Research Fellowship: Harvard Medical School
Board Certifications: Internal Medicine, Pulmonary Medicine, Critical Care Medicine

Special Interests:

RESEARCH:

CLINICAL:

Dr. Kotton is Associate Professor in the Department of Medicine and in the Department of Pathology and Laboratory Medicine. He attends in the Medical Intensive Care Unit and on the Pulmonary Consultation Service at Boston Medical Center.

Dr. Kotton’s research focuses on stem cell biology and gene therapy related to lung injury and repair. He is an NIH-funded Principal Investigator and a member of several research groups at the Pulmonary Center: the Stem Cell Biology and Gene Therapy Group, the Epithelial Group, and the Developmental Biology Group. Dr. Kotton’s laboratory currently utilizes several stem cell populations, including embryonic stem cells in order to develop novel stem cell-based therapies for lung disease. In addition, Dr. Kotton specializes in the genetic manipulation of stem cells as well as resident lung cells using lentiviral vectors. Projects in his lab are currently focused on utilizing these novel vectors for the study of alpha-1 anti-trypsin deficiency, COPD, Cystic Fibrosis, and lung inflammatory pathways.

In 2009 Dr Kotton and Dr. Gustavo Mostoslavsky became Co-Directors of a campus-wide research initiative, the Boston University Center for Regenerative Medicine (CReM), bringing together several research groups on campus focused on various aspects of stem cell biology and regenerative medicine. For more information, please visit the CReM website.

For more detailed information on Dr. Kotton’s research, see the Kotton Lab website.

Selected Publications:

  1. Wilson AA, Murphy GJ, Hamakawa H., Kwok LW, Srinivasan S, Hovav AH, Mulligan RC, Amar S, Suki B, and Kotton DN.” Amelioration of emphysema in mice via lentiviral transduction of long-lived pulmonary alveolar macrophages”. Journal of Clinical Investigation. (in press).

  2. Greenhill SR, Kotton DN. Pulmonary alveolar proteinosis: a bench-to-bedside story of granulocyte-macrophage colony-stimulating factor dysfunction. Chest. 2009 Aug;136(2):571-7
  3. Sommer CA, Stadtfeld M, Murphy GJ, Hochedlinger K, Kotton DN, Mostoslavsky G. “Induced pluripotent stem cell generation using a single lentiviral stem cell cassette.“ Stem Cells. 2009 Mar;27(3):543-9.
  4. Cardoso, W.V. and Kotton, DN, “Specification and patterning of the respiratory system”, StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.10.1, http://www.stembook.org. July 2008
  5. Sommer CA, Stadtfeld M, Murphy GJ, Hochedlinger K, Kotton DN, Mostoslavsky G. “iPS Cell Generation Using a Single Lentiviral Stem Cell Cassette.” Stem Cells. Dec 18, 2008
  6. Wilson AA, Kwok LW, Hovav AH, Ohle SJ, Little FF, Fine A, Kotton DN, “Sustained Expression of a1-antitrypsin After Transplantation of Manipulated Hematopoietic Stem Cells”. Am J Respir Cell Mol Biol. 39(2):133-41. Aug 2008
  7. Murphy GJ, Mostoslavsky G, Kotton DN, and Mulligan RC. “Exogenous Control of Mammalian Gene Expression via Modification of Translational Termination.” Nature Medicine 12(9):1093-9. Sept 2006.
  8. Kotton DN, Fabian AJ, Mulligan RC. “Failure of Bone Marrow to Reconstitute Lung Epithelium.” Am J Respir Cell Mol Biol. 33:328-334. Oct 2005.
  9. Kotton DN, Fabian AJ, Mulligan RC. “A novel stem cell population in adult liver with potent hematopoietic reconstitution activity.” Blood. 106:1574-1580. Sept 2005.
  10. Mostoslavsky G, Kotton DN, Fabian AJ, Grey JT, Mulligan RC. “Efficiency of transduction of highly purified hematopoietic stem cells by lentiviral and retroviral vectors under conditions of minimal in vitro manipulation.” Molecular Therapy 11(6):932-40. June 2005.
  11. Summer R, Kotton DN, Liang S, Fitzsimmons K, Sun X, Fine A. “Embryonic lung side population cells are hematopoietic and vascular precursors”. Am J Respir Cell Mol Biol. 33:32-40. July 2005.
  12. Kotton DN, Summer R, and Fine A. “Lung stem cells: New paradigms.” Exp Hematol. 32(4): 340. Apr 2004.
  13. Summer R, Kotton DN, Sun X, Fitzsimmons K, and Fine A. “The Origin and Phenotype of Lung Side Population Cells.” Am J Physiol Lung Cell Mol Physiol. Mar 2004.
  14. Summer R, Kotton DN, Sun X, Ma B, Fitzsimmons K, Fine A. “Side population cells and Bcrp1 expression in lung.” Am J Physiol Lung Cell Mol Physiol. 285(1):L97-104. July 2003.
  15. Kotton DN, Summer RS, Sun X, Ma BY, Fine A. “Stem cell antigen-1 expression in the pulmonary vascular endothelium.” Am J Physiol Lung Cell Mol Physiol. 284(6):L990-6. June 2003.
  16. Kotton D and Fine A. “Derivation of lung epithelium from bone marrow cells.” Cytotherapy. 5(2):169-73.. May 2003.
  17. Kotton DN, Ma BY, Cardoso, WV, Sanderson EA, Summer, RS, Williams MC, and Fine A. “Bone Marrow-Derived Cells as Progenitors of Lung Alveolar Epithelium.” Development 128: 5181-5188. December 2001.

Selected Reprints:

  1. Exogenous Control of Mammalian Gene Expression via Modification of Translational Termination
  2. Failure of Bone Marrow to Reconstitute Lung Epithelium
  3. Anovel stem-cell population in adult liver with potent hematopoietic-reconstitution activity
  4. Efficiency of Transduction of Highly Purified Murine Hematopoietic Stem Cells by Lentiviral and Oncoretroviral Vectors Under Conditions of Minimal in Vitro Manipulation
  5. Lung stem cells: New paradigms
  6. Stem cell antigen-1 expression in the pulmonary vascular endothelium
  7. Bone marrow-derived cells as progenitors of lung alveolar epithelium

Links:
Kotton lab

Center for Regenerative Medicine

Go Back to Faculty Listing

Primary teaching affiliate
of BU School of Medicine