Chronic Non-Communicable Inflammatory Disorders

  The focus of this group of investigators is in understanding basic chronic inflammatory processes that contribute to a broad range of chronic inflammatory disorders. In most cases the inflammatory response is resolved by the release of endogenous anti-inflammatory mediators and inflammatory cells are eventually cleared in what is described as acute inflammation.  However the continuous accumulation and activation of leukocytes are a hallmark of chronic inflammation.  Chronic inflammation culminates in devastating events, results in significant host pathology, and is associated with a number of human diseases including asthma, atherosclerosis, autoimmunity, diabetes, inflammatory bowel diseases, and periodontal diseases. This group of investigators utilizes mouse specific models of inflammatory disorders employing both genetic knockout mice and transgenic mouse models together with targeted molecular imaging to study inflammatory processes in vivo.