Andrew A. Wilson, M.D.
Faculty and Fellows
Andrew A. Wilson, MD
Assistant Professor of Medicine
| Medical School: University of Texas Southwestern Medical School Internship: University of Texas Southwestern Medical School Residency: University of Texas Southwestern Medical School Fellowship: Boston University School of Medicine Board Certifications: Internal Medicine, Pulmonary Medicine, Critical Care MedicineSpecial Interests: RESEARCH:
CLINICAL:
My laboratory research to date has focused on using lentiviruses to develop a gene therapy for alpha-1 antitrypsin deficiency. I have approached this problem through the manipulation of two target cell populations: hematopoietic stem cells and alveolar macrophages. Both approaches have resulted in long-term expression of human alpha-1 antitrypsin in laboratory animals. In addition to the in-vivo overexpression of alpha-1 antitrypsin, I am interested in manipulating other genes which may play a role in the pathogenesis of COPD, such as NF-kB. A second area of interest is embryonic stem cell biology. I am working with Darrell Kotton and others in our division to study the progression of definitive endoderm to lung epithelium. Selected Publications: Wilson AA and Kotton DN: “Another notch in stem cell biology: Drosophila intestinal stem cells and the specification of cell fates.” Bioessays, 30:197, 2008. Wilson AA, Kwok LW, Hovav AH, Ohle FJ, Little FF, Fine A, and Kotton DN: “Sustained Expression of α 1-antitrypsin After Transplantation of Manipulated Hematopoietic Stem Cells.” Am J Respir Cell Mol Biol. 39:133, 2008. Links: |
